Preventing Chronic Illness with AHCC

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Active Hectose Correlated Compound (AHCC)The
Worlds Most Researched Immune Supplement
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1. Introduction
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What is AHCC?

• Naturally-derived complex compound
• Created by reacting specific enzymes with
• Several subspecies of hybridized medicinal
  mushrooms
• Unique compound formed through proprietary
  cultivation method and a patented manufacturing
  process
• Not a mushroom complex
• Cannot be duplicated and is not found in typical
  mushrooms
• Low molecular of 5,000 Daltons as compared to
  other immune ingredients
• (rice bran, beta-glucans and standard mushroom
  extracts are usually 200,000 Daltons)
• Biological response modifier with strong
  immuno-modulating properties
• Shown in scientific research to increase activity
  of white blood cells
• White blood cells protect against destroy
  abnormal cells (viruses, bacteria, parasites)
• Increased activity of Natural Killer (NK), B, B
  Helper, Killer T, Lymphokine Activated Killer
  (LAK) cells, Macrophage and Cytokines

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AHCC Production FacilitySapporo, Japan
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The Case for AHCC

• Supported by over 100 studies
• Over 4,000 patients has been involved in clinical
  trials
• Researched by over 30 prestigious institutions
  worldwide
• New studies presented annually at the AHCC
  Research Symposium
• Used in over 700 clinics worldwide
• Over 17 years of use in Japan and 6 years in the
  U.S.
• Countless anecdotal evidence
• 1 Selling Immune Supplement in Japan
• Subject of more than 10 books in Japan
• Endorsement of hundreds of physicians world-wide
• Won multiple recognitions including Nutracon Best
  Product (2002)

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Books on AHCC
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AHCC Research in the U.S.

• UT, Anderson Cancer Center
• UC, Davis Cancer Center
• Brigham and Womens Hospital (Harvard)
• Faulkner Hospital (Harvard)
• Columbia Presbyterian (Holistic Urology)
• Yale School of Medicine, Rheumatology
• SUNY Binghamton, Biological Sciences
• UT Houston Medical, Surgery
• Drexel University, Bioscience and Biotechnology

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Annual Research Symposium
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2. Science and Research behind AHCC
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The Immune System - Physiology

• Complicated series of cells that include
• Natural killer (NK-cells) Cytokines
• Macrophages Interleukins
• T and B cells Mast cells
• Substances they release
• Histamines
• Leukotrienes
• Others
• Modern science still has not yet figured it all
  out

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Misfiring of the Immune System

• Assault on the immune systems causes
• Decreased functioning of the natural killer (NK)
  cells
• Decreased functioning of the T-cells and
  macrophages
• Suppression of IL-2
• Overproduction of IL-6 and other inflammatory
  cytokines
• Long-term impact chronic illness
• The immune system plays a key part in human
  health and must be a key focus of preventative
  medicine

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Natural Killer Cells

• Serves a dual function
• Cytotoxic destroyer
• Immuno-regulator
• Sentinel cells first line of defense against
  invading pathogens (viruses, bacteria, cancer
  cells)
• Critical Role of NK cells
• Cancer sells are produced continuously in the
  body
• NK cells must remove them before they multiply

Proper functioning of NK cells is critical to
human health
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AHCC and NK Cells

• Increases NK cell activity by 300-fold
• Stimulates T-cells
• Stimulates Macrophages
• Stimulates Cytokines
• Appears to be able to stimulate and modulate
• Works on both the macrophages and the cytokines
• Valuable links and network messengers
• Can work in auto-immune disorders because it does
  not over-stimulate the immune system
• Built in dampening system
• Can be taken continuously
• Does not need to be stopped like other
  immune-enhancing supplements

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Selected Published Research
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Selected Published Research
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AHCC and Liver Disease

• Non-drug treatment of choice in Japan for
• Hepatitis C
• 10th leading cause of death in the US
• Clinically proven to Reduce Viral Load (measure
  of effectiveness) by up to 85
• Dose recommendations of 6g/day in divided doses
• Hepatocellular carcinoma
• uncommon cancer in the US
• Quite common around the world
• Can improve detoxification by inducing P450
  enzymes and inhibiting phase II enzymes
• Protects liver from chemical induced injuries
  such as
• overdose of medications ? anti-inflammatory meds
• statin drugs ? over-consumption of alcohol
• Studies show
• Extension of life
• Improvement in quality of life

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The AHCC Liver Study

• Landmark human study
• Post-surgical liver cancer patients taking AHCC
• Showed a 14 higher rate of survival than those
  in the placebo group
• Only 49 of the patients in the AHCC group had
  recurrence of cancer compared to 67 in the
  control group.

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AHCC and Immuno-senescence

• New term which has become very relevant
• Describes the deterioration of our immune system
  that occurs naturally as we age
• Increased risk of developing autoimmune disorders
• Increase frequency of infections (Pneumonia is
  still the 1 cause of death for the elderly in
  the US)
• Increased frequency of non-infectious diseases
  such as atrial fibrillation, diabetes, arthritis
  high blood pressure
• But it can be delayed and this should be a key
  focus of modern preventative medicine

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AHCC Cancer-Related Research

• Used in Asia and the U.S. to reduce side-effects
  of chemotherapy
• Reduce toxicity
• Improve quality of life
• Research supports the following modes of action
• Increases Tumor Necrosis Factor
• Increases Gamma Interferon
• Increases IL-12 (all decrease when undergoing
  chemotherapy)
• Decreases circulating level of IAP
  (Immuno-suppressive acidic protein)
• Decreases circulating level of IAP and TGF-B
  (tumor growth factorBeta)
• Multiple Studies in Japan for this Indication
• On formulary in over 700 hospitals as adjunct to
  Chemotherapy and Radiation Therapy
• Increasingly used in the U.S. with very positive
  reported results

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Other Uses of AHCC in Clinical Practice
Modulation of the cytokine defense mechanism
Raise CD-4 counts an important immune system
cellular component

• Allergies
• Asthma
• Chronic Sinusitis
• Eczema
• Fibromyalgia
• Hives
• Rashes
• Seasonal Disorders

• Post-Chemotherapy
• HIV
• Lyme Disease
• Chronic Fatigue
• Osteoarthritis
• Cold and Flu Prevention
• Cold and Flu Treatment

AHCC should be used as a daily supplement for
the immune system, alongside a multivitamin
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Why AHCC is Compelling to Physicians

• Offers an effective balance between high levels
  of stimulation of the NK cell mediated pathways
• Documented clinical and basic science research at
  prestigious hospitals around the world
• Documented efficacy studies
• Significant anecdotal evidence / positive
  response of patients
• Documented safety studies
• No toxicity
• Very few and rare side-effects

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Usage and Dosage

• Therapeutically
• Patients with highly comprised immune systems
• Recommended therapeutic dose 3g daily
• Preventatively
• Health-conscious adults seeking to heighten their
  immune activity
• Recommended preventative/therapeutic does 500mg
  1g daily

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Summary

• Biological Response Modifier with strong
  immuno-modulating properties
• Extensive clinical research
• Strong safety data
• Significant clinical usage
• Recommended for patients with
• Immune disorders
• Liver disease
• Cancer
• Undergoing chemotherapy
• Chronic illnesses
• Illnesses directly caused by inflammation
• Important for prevention of lifestyle diseases

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3. AHCC in Retail
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AHCC Unique Selling Propositions

• Unparalleled research
• over 100 studies
• over 4,000 patients
• done by the worlds most universities
• Broad adoption in Asia
• 1 Selling Immune Supplement in Japan
• Used in over 700 clinics worldwide
• Widely used by mainstream physicians in Asia and
  the U.S.
• High bioavailability due to low molecular weight,
  significantly lower than other immune supplements
  (5,000 Da vs. 200,000 Da)
• Definitive mode of action targeting Natural
  Killer and other white blood cells.

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Retailer FAQs

• Who is the target customer?
• Anyone with a weakened immune system
• Healthy individuals seeking immune enhancement
• How is AHCC different from other mushrooms and
  arabinoxylan (MGN-3)?
• Greater bio-availability due to low molecular
  weight
• Unique compound with unique properties, not a
  mushroom complex or extract
• How should I position AHCC to my customers?
• The most researched product in the immune
  category
• Used in over 700 clinics worldwide
• The 1 immune supplement in Japan, taken daily
  along a multivitamin
• What is recommended dosage of AHCC?
• 500 mg to 1 gram/day - maintenance
• 3 grams/day - therapeutic
• Is AHCC safe for children and pets?
• Yes, dose based on body weight