Title: Interpreting Biomarkers in humans
1Interpreting Biomarkers in humans
- Agency for Toxic Substances Disease Registry
2Continuum for Relating Environmental
Contamination with Clinical Disease
3Limited number of biomarkers available for human
biomonitoring
- Heavy metals
- Organic compounds
4Heavy Metal Biomarkers
- Analytic methods are standardized
- Good estimate of recent exposure
- Reference ranges generally available
5Organic Compounds
- Volatile Organic Compounds
- Persistent Organic Compounds
6Biomarkers measure aggregate exposure
7Reference ranges
- Are population-based
- Do not relate to health effects
8How does one relate measurements in the
environment and biota to human measurements ?
9(No Transcript)
10PCBs in Fisherman from 2 contaminated areas
Site Catfish Large-mouth Bass Mean
SC Lake 2- 7 ppm 3-16 ppm 30 3.3 µg/L
TN
11DDT-related compounds in eggs
Sample Type DDT DDE DDD
Soil (N11) .051-1.8 .051-1.6 ND-.56
Eggs (N32) ND-.294 .023-1.81 ND-.089