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Carroll-Wang Biology Research Group Department of Statistics http://stat.tamu.edu/~carroll

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Title: Analysis of DNA Damage and Repair in Colonic Crypts Author: carroll Last modified by: carroll Created Date: 10/3/2003 9:26:05 AM Document presentation format – PowerPoint PPT presentation

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Title: Carroll-Wang Biology Research Group Department of Statistics http://stat.tamu.edu/~carroll


1
Carroll-Wang Biology Research Group Department of
Statistics http//stat.tamu.edu/carroll
Raymond Carroll, carroll_at_stat.tamu.edu
Naisyin Wang, nwang_at_stat.tamu.edu
2
What We Do
  • Our Aim Develop statistical methods for analysis
    of diet and cancer relationships, especially
    colon cancer
  • Cell and molecular biology based studies
  • Functional, computational, high-dimensional data
    analysis

3
Where Does the Nutrition Come In?
  • We work with Drs. J. Lupton, N. Turner and R.
    Chapkin of Nutrition
  • Generally, there are two diets
  • One rich in Corn oil
  • Other rich in Fish oil
  • The Fish oil diet is protective for colon cancer
    the data are striking
  • Our goal is to answer why this is the case

4
About Me
  • I grew up in Wichita Falls, Ph.D. from Purdue, 13
    years at UNC, then here as head of department
    from 1987-90
  • I have been working on nutrition and cancer for
    15 years
  • I continue work with NCI Researchers on
    Nutritional Epidemiology and AM researchers on
    basic Biology

5
About Naisyin Wang
  • From Taiwan, Ph.D. from Cornell in 1991
  • Our 1st female Full professor
  • Faculty Fellow
  • Elected Fellow of the American Statistical
    Association
  • Associate editor of multiple scientific journals
  • Has worked with me since her arrival here

6
Some Statistics
  • Basic Research Grants
  • We each are P.I.s on National Cancer Institute
    grants
  • Bioinformatics Training Grant
  • P.I. and primary co-investigator
  • NIH Center for Environmental and Rural Health
  • P.I. of Biostatistics Core
  • Impact on Nutrition and Colon Cancer Research
  • Biostatisticians on multiple grants

7
Our Graduate Students
Zonghui Hu, DNA adducts
Gosia Leyk, Oxidative Damage
Tanya Apanasovich, Aberrant Crypt Foci
Christie Spinka, Genetic Epidemiology
Veera Baladandayuthapani, Gene interactions
8
Architecture of Colon Crypts
  • Stem Cells
  • Mother cells near bottom
  • Depth in crypt age of cells
  • Suggests importance of depth
  • We see these location effects in all our work
    statistically interesting

Lumen
crypts
9
Analysis of DNA Repair in Colonic Crypts
This work (with Marina Vannucci) has won two
honors Editors Invited paper, 2003, JASA (the
major journal in the field) Mitchell Prize for
Bayesian methodology The first development of
wavelets in hierarchical functional data
10
Other Current Hierarchical, Funcational Data
Projects
Flare Image Analysis for Oxidative damage
Aberrant Crypt Foci Spatial clustering
Multiple biomarkers per cell, and spatial
clustering
11
The Bioinformatics Training Program
  • Naisyin and I realized in 1999 that few
    statisticians knew anything about basic molecular
    biology
  • The communication difficulties are real how many
    non-statisticians know the buzzword Functional
    Data Analysis?
  • How many statisticians know about Apoptosis
    (programmed cell death)?

12
The Bioinformatics Training Program
  • We enlisted help from colleagues in
  • Nutrition
  • Electrical engineering
  • Toxicology
  • Biochemistry
  • We obtained an NCI grant
  • We recruit
  • Statisticians
  • Electrical engineers

13
Current Trainees
Wenjiang Fu, Michigan State, Microarrays for DNA
expression (Tai Hsing)
Mahlet Tadesse, Harvard, Microarrays (M. Vannucci)
Kimberley Drews, Texas Tech, Cell gene
expression profiles (RJC)
Ivan Ivanov, Central Florida, Gene regulatory
networks (E. Dougherty)
14
The Bioinformatics Training Program
  • The program consists of
  • Coursework in biology, nutrition and genetics
  • Mentoring in life sciences labs
  • Kimberley Drews (Joanne Lupton, Nutrition)
  • Mahlet Tadesse (Ken Ramos, Toxicology)
  • Ivan Ivanov (Jerry Tsai, Biochemistry)
  • Wenjiang Fu (Guoyao Wu, Nutrition)

15
The Bioinformatics Training Program
  • Two trainees have finished the program
  • Danh Nguyen, now in the Bioinformatics Research
    Group at UC-Davis
  • Aniruddha Datta, now in Electrical Engineering at
    TAMU
  • In addition, there are 7 graduate students that
    were partially supported by the VPR office
  • They also do the training, courses, etc.

16
The Bioinformatics Training Program
  • You will next hear from one of the postdoctoral
    trainees, Dr. Mahlet Tadesse, and her statistical
    mentor, Associate Professor Marina Vannucci
  • They will describe how the training program works
    and their joint research that has resulted from
    it.
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