Hematological Abnormalities in Systemic Diseases - PowerPoint PPT Presentation

Loading...

PPT – Hematological Abnormalities in Systemic Diseases PowerPoint presentation | free to view - id: 6fb67e-NWIyN



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

Hematological Abnormalities in Systemic Diseases

Description:

Title: Hematological Abnormalities in Systemic Diseases Author: nChamen Last modified by: fSayes Created Date: 1/16/2007 11:55:45 AM Document presentation format – PowerPoint PPT presentation

Number of Views:73
Avg rating:3.0/5.0
Slides: 23
Provided by: nCh127
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: Hematological Abnormalities in Systemic Diseases


1
Hematological Abnormalities in Systemic Diseases
  • By
  • Fatin Al-Sayes
  • MD, MSc, FRCPath
  • Consultant Hematology
  • Assistant Professor

2
Anemia in renal disease
  • Seen in chronic renal failure
  • Severity relates to the degree of renal
    impairment
  • Due to inadequate EPO secretion
  • Other contributory factors
  • Bone marrow suppression secondary to uraemia
  • ? RBCs survival
  • Uraemia cause platelets dysfunction leading to
    anaemia secondary to blood loss
  • Iron, folate loss during dialysis ? anemia
  • Aluminum toxicity

3
(No Transcript)
4
Platelet and coagulation abnormalities
  • Platelets dysfunction occur in CRF secondary to
    uraemia
  • HUS TTP are associated with thrombocytopenia
  • Nephrotic syndrome is associated with thrombosis.

5
Laboratory changes
  • Mostly normocytic-normochromic anemia.
  • Specific abnormalities in WBC, platelets

6
Anemia in liver disease
  • Common

Causes
  • Chronic disorder
  • Alcohol ? with all direct effect on
    erythropoeisis
  • Folate deficiency
  • Alcohol ? on folate metabolism
  • Nutritional deficiency
  • Blood loss from oesophageal varices
  • Hypersplenism

7
(No Transcript)
8
cont. of Causes
  • Hemolytic anemia
  • Zieves syndrome
  • Autoimmune in association with chronic active
    hepatitis
  • Viral hepatitis may provoke oxidative hemolysis
  • Acute liver failure
  • Coagulation abnormalities
  • DIC and microangiopathic hemolytic anemia

9
(No Transcript)
10
Endocrine disease
  • Hypopituitarism
  • Normocytic-normochromic anemia
  • Leucopenia
  • Thyroid disorders
  • Hypothyroidism can cause normocytic-normochromic
    anemia, microcytic or macrocytic type of anemia
  • Adrenal disorders
  • Hypoadrenalism result in normochromic, normocytic
    anemia
  • Cushings disease result in erythrocytosis

11
Connective tissue disordersHematological changes
  • Anemia of chronic disorders
  • GIT blood loss leading to iron deficiency anemia
  • Bone marrow suppression
  • Autoimmune hemolytic anemia occurs in SLE

12
Platelets and Coagulation Abnormalities
  • Autoimmune thrombocytopenia

Antiphospholipid antibodies are described in SLE
13
Metastatic malignant diseases
  • Anemia
  • Anemia of chronic disorders
  • Blood loss and iron deficiency
  • Marrow infiltration
  • Folate deficiency
  • Marrow suppression from radiotherapy or
    chemotherapy
  • hemolysis

14
(No Transcript)
15
(No Transcript)
16
cont. of Metastatic malignant diseases
  • White cell changes
  • Leukaemoid reaction
  • Malignant cells may circulate in the blood
  • WBCs changes associated with eg. Hodgkins
    disease
  • Coagulation and platelets abnormalities
  • Thrombocytosis
  • DIC
  • Acquired inhibitors to coagulation factors

17
Infection
  • Bacterial infection
  • Leukaemoid reaction
  • Severe haemolytic anemia
  • DIC
  • Chronic bacterial infection
  • E.g. TB ? anemia, secondary to marrow replacement
    and fibrosis

18
(No Transcript)
19
(No Transcript)
20
(No Transcript)
21
cont. of Infection
  • Viral infection
  • Infectious mononucleosis is associated with cold
    type autoimmune hemolytic anemia
  • Aplastic anemia secondary to hepatitis A, C, etc.
  • Acute thrombocytopenia occur in viral infection,
    e.g. EB, MCV
  • Parvovirus-B19 is usually accompanied by pure red
    cell aplasia

22
(No Transcript)
About PowerShow.com