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IMMUNOLOGY

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IMMUNOLOGY Doc. dr Du an Popadi Doc. dr Milo Markovi Ass. dr Emina Savi Prof. dr Vera Pravica imunologija_at_med.bg.ac.rs Tel. 3643-236 Facebook: Antitelija ... – PowerPoint PPT presentation

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Title: IMMUNOLOGY


1
IMMUNOLOGY
  • Doc. dr Dušan Popadic
  • Doc. dr Miloš Markovic
  • Ass. dr Emina Savic
  • Prof. dr Vera Pravica
  • imunologija_at_med.bg.ac.rs
  • Tel. 3643-236
  • Facebook Antitelija Limfocitic

2
Welcome to Immunology Course
3
Advice
  • for successful learning
  • and passing the exam

4
Immunology Course (40 hours)
Lectures (12 hrs)
Practice (Seminars and Labs 28 hrs)
5
Seminars and Labs during first 14 weeks
Lectures during first 12 weeks
Seminars, Labs and Lectures are integral parts of
the course
Student are allowed to be absent on seminar or
lab twice during the semester
6
In addition to these 40 hrs to prepare the exam
you will need 60 hours of effective work
Preparation of colloquium and final exam (45 hrs)
Preparation for lectures and practice (15 hrs)
Lectures (12 hrs)
Practise (seminars and labs 28 hrs)
7
References
  • Basic Immunology Functions and Disorders of the
    Immune System
  • Authors Abbas AK, Lichtman AH.
  • Publisher Elsevier
  • 3rd edition updated, 2011

.ppt presentations and authorised supplementary
material
(available on web site)
8
Continuous assessment
activities on the course (seminars, labs and
lectures) through activity points
presence on lectures noted separately
colloquium partial, after every 4 weeks (5th,
9th and 13th week)
9
Colloquium
Test (multiple choice 1 correct answer out of 4)
It consists of 30 questions in total (divided
into 3 mini tests) 1 point for each answer, max
30 points
15 minutes per mini test
- first in the 5th week - second in the 9th
week - third in the 13th week
Final exam
Final test with combined multiple choice and
short answer questions
Threshold for a pass is 31 points, max 60 points
10
Final mark in Immunology
Final exam mark (60)
Colloquium score (30)
Activity on seminars and labs (7)
Regularity of course attendance (3)
11
Final mark in Microbiology and Immunology
Final mark in Immunology (25) February session?
Final mark in Microbiology (75) June session?
Pass in Immunology is a condition for starting
the exam in Microbiology
12
Introduction to immune system
  • Innate and adaptive immunity
  • Types of adaptive immunity
  • Properties and phases of adaptive immune response
  • Central and peripheral lymphoid organs
  • Lymphocyte recirculation

13
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14
Principle mechanisms of innate and adaptive
immunity
15
Principle mechanisms of innate and adaptive
immunity
16
The most important cells of the immune system
17
Chain of events in infection
18
Pathogen(s) enter(s) tissue
19
Pathogen(s) enter(s) tissue
20
Pathogen(s) enter(s) tissue
21
Macrophages recognize (and eliminate) pathogens
22
Macrophages recognize (and eliminate) pathogens
23
Macrophages recognize (and eliminate) pathogens
24
Inflammation is induced and PMNs attracted
25
Inflammation is induced and PMNs attracted
26
Antigen-presenting cells (APCs) capture antigen(s)
27
Antigen-presenting cells (APCs) capture antigen(s)
28
APCs migrate to draining lymph node
29
APCs migrate to draining lymph node
30
APCs migrate to draining lymph node
31
APCs migrate to draining lymph node
32
APCs migrate to draining lymph node
33
APCs migrate to draining lymph node
34
APCs migrate to draining lymph node
35
APCs migrate to draining lymph node
36
APCs migrate to draining lymph node
37
T cells are activated by APCs
38
T cells are activated by APCs
39
T cells are activated by APCs
40
B cell are activated (helped by T cells)
41
B cell are activated (helped by T cells)
42
B cell are activated (helped by T cells)
43
Activated B cells (plasma cells) produce
antibodies (Abs)
44
Activated B cells (plasma cells) produce
antibodies (Abs)
45
Activated B cells (plasma cells) produce
antibodies (Abs)
46
Activated B cells (plasma cells) produce
antibodies (Abs)
47
Activated T cells and Abs leave lymph node...
48
... enter blood stream and...
49
... enter blood stream and...
50
... migrate to site of infection
51
... migrate to site of infection
52
... migrate to site of infection
53
Activated T cells stimulate phagocytes
54
Activated T cells stimulate phagocytes
55
Activated T cells stimulate phagocytes
56
Activated T cells stimulate phagocytes
57
Abs neutralize pathogens and stimulate phagocytes
58
Abs neutralize pathogens and stimulate phagocytes
59
Abs neutralize pathogens and stimulate phagocytes
60
Abs neutralize pathogens and stimulate phagocytes
61
Abs neutralize pathogens and stimulate phagocytes
62
Pathogen is eliminated
http//instruction.cvhs.okstate.edu/vmed5253/immun
obiology.swf
63
Principle mechanisms of innate and adaptive
immunity
64
Mechanisms of adaptive immunity
- acquired throughout a lifetime of an individual
- result of previous contact with pathogen
- present in vertebrates
65
Properties of adaptive immunity
- diversity and specificity
- memory
- clonal expansion
- specialization
- autotolerance
- stimulation of mechanisms of innate immunity
66
Types of adaptive immunity
67
Phases of adaptive immune response
68
Types of lymphocytes
69
Lymphoid organs
70
Lymph node structure
71
Lymph node structure
72
Recirculation of T lymphocytes
73
The morphology of the spleen
74
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75
Introduction to immune system
  • Innate and adaptive immunity
  • Types of adaptive immunity
  • Properties and phases of adaptive immune response
  • Central and peripheral lymphoid organs
  • Lymphocyte recirculation

76
phagocytes and NK cells
a.
Innate immunity is also called
1.
b.
humoral and cellular immunity
Mechanisms of innate immunity mediate
2.
B and T lymphocytes
c.
First line of defence of innate immunity is
provided by
3.
natural or native immunity
d.
Cells of innate immunity are
4.
diversity, specificity and memory
e.
Cells of adaptive immunity are
5.
bone marrow and thymus
f.
Types of adaptive immunity are
6.
early defence against infectious agents
g.
Important properties of adaptive immune cells are
7.
epithelial barriers
h.
Human central (primary) lymphoid organs are
8.
peripheral lymphoid organs
i.
Human peripheral (secondary) lymphoid organs are
9.
lymph nodes, spleen and MALT
j.
Primary adaptive immune response begins in
10.
1._____ 2._____ 3._____ 4._____ 5._____ 6._____ 7._____ 8._____ 9._____ 10.____
d.
g.
h.
a.
c.
b.
e.
f.
j.
i.
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