XIAOHUA

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?????Antianginal drugs
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• ???? (nitrate esters)
• ß????? (ß-Adrenoceptor antagonists)
  
• ?????? (Calcium antagonists)

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?.????(nitrate esters) ????(nitroglycerin)?????
??(isosorbide dinitrate) ????????(isosorbide
mononitrate)
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???????? ??????????????? NO?????,?????????,?????
?????
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??????????????? ??????
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???
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???? (nitroglycerin) ??????, 13???,??0.5??,?????
???? ?? ???? 30 ???,??3 6??,????
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??????(???) ????? ???????,??????? ???????
????????,??
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???? ???????????? ??????????
?????????????????????????????????????????????,????
???
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????????????????????????????????????????????????
???????
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ß?????(ß-Adrenoceptor antagonists)
????????????????????????? ß1??????????????????????
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????? ????
??
ß?????
??????
????????????
??????
?? ???
??????
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???????????????????????,????????????????????????
??.???????????????????
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???? ??????????????????????????
????,??????? ??????????
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???????????,???????,??????????,??ß????,???????????
???,???????
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??????(Calcium antagonists)
??????,????,????,?????????
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???? 1???????? ??Ca2??,??????,???????????,???
? ??????,???????????
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2????????? ??????????? ??????? 3?????????
????????
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???? ??????????????????,???????????????????????
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????????
ß????????????????????????????????????????????
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??????? ?? ????,?????????
,???????????????????
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ß???????????
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??? 1.   1.??????????????????? 2.    2.
?????????????????????????????????????????????????
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3.?????ß????????????????????? 4.???????????????