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Biological Explanations of Schizophrenia

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Biological Explanations of Schizophrenia Re-cap: Types of Schizophrenia Paranoid Disorganised Catatonic Undifferentiated Residual Re-cap: Types of Schizophrenia ... – PowerPoint PPT presentation

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Title: Biological Explanations of Schizophrenia


1
  • Biological Explanations of Schizophrenia

2
Re-cap Types of Schizophrenia
  • Paranoid
  • Disorganised
  • Catatonic
  • Undifferentiated
  • Residual

3
Re-cap Types of Schizophrenia
  • Paranoid delusions of persecution
  • Disorganised infantile
  • Catatonic agitated/withdrawn
  • Undifferentiated mixed
  • Residual had symptoms, but gone away

4
Diagnosis
  • One 1st Rank symptom
  • At least one other
  • How many months?
  • MEN AGES??
  • WOMEN - AGES??
  • Under 45yrs old

5
3 main categories
  • DELUSIONS
  • (illogical beliefs)
  • Persecution harm you
  • Reference personal sign
  • Grandeur you are God-like
  • Control control you

6
3 main categories
  • FORMAL THOUGHT DISORDERS
  • Vague communication
  • (change subject, confused)
  • Neologism
  • (new words)
  • Clanging
  • (illogical sounds, rhymes)

7
3 main categories
  • HALLUCINATIONS
  • Auditory
  • Tactile
  • Examples??

8
2nd Rank symptoms
  • Emotional
  • Motivational
  • Affective flattening
  • Blunted emotional expression
  • Altered sense of self
  • Who am I?
  • Puzzled
  • Behavioural disturbances
  • Waxy flexibility
  • Catatonic stupor
  • Fidgeting
  • Fiddling with things
  • Lack of concentration
  • Fixated on something

9
Biological Explanations
Genetic
Biochemical
Brain Structure
Brain
Birth
10
Genetic
  • Family Studies
  • Gottesman (1991) Concordance rates
  • General Pop 1, 1st degree relative 12, both
    parents 40
  • Twin Studies
  • GottesmanShields Concordance rates
  • MZ 42, DZ 29
  • Adoption Studies
  • Heston Inherited Vulnerability
  • 47 Schiz Mothers 16.6, 50 control group 0

Retrospective Small-scale Not 100 Environmental
factors
11
Biochemical
Neurotransmitters Dopamine
  • Weinberger Dopamine overactivity, sensitivity
    of the D2 Receptors
  • Amphetamines
  • Phenothiazones
  • PET scans
  • Autopsies
  • PARKINSONS DISEASE (L-Dopa)

12
Brain Structure
  • Torrey
  • Enlarged Ventricles
  • Latent at puberty

13
Brain
  • Berman et al.
  • Blood flow in the brain
  • McGuire
  • Brocas area in the brain
  • Hallucinations

14
Birth
  • Remember theory about ANOREXIA?
  • NEURODEVELOPMENT
  • Virus
  • Complications
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