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Lecture 4c

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Lecture 4c 31 January 2011 Nutraceuticals and functional foods Group activity Nutraceuticals Type I -manage -lipids-triglycerides -diabetic ... – PowerPoint PPT presentation

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Title: Lecture 4c


1
Lecture 4c 31 January 2011   Nutraceuticals
and functional foods    
2
Group activity   Nutraceuticals   Type I
-manage -lipids-triglycerides   -diabetic
neuropathy/nerve conduction
velocity- evening primrose oil   -fasting
glucose down with fish oil
3
Type II- manage metabolic syndrome   -obesity
-lipids- elevated free fatty acids,
triglycerides, cholesterol and
LDL-cholesterol and small dense LDL,
decreased HDLc, oxidation issues
-blood pressure-elevated -platelet
aggregation-elevated   -insulin
sensitivity-down
4

5
OVERALL HYPOTHESIS GLA (DIETARY OIL) DGLA
PLATELET INCREASED DGLA PL - INCREASED
PGE1 PGE1 IS (ANTI-AGGREGATORY,
VASODILATORY) DECREASED AA-PL - TxA2
AND PGE2 (DECREASED) TxA2 IS
(PRO-AGGREGATORY, VASOCONSTRICTORY)
-PGE2 IS (PRO-AGGREGATORY,
VASOCONSTRICTORY)
6
Fish oil-triglycerides, fasting glucose, and
glycosylated haemoglobin down, insulin receptor
fluidity increases, platelets activity
decreases   Canola oil-improves insulin
sensitivity   Flax oil-lower dose (30 mg ALA/kg
bw/d) -higher doses (178 mg
ALA/kg bw/d) -no success
7
Evening Primrose oil-no reports in diabetics
found   Borage oil-no reports in diabetics
found   Blackcurrant oil-no reports in diabetics
found
8
Prebiotics-inulin a complex carbohydrate may
lower triglycerides and does lower
LDL and total cholesterol   -pro
posed to increase insulin sensitivity   -bot
h the lipid and the insulin sensitivity issues
still need to be rigorously tested in human
type II diabetics
9
  • vitamin supplements- appears to be no need for
    these but this is being studied
  • chromium supplement increase insulin sensitivity
    but people are not normally chromium deficient
  • magnesium- deficiency associated with type II
    diabetes-
  • -supplement improves insulin
    sensitivity

10
Central issues of functional foods versus
nutraceuticals   Concentration Purity-what
is doing what Conflicting agents ?
11
Type I diabetes Fish protein- lowers
albuminuria   Cows milk-concept of reverse
functional foods   nitrosamines-concept of
reverse functional foods   Soy
proteins-potential attack on beta cells- concept
of reverse functional foods
12
Type II diabetes-     Fish-lowers lipid
oxidation-potential yet to be tested   Tomatoes-l
ycopene- antioxidant-potential yet to be
tested   Green tea-flavonoids (eg
catechins)-antioxidant potential- potential yet
to be tested
13
Soy-flavonoids- anti-oxidant- potential yet to
be tested   -hulls-improved glucose
tolerance   Garlic-allicin- lowers cholesterol
and LDL cholesterol-potential yet to be tested

14
Probiotics-chicory seed contains inulin and
oligofructose-proposed to increase insulin
sensitivity and improve lipid profiles (decreased
triglycerides and LDL and cholesterol)
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