Therapeutic Peptides for Cardiovascular Disease and Cancer - PowerPoint PPT Presentation

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Therapeutic Peptides for Cardiovascular Disease and Cancer

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... the-shelf products - innovative intravascular stent systems - small diameter vascular grafts - pacemakers - heart valve ... development of highly specific ... – PowerPoint PPT presentation

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Title: Therapeutic Peptides for Cardiovascular Disease and Cancer


1
Therapeutic Peptides forCardiovascular Disease
and Cancer
  • Cam Patterson, MD, MBA, FACC, FAHA
  • Ernest and Hazel Craige Distinguished Professor
  • of Cardiovascular Medicine
  • Chief, Division of Cardiology
  • Director, Carolina Cardiovascular Biology Center
  • University of North Carolina at Chapel Hill

2
Endothelial Progenitor Cells (EPC)from Biology
to Treatment
  • ? In 1997, EPC were first identified in adult
    human peripheral blood
  • ? EPC are immature cells capable of
    differentiating into mature endothelial cells
  • ? EPC can play an important role in the formation
    of new blood vessels
  • - mobilization from the bone marrow
  • - migration through the
    circulation
  • - incorporation into blood
    vessels
  • ? Clinically, the number and function of EPC have
    been positively linked with improved endothelial
    function and regeneration

Rosenzweig A., NEJM, 348, 581 (2003).
3
Phage Display Technology to Identify
PeptidesSpecific for Endothelial Progenitor Cells
4
Peptides Immobilized on a Biomaterial Scaffold to
Improve Cyto- and Blood- compatibility of Implants
Veleva A. et al., Biomaterials, 29, 3656 (2008).
5
New Functional Tools to Target Tumor Vasculature
  • ? Tumor angiogenesis has a critical role in
    promoting the growth of most carcinomas
  • ? EPC play an important role in
    angiogenesis-mediated tumor progression

? To utilize endogenous EPC as natural vectors to
deliver diagnostic and therapeutic reagents to
tumors
6
Market Potential
  • ? Regenerative Medicine
  • - cell separations
  • - production of pure cell populations for
    allogeneic stem cell therapies

? Medical Implant Technologies to treat
cardiovascular diseases, off-the-shelf
products - innovative intravascular stent
systems - small diameter vascular grafts -
pacemakers - heart valve repair - arterial
septal repair implants
? Oncology - targeting of tumor-associated
blood vessels - non-invasive detection of
small cancer tissue, primary tumors
metastases - targeted therapeutics, development
of highly specific drug delivery systems -
personalized medicine, monitoring efficacy of
therapies
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