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Title:

Influenza A

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Title: Influenza A Genetic Surveillance Author: K.Fonseca Last modified by: Faculty of Medicine Created Date: 3/7/2012 4:37:57 AM Document presentation format – PowerPoint PPT presentation

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Date added: 4 July 2019
Slides: 21
Provided by: KFon5
Learn more at: http://www.tarrantviralwatch.ca
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Title: Influenza A


1
Influenza A Whats Hot
  • TARRANT Symposium 2012
  • Kevin Fonseca
  • Clinical Virologist
  • ProvLab
  • Kevin.fonseca_at_albertahealthservices.ca

2
Theme
  • Recent Controversies in Influenza Research
  • Animal Models
  • Lively Discussion

3
Holy Grail of Influenzaologists
  • The Perfect Vaccine
  • Able to predict Pandemics to the day/hour
  • Able to clinically diagnose with 100 certainty
  • The Perfect Influenza test in 10 secs
  • The Perfect Model

4
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5
Influenza A H5N1 Disease
  • Acquired from infected poultry
  • Person-to-person transmission rare
  • Aggressive severe disease in humans
  • Mortality at least 60
  • Affects healthy young individuals
  • Begins as a respiratory disease, progressing to a
    viral pneumonia and multi-organ failure
  • Treatment may not prevent death
  • ?Potential mortality in a pandemic

6
Controversy
  • Balance the right to research with perceived
    ethical obligations
  • Create a potential bio-weapon
  • Provide data to terrorist organisations
  • Risks of pathogen escape (small-pox, anthrax,
    influenza)
  • Safety of the public
  • What about military research
  • When is research just to dangerous to conduct
  • Does understanding the biology of infection in
    animal models really help ?

7
Mortality 58
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11
Belser et al Disease Models Mechanisms 2011
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14
Pandemic vs Seasonal H1N1 (Pre-pandemic)
Virus Ferrets Humans
Pandemic Mild Severe Fatal 30 sneezed No deaths Found in GI (70) Generally mild Not associated with GI symptoms Lots of person-to-person transmission Spectrum of illness with some fatalities Some countries reported higher incidences or morbidity mortality
Pandemic Mild Severe Fatal 50 sneezed 50 died Found in GI (20) contacts Generally mild Not associated with GI symptoms Lots of person-to-person transmission Spectrum of illness with some fatalities Some countries reported higher incidences or morbidity mortality
Pandemic Mild Severe Fatal 10 sneezed No deaths Found in GI (10) Generally mild Not associated with GI symptoms Lots of person-to-person transmission Spectrum of illness with some fatalities Some countries reported higher incidences or morbidity mortality
Seasonal 100 sneezed No deaths No GI infection Generally mild No GI symptoms Fatalities occurred
Q How accurate was the ferret model in
predicting human disease ?
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20
Reality ?
  • Observed
  • Handful of cases (12)
  • Mainly in young children
  • Mild illness
  • Few hospitalizations
  • Low level of transmission thus far
  • ? Pandemic potential?
  • Not covered by the vaccine
  • Ferret Model
  • A(H3N2)v is easily transmissible
  • Causes mild illness
  • Human Cell Model
  • A(H3N2)v gt H3N2
  • Reaches a higher titre

21
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