Title: Comparison of Clinical Parameters for Proton Therapy in the United States
1Comparison of Clinical Parameters for Proton
Therapy in the United States
Paige Summers, MS
2Disclosure
- This project is supported by the Federal Share of
program income earned by Massachusetts General
Hospital on C06 CA059267, Proton Therapy Research
and Treatment Center and by grants CA10953 and
CA81647 (NCI, DHHS).
3RPC Background
- Funded by the NCI, tasked with ensuring that
radiotherapy institutions participating in
clinical trials deliver clinically comparable and
consistent doses - Asked to develop monitoring program for proton
therapy facilities too
4Proton Therapy Facilities
- Monitored by RPC
- 10 clinical sites
- 1 international site in Japan
- Forecast 20 new centers
- Will likely see increase in clinical trials with
proton therapy, making comparability important
NJ 2012
Shizuoka 2003
5Proton Approval Steps
- Proton facility questionnaire
- Annual monitoring of beam calibrations by the RPC
- Ability to electronically transfer treatment
plans - Irradiation of RPCs baseline proton phantoms
- On-site dosimetry review visit
6Information Collected by the RPC
- Typical review components
- Dosimetry equipment calibration
- CT scanner, CTN/RSP conversion
- Patient immobilization
- Treatment planning procedures
- QA documentation
7Patient Simulation Parameters
Institution Scanner kVp mAs Slice Thickness Acquisition Mode Pitch SFOV cm
1 GE LightSpeed RT 16 140 600 1.25 mm Axial N/A 50
2 GE LightSpeed RT 16 120 300 2.5 mm Helical 0.94 50
3 Philips PET / Big Bore 120 / 140 500 / 400 1.25 mm Helical 0.51 / 0.56 65 / 85
4 GE VCT 120 350 2.5 mm Axial/Helical N/A / 0.94 50
5 Siemens Biograph 16 PET 120 / 140 150 1 mm Helical 0.55 50
6 Siemens Sensation 120 300 1.5 mm Helical 0.75 50
7 GE LightSpeed RT 16 140 250 1.25 mm Helical 0.94 50
8 GE LightSpeed RT 16 120 300 1.25 mm Helical 0.98 50
- Values obtained during on-site audit
- Can institutions improve simulation imaging
parameters? Lower CT dose?
8Treatment Margins
- Described by institution in facility questionnaire
Site-Specific Lateral Margins mm Site-Specific Lateral Margins mm Site-Specific Lateral Margins mm Site-Specific Lateral Margins mm Site-Specific Lateral Margins mm
Brain HN Abdomen Pelvis
Institution 1 2.5 3 5 5
Institution 2 3 3 5 5
Institution 3 3 3 5 5 - 8
Institution 4 5 7 7 - 9 7
Institution 5 2 2 2 2
Institution 6 3 3 5 - 7 5 - 10
Institution 7 5 5 5 5
Institution 8 3 3 - 5 5 - 10 3 - 5
Institution 9 2 2 5 5
Institution 10 3 5 5 5
Institution 11 5 5 10 10
Penetration Uncertainty Margins Penetration Uncertainty Margins
Institution 1 3
Institution 2 3.5 3mm
Institution 3 1.50
Institution 4 3.5 3mm
Institution 5 2 mm
Institution 6 3.5 3mm
Institution 7 1 1mm
Institution 8 1.5 1.5mm
Institution 9 -
Institution 10 1 1mm
Institution 11 3.5 3mm
9Prescribing Dose
Prescription Levels Prescription Levels Prescription Levels Prescription Levels Prescription Levels Prescription Levels Prescription Levels
Brain HN Thorax Abdomen Pelvis Extremities
Institution 1 95 - 98 95 - 98 95 - 98 95 - 98 95 - 98 95 - 98
Institution 2 95 - 98 - 95 - 98 95 - 98 97.5 -
Institution 3 95 92 95 95 95 95
Institution 4 100 100 100 100 100 100
Institution 5 100 100 100 100 100 100
Institution 6 98 98 98 98 98 98
Institution 7 95 95 95 95 95 95
Institution 8 98 98 98 98 98 98
Institution 9 95 95 95 95 95 95
Institution 10 95 95 95 95 95 95
Institution 11 95 95 95 95 95 95
- Institutions normalizing in different ways, to
different levels
10Significance
- Differences exits across centers
- Task groups focusing on QA, papers on outcomes
not many recommendations about clinical
parameters - could use more recommendations from
experienced proton centers - Important to consider variation of dosimetric
parameters in planning clinical trials proton
alone or mixed modality
11Questions?
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12Proton Approval Steps
- Proton facility questionnaire
- Annual monitoring of beam calibrations by the RPC
- Ability to electronically transfer treatment
plans - Successful irradiation of RPCs baseline proton
phantoms - Successful completion of on-site dosimetry review
visit
13Facility Questionnaire
- AAPM Proton Advisory group aids RPC QARC in
updating proton facility questionnaire - Submitted to QARC via email or paper copy sent
to RPC - Questions covered
- Experiences in the clinic
- Dose calibration verification
- Proton beam production delivery
- Treatment Planning
- Immobilization
- Patient Alignment
- QA
14RPC Proton Site Visits
- Typical site visit measurements
- Beam calibration comparison RPC/Inst
- CAX lateral and depth dose profiles for reference
and patient fields - Scanning beam less fields tested, more profiles
obtained - X-ray system measurements
- TLD measurements