Keith Johnston Research Group Nanotechnology/Colloid Science [e-mail] CPE 5.414 512-471-4617

1
Keith Johnston Research GroupNanotechnology/Collo
id Sciencekpj_at_che.utexas.edu CPE 5.414
512-471-4617

• Biomedical and Pharmaceutical Nanotechnology
  Imaging and Therapeutics
• Magnetic/optical/therapeutic nanoparticles
  -cancer and atherosclerosis
• Protein drug delivery (oral, depot, pulmonary,
  parenteral)
• Nanotechnology for Energy Fundamentals
• and Applications
• Nanocrystal/Mesoporous composites
• Supercapacitors and batteries
• Catalysis- fuel cells, water oxidation
• Nanotechnology for Enhanced Oil Recovery and CO2
  Sequestration
• Electromagnetic imaging
• Emulsions/foams for mobility control

2
Molec. Specific Magnetic/Optical Imaging and
Therapy Carcinogenesis and Atherosclerosis
(Sokolov, Emelianov, Milner)
Portable imaging ultrasound, photoacoustic opt.
coherence tomography Emelianov, Milner
Include drug payloads Antibody, siRNA targeting

• Molecular Mechanisms
• Early Detection
• Prognosis
• Treatment
• Monitoring

Optical properties- theory
3
Novel concept build nanoclusters from
nanoparticles
30 nm end-to-end

• Small size (20 to 50 nm) challenging to
  synthesize
• permeation of cell membranes, leaky vasculature
  in cancers
• prolonged circulation in bloodstream
• modulate biological pathways including
  apoptosis
• Nanoclusters of nanoparticles
• pack intense and variable functionality (like
  viral capscids)
• optical(gold), and magnetic(iron oxide)
  imaging
• targeting agents (Abs, siRNA)
• drugs for delivery

Antibodies, siRNA
4
Monoclonal Antibodies for Cancer, Cardiovascular
and Infectious Diseases Need for Drug Delivery
http//en.wikipedia.org/wiki/ImageMonoclonalAb.jp
g
gt20 of all biopharmaceuticals in clinical trials
are mAbs

Therapeutic goal 400 mg in 1 ml sub-Q injection
instead of IV Our approach suspensions instead
of solutions- min. electroviscous effects for
particles instead of protein molecules
5
Nanoparticle-mesoporous support composites in
catalysis and energy storage (Dan Slanac, Mehul
Patel)(Supercapacitors, batteries, fuel cells,
water oxidation etc.)
Presynthesis of bimetallic catalysts control
nanocrystal size, compostion, surface atoms
Infuse into well-ordered mesoporous materials
dispersibility metal-support interactions
3-10 nm pores
6
Electrochemical supercapacitors for high power
density and energy density (high stability vs
batteries)
Adsoption of ions on surface(e.g.
Li) (MnO2)surface C e- ?
(MnO2-C)surface Surface redox reaction MnO2
C e- ? MnOOC
MnO2 nanoparticles in conformal film on
mesoporous C- high surf area, rapid diffusion
16 wt MnO2
7
Magnetic Nanoparticle Sensors for Oil reservoirs
and CO2 sequestration

• Nano size flows freely in porous media
• 
  
• Surface coating adjusts contact angle
• and adsorption at interface
• Uniform size well-structured monolayer
• at interface with unique rheology/elasticity
  
• Electromagnetic field generates acoustic

8

• Bionanoparticles Avi Murthy, Jasmine Tam
  murthy_at_che.utexas.edu 5.432
• Protein delivery Andrea Miller
  mam5228_at_che.utexas.edu 5.428
• Energy Dan Slanac dslanac_at_che.utexas.edu
  5.426, 30