Hypersensitivity (Type III) Hypersensitivity (Type IV)

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Hypersensitivity (Type III) Hypersensitivity
(Type IV)

• Huan-Yao Lei, Ph.D.
• Department of Microbiology Immunology
• College of Medicine
• National Cheng Kung University

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Summary of Chapter 25 Hypersensitivity (III)

• Diseases caused by immune complexes can be
  divided into three groups.
• Immune complexes can trigger a variety of
  inflammatory processes.
• Experimental models demonstrate the main immune
  complex diseases.
• Immune complexes are normally removed by the
  mononuclear phagocyte system.
• The size of immune complexes affects their
  deposition.
• Immune complex deposition in the tissues results
  in tissue damage.
• Deposited immune complexes can be visualized
  using immunofluorescence.

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Summary of Chapter 26 Hypersensitivity (Type IV)

• DTH reflects the presence of antigen-specific CD4
  T cells.
• Contact hypersensitivity occurs at the point of
  contact with an allergen.
• Tuberculin-type hypersensitivity is induced by
  soluble antigens from a variety of organisms.
• Granulomatous hypersensitivity is clinically the
  most important form of type IV hypersensitivity.
• Many chronic diseases manifest type IV
  granulomatous hypersensitivity.

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