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(Iron Deficient Anemia, IDA)

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(Iron Deficient Anemia, IDA) 1.5 ... – PowerPoint PPT presentation

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Title: (Iron Deficient Anemia, IDA)


1
??? ??????
????? (Iron Deficient Anemia, IDA)
???
???1.5??
2
???????
1.??????????????????????????????,????,??????? 2.?
????? 3.?????????????
3
??????
IDA??? ??? ?? ???? ????? ???? ???? ??
4
????????
  • ?????

?????(iron depletion, ID)
??????? (iron deficiency erythropoiesis, IDE)
?????(iron deficient anemia, IDA)
5
???IDA????????,?????,????????????????
IDA
????IDA?????,??????????????????????????
  • ???????????(ID?IDE?IDA),??????????
  • ??IDA??????????,????????????????

6
?????
  • ??????
  • ???????????34.5?
  • ???? 65?(?23?)
  • ????
  • ???
  • ?? 30? (?11.5?)
  • ?? ????

5?(?0.150.23?)
7
???????????
  • ???????
  • ???????
  • ???
  • DNA??
  • ????
  • ????????
  • ????????????,??????
  • ????? ???????
  • ???????

8
Hepcidin??????????
  • Hepcidin??????????????
  • 2001?Park???????,???hepcidin????????????????hepcid
    in????
  • Hepcidin??????19?????,???????

9
?????
??????(Fe3) ??(Fe2)
????????b (??????????????)
???(????) ?????(???????)
???????????????????????(??hepcidin????)
?????????????????1
????????
10
? ?
  • ?????????????????
  • 2. ?????????????
  • 3. ?????
  • ????????????????IDA,????????,???????????

11
????
  • 1.???????
  • 2.??????
  • 3.??????

12
  • ??????
  • ??
  • ???????(plummer-Vinson?)
  • ????????????(pica)

13
?????
???? ??????????
14
?????
v
  • ????,???????

15
????????????????
16
???????????
  • ??????????????,??????????,?????????,?????,???????
    ?,???????????

17
?????
???lt8.95µmol/L ?????gt64.4µmol/L ???????lt15 ???
??lt12µg/L sTfRgt8mg/L
18
???????
19
(No Transcript)
20
??????????
FEPgt0.9µmol/L ZPPgt0.96µmol/L FEP/Hbgt4.5µg/gHb
??????????????????????????????????,?ZPP???IDA???
21
????
ID
IDE
IDA
?????lt12µg/L
??????????? ?????,?????lt15
???????lt15
FEP/Hbgt4.5µg/gHb
????????
?????????
????
22
????
??????,IDA?????
?? 1. ???????????????????????IDA,?????????,??????
?X?????? 2. ????????????????
23
????
  • ?????????
  • 1.????????
  • ?????????????????????
  • ???????????????,???????????????????,???????
  • ???????????????????

24
????????
  • ??????????????????,?????

25
2.?????
  • ????,?????,???,??
  • ?????????
  • ???????????HbF??HbA2?
  • ????????????????
  • ??????

26
3.??????(anemia of chronic disease,ACD)
  • ?????????????????
  • ?????????????????
  • ???????????????

27
ACD?????
  • ???????
  • ?????
  • ??????(EPO)??
  • ????????

28
  • 1.????????????????-????
  • 2.?????(????),?????(TIBC)
  • ??,???????(TS)?????(??gt16,?IDAlt15)
  • 3.?????(SF)??
  • 4.????,???????,????????
  • 5.????????????????

ACD ? ? ? ?
29
ACD?IDA???
?? ?? ??? IDA ACD
??? ??? ???
µg/dl 70 160 30 30 TIBC
µg/dl 250 340 400 200 TS
30 7
15 ?????? 0
SF µg/dl 20 200 10
150 ??TfR nmol 8 28
??
30
ACD???
  • 1.????,??????
  • 2.EPO30006000 U/?,??3?/W,?HCT?36
  • 3.?????????
  • 4.????,???????
  • ????VitB12??????

31
IDA???
  • ????,????
  • 1.????
  • 2.????

32
????
  • ??????
  • ????????
  • Hb??????????,????36?
  • ????????
  • ??????????????
  • ????,??????

33
?????
1.?????????????? 2.????????????
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