Avian influenza The pandemic threat ?????????? ??????? ?????? ???? ???? ?????? - PowerPoint PPT Presentation

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Title:

Avian influenza The pandemic threat ?????????? ??????? ?????? ???? ???? ??????

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Avian influenza The pandemic threat – PowerPoint PPT presentation

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Title: Avian influenza The pandemic threat ?????????? ??????? ?????? ???? ???? ??????


1
Avian influenza The pandemic threat??????????
??????? ?????? ???? ???? ??????
2
Influenza
  • ?? ?????? ????? ???? ????? ?????? ???.
  • ????????? ?? ?? ??? 1510 ?????? ????? ??? ???.
  • ?? ??? ????? ????? 3 ?????? ??????.
  • ?????? ?????? 1919-1918 40 ?????? ??? ?????? ????
  • ????? ????????? ?? ??? 1933 ????? ??

3
Influenza Virus
  • ????? ?? ??? A,B,C
  • ??? ??????? ??? A ???? ???? ?????
  • Hemagglutinin ?Neuraminidase ?? ?? ?????? ??
    ????
  • ????? (H1N1) ?? (H3N2)
  • ???? ?????????? ??????? ?? ??? ???? ??? H5 ? H7
    ?? ????
  • ????? H5N1

4
Influenza virus
5
  • Influenza Virus

6
??????? ???? ???? ?????
  • Antigenic Drift (??????? ????)
  • Antigenic Shift(??????? ????)

7
(No Transcript)
8
?????? ??? ??? ?????
  • 1919-1918 ????? ?? ?????????? ????????? A (H1N1)
  • 50 -20?????? ??? ?? ????? ????
  • ???? ?? ???????? ????? ???? ? ???? ?????

9
(No Transcript)
10
  • ?? ????? ????? ???? ??? ? ???? ????? ?????? ????
    ????? ?? ?? ???? ?? ?? ??? ??? ?? 40 ?????? ???
    ???? ???? .
  • ????? ????? ?? ??? ?????? ??? ?? 5 ????? ?????
    ??????? ?? ??? ????? ??? ???? ??? .
  • ???? ?????? ?? ??? ?? ?? ? ?? ??? ?? ?? ?????
    ???????? ??? .

11
?????? ??? ??? ?????
  • 1957-1958????? ?? ?????????? ??????A (H2N2)
  • ?????? ?? ????? 1957 ?? ??? ???? ??
  • ?? 5 ??? ?????? ?? ?????? ????

12
?????? ??? ??? ?????
  • 1968-1969 ????? ?? ?????????? ??? ???
  • A (H3N2)
  • ?? ????? ??? 1968 ?? ??? ??? ???? ??
  • ?? ?? ??? ?? ???? ???? ????? ??
  • H3N2???? ?? ??? ???? ?? ???? ???

13
(No Transcript)
14
????? ?????? ??
  • ???? ???????? ????????? ?? ??? ???? ???? ???? ??
    ???? ?? ?? ????? ??????? ???????
  • ?????????? ????? ????? ??? ?? ?????? ???? ????
    ????? ?????

15
Cycle of Avian Influenza Viruses in Animals
Humans
Direct bird to human transmission is also common.
16
(No Transcript)
17
?????? ?????? ?????????-?????? ???? ??
  • ?????
  • ????? A/H3N2 A/H1N1
  • ????? A/H3N2 B
  • ????? A/H3N2 A/H1N1
  • ????? A/H1N1
  • ????( ??????? ??????? ??????)A/H3N2 A/H1N1B
  • 11 ???? ?????????? A/H1N1 ? 8 ???? ??????????
    A/H3N2
  • ? 6 ???? ?????????? B ????? ???? ??.

18
?????? ??? ?????? ????????? ???? ????? ???
  • ??? ???? ??? ???? ???? ???? ?????? ?????????
  • ???? ?????? ????? ????
  • ???? ???? ????? ???? ???? ????? ?? ??????? ??????
    ???
  • ????? ?????? ?? ???? ????? ?? ????? ?? ????.
  • ????? ?????? ???? ?????? ?? ????? ????? ?????
    ???? ?? ?? ???? ??? .
  • ????? ?????? ??????? ? ??????? ?????? ??????

19
??????? ?????????? ???????
  • ????? H5N1 ????? ??? ?? 1961?? ??????? ????? ??
    ??????? ??? ??
  • ????? ???? ??????? H5N1 ???? ??? ?? ??? ???
    ????????? ??
  • HPAI (Highly Pathogenic Avian Influenza) ??????
  • ????????? ???? ?? H5N1 ?? ?????? 2003 ? 2004 ??
    ??? ???? ??????
  • ???? ?? ????? ??? ?? 100 ?????? ???? ???? ??.

20
??????? ?????????? ???????
  • ?? ??? ???? ?????? ??????? ?? ??????? ?????
    ???????? ?
  • ????? ? ????? ? ?????? ?? ????? ??? ???
  • ??????? ????? ??? ???? ?? ?????? ????? ?????.

21
(No Transcript)
22
(No Transcript)
23
????? ?????? ?? ???????
  • Virulence
  • Dependant on virulence of virus, species affected
    and other environmental conditions
  • HPAI
  • Often no clinical signs other than sudden death
  • Possible signs of illness
  • Soft-shelled eggs Depression
  • Cyanosis of wattle and combs Diarrhea
  • Loss of appetite Respiratory distress

24
(No Transcript)
25
(No Transcript)
26
????? ?????? ?????? ?? H5N1
  • ?? ??? 1997???? ????? ??? 18 ???? ?????? ??????
    ?? 6 ???? ??? ?? ??? ??? ????? ??
  • ????? ????? ?????? ?????? ?? ???? ???? ???????
    ??????? ??????
  • ? ??????? ????? ??? ???
  • ?? ???? ?????? 122 ???? ?????? ?????? ?? ??? ?
    ??? 50 ????? ??? ???

27
???? ????? ?????? ?????? H5N1
????? ??? ????? ????? ????
4 4 ??????
4 7 ???????
13 20 ??????
41 91 ??????
62 122 ???
28
???? ?????? ??????
  • ???? ??? ?????? ?????? H5N1 ?? ????? ?? ???
  • ????? ?? ???? ? ?????? ???? ? ????? ??????? ????
    ????
  • ???? ????? ?????? ?????? ?? ???
  • ???? ?? ??????? ????? ? ???? ????? ???? ???

29
????? ?????? ?? ?????
  • ????? ???????? ?? ??????????H5N1 ?? ?????
    ?????? ?? ???? ?? (38 ???? ?? ?????) ????
    ??????? ?? ???? ?????? ? ???? ????? ???? ???
    ?????. ?? ?????? ????? ? ????? ???? ?? ?????
    ????? ?????? ???? ?? ????? ???? ?? ???? ??? ??
    ????? ????? ????? ?? ????. ???? ??????? ??? ????
    ? ???? ? ????? ??? ?????. ?? ?? ???? ??????? ??
    ????? ???????????? (????? ????) ???? ????? ?????
    ?????? ????? ???.

30
(No Transcript)
31
????? ?????? ?????? ?? H5N1
  • ????? ?????? ????? ?? ????? ?? ???? ????? ?????
    ???? ??? ??? ????? ?? ????? ???? ??? ????? ???.
  • ???? ??????? ?? ?????? ????? OSELTAMIVIR
  • ???? ??? ?? ??????? ? ?? ????? ?????
    ???? ???? ????

32
(No Transcript)
33
(No Transcript)
34
(No Transcript)
35
(No Transcript)
36
  • ????? ???
  • 1- ???? ??? ?? H5N1 ?? ???? ???????? ????
    ??????? ??? ? ??? ??????? ?? ???? ?? ?? ???????
    ???? ?????? ?? ????? ????? ??? .
  • 2- H5N1 ?? ????? ????? ?????? ???? ?? ??? ? ???
    ???? ???? ?? ???.

37
Influenza virus reassortment
Flu virus 1
Novel virus strain
double/mixed infection
Flu virus 2
38
(No Transcript)
39
(No Transcript)
40
  • ???????? ???? ???? ?? ??? ?? ???????? ??? H5N1 ?
    ????? ????? ?????? 1918 ???? ???? .
  • ???? ??? ??? ?????? 1957 ? 1968 ????? ???????
    ???? ??? ????? ?????????? ?????? ? ????? ?? ????
    ??? .

41
  • ?? ????? ??? ???? ????? ???? ?????? ??? ??
  • ?????? ????? ?? ?????? ????
  • ? ????? ?? ??? ???? ????

42
????? ?????? ????????? ?? ??? WHO
43
????? ???? ?????
  • ???? ????? ?? ?????? ??????? ?? ????? ???? ????
    ???
  • ???????? ????? ?? ???????? ?? ??? ????? ????
    ?????? ????? ???.

44
??????? ?? ???? ???
  • ??????? ?????????? ????? ????? ???? ? ??????? ?
    ??????
  • ???????? ?? ?? ?????? ?? ????? ???? ??????? ????
    ??? ?????
  • ????? ?? ?? ????? ??? ???? ??????? ???? ??? ??
    ????

45
??????? ?? ???? ???
  • ?????? ? ????? ????? ?? ?? ?????? ???? ???? ??
  • ????? ???? ??? ?? ? ??? ?????
  • ????????? ??????? ??? ????
  • ????????? ???? ?? ???? ????

46
??????? ?? ???? ???
  • ??????? ???????????? ?????????
  • ????? ???? ?? ?????? ?? ??? ?????? ????? ?
    ??????? ???? ??? ?? ?? ?????? ?? ???? ???
  • ????? ?????? ?? ????? ????? ?........
  • ???????? ? ???? ?????? ?? ?? ??????? ????? ??
    ???? ???? ?? ???? ?????

47
??????? ??? ?? ???????? ?????
  • ???? ??????? ?????? ??OSELTAMIVIR
  • ?? ??????? ??????? ????? ?? ???? ?? ???????
  • ??????????? ?????? ?? ???? 5 ???????
  • ????? ???? ? ??????? ?? ????? ?? ????? ?????

48
??????? ??? ?? ???????? ?????
  • ????? ???? ?? ????? ????? ??? ????? ????
  • ????? ????? ????? ????? ?? 24 ???? ?? ?? ??? ??

49
????????? ??????? ???? ?????
  • ??????? ??? ???? ?? ????????? ????? ?? ????
    ???????? ? ???? ???? ?????? ????? ?? ?????? ?????
    ???????? ?????? ??????? ? ????? ??????? ???? ????
    ?????? ?? ????? ????? ?? ?? ?????
  • ????? ???? ????????
  • ??? ????? ?? ???? ??????? ?????? ? ????? ? ?????
    ???????
  • ????? ????? ???? ???? ???? ?? ???? ????????? ?
    ?????? ??????? ? ??? ??????????? ? ??? ?????

50
????????? ??????? ???? ?????
  • ????? ??????? ??? (???? ??????? ??????
    ????????? ???? ????????? ? ?????? ?? ?? ??? ????
    ?? ???? ?? ???? ?????)
  • ????? ???? ? ?????
  • ????????? ?????????? ???? ????? ?????
  • ??? ?????? ????????? ????????? ????
  • ??????? ?????? ?????? ????? ?? ????? ? ?????
    ?? ?? WHO
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