Realizing the Promise of Regenerative Medicine: Growing Tissues and Organs for Transplantation - PowerPoint PPT Presentation

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Realizing the Promise of Regenerative Medicine: Growing Tissues and Organs for Transplantation

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Realizing the Promise of Regenerative Medicine: Growing Tissues and Organs for Transplantation Richard E. Swaja Director SC Bioengineering Alliance – PowerPoint PPT presentation

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Title: Realizing the Promise of Regenerative Medicine: Growing Tissues and Organs for Transplantation


1
Realizing the Promise of Regenerative
MedicineGrowing Tissues and Organs for
Transplantation
  • Richard E. Swaja
  • Director SC Bioengineering Alliance
  • Director Clemson-MUSC Bioengineering
  • SC COEE Endowed Chair in Regenerative Medicine
    MUSC
  • Conference on Resolving the Shortage of Organs
    for Transplantation
  • November 20, 2009

2
Regenerative Medicine Tissue Engineering
  • Definition Combining principles and methods
    from the physical and engineering sciences,
    medicine, and biology to exploit living cells for
    therapeutic and diagnostic purposes.
  • Goal - Develop innovative technologies and
    approaches that will enable repair, replacement,
    or restoration of diseased cells, tissues, and
    organs.
  • The Field Biochemistry, Biology, Biomaterials,
    Biomechanics, Computer Science, Engineering,
    Imaging, Informatics, Medicine, and Physics

3
The Promise
  • Diagnostic Grow tissues in vitro for testing
    drug metabolism, uptake, toxicity, and
    pathogenicity.
  • Therapeutic Grow tissues and organs in vivo or
    in vitro for transplantation.
  • Vision Industrial-type production of functional
    complex tissues and organs for biomedical
    applications.

4
Creating Bioartificial Complex Tissues and Organs
- Biofabrication
  • Bioprinting Basis for fabrication
  • - Computer-aided, layered deposition of
    materials (hydrogel) and living (stem) cells
  • - Different from classic solid scaffold
    followed by cell seeding in bioreactor One step
    compared to two
  • - More amenable to complex tissues and
    organs and vascularization

5
BioPrinting Using BioInk
BioInk Aggregates of stem cells hydrogel
(morphogens)
6
Stem Cells Derived from Fat Tissue
7
Induced Pluripotent (iPS) Cells
Transfect 3 genes
7
Expand to 10
ADULT HUMAN SKIN CELLS
8
Currently Available Industrial Bioprinters
9
Creating Bioartificial Complex Tissues and Organs
Vascularization
  • Engineering a branched human vascular tree
  • - The problem with creating 3D living
    tissues more than 4 cell layers thick
  • - Limits tissue engineering benefits to
    avascular structures (cartilage and cardiac
    valves)

10
The future of tissue and organ biofabrication
depends on engineering a functional vascular tree
Break 4 cell barrier
11
The South Carolina ProjectEngineering a
Vascular Tree
12
Roadmap Timeline

2003
2009
2020
13
Biofabrication Plus and Minus
  • Organs generated using patients stem cells no
    host rejection issues.
  • Organs can be tailored to patients specific
    characteristics.
  • Capable of industrial-type production.
  • Its a big endeavor and it is going to take some
    time, but it will be worth the effort.
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