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National Pediatric Critical Care Collaborative Research Network

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... to critical illness and its management Minimizing the effect on siblings and families of devastating childhood illness Reintegration of child into home, ... – PowerPoint PPT presentation

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Title: National Pediatric Critical Care Collaborative Research Network


1
National Pediatric Critical Care Collaborative
Research Network
  • Carol E. Nicholson, MD
  • NIH/NICHD/NCMRR
  • Pediatric Critical Care and Rehabilitation
    Research

2
Vision
  • a collaborative pediatric critical care research
    network of interactive clinical and translational
    science research groups.

3
Purpose and Vision -I
  • promote the efficient comparison of novel
    critical care treatment methods and management
    strategies of potential benefit for children and
    who are critically ill and/or injured.

4
Purpose and Vision-II
  • Fund the infrastructure required for a network of
    six core clinical centers to perform clinical
    trials, translational and descriptive research
    in pediatric critical illness and injury

5
Purpose and Vision- III
  • Seek descriptive and translational science in the
    pathophysiology of critical illness in children,
    especially

6
In survivors of childhood critical illness.
  • Linking outcomes (functional and developmental)
    to critical illness and its management
  • Minimizing the effect on siblings and families of
    devastating childhood illness
  • Reintegration of child into home, school, family
    as the ultimate goal of critical care practice

7
In the subspecialty.
  • Understanding the pathophysiology of critical
    illness, particularly multiple organ system
    failure (MOSF)
  • Evaluating practice our own, other specialties
    caring for children.
  • Finding adequate outcome measures of pediatric
    critical care practice

8
How will the Network be Constituted ?
  • Up to six core clinical centers
  • Data Coordinating Center
  • NICHD assistance
  • Project Officer
  • Project Scientist
  • Steering Committee
  • Chairman

9
The Money.
  • Total amount of set-aside 5M (years 2-5)
  • 1M Data Coordinating Center (separate RFA)
  • To fund core clinical centers 4M

10
How much each, for what?
  • Infrastructure operating costs
  • Each center direct costs
  • First year 100,000
  • Years 2-5 450,000
  • Full time research nurse
  • 10-15 PI time
  • Half time data entry /administrative staff

11
To qualify, these centers MUST..
  • HAVE STRONG FOLLOWUP of CHILDREN who have
    devastating illness or injury
  • Your longer term care colleagues are looking for
    you.get involved!

12
Governance of the Network
  • Steering Committee
  • consists of
  • PIs
  • NICHD Project Scientist
  • DCC PI
  • Chairman (NICHD appointed)

13
Choosing a Funding Mechanism
14
What is a Cooperative Agreement?
  • Substantial NICHD scientific and/or programmatic
    involvement with the recipient is anticipated.
  • An award instrument establishing an "assistance
    relationship between the NIH institutes (NICHD)
    and a recipient.

15
To Clarify, a bit.
  • NICHDs purpose in this relationship
  • to support and/or stimulate the recipient's
    activity by involvement in and otherwise
    facilitating the activity in a "partner" role
  • avoid a dominant role, direction, or prime
    responsibility.

16
How will applicants be evaluated?
  • Three areas
  • Characteristics of the Proposed Center
  • Principal Investigator and Identified Research
    Nurse
  • Proposed Science

17
Review of Applications
  • CRITERIA include
  • Significance
  • Approach
  • Investigator
  • Environment
  • Additional Review Criteria in RFA

18
The review will be by a SEP
  • Special Emphasis Panel, convened by NICHD just
    for this purpose.
  • The Scientific Review Administrator will select
    and invite the review committee members
  • Not all members of the review group will be
    intensivists

19
Looking at the three aspects of the application
to be submitted
  • A paradigm preparing to board the train
  • Is it the right train for you?
  • Dont get on the train to New York if you want to
    get to Kansas City

20
Characteristics of the Center






  • A table of the characteristics of your pediatric
    critical care service
  • of patients in each category
  • Institutional personnel and services

21
Principal Investigator and Research Nurse
  • Evidence of commitment to research
  • Evidence of commitment to collaboration
  • Research Nurse must be identified at the time of
    application
  • Each Principal Investigator must be a fully
    qualified pediatric intensivist.

22
Dont let the timing bother you.
  • Publication April, 2004
  • Applications due August 9, 2004
  • Anticipated funding Spring, 2005

23
..Summer, 2004
  • Due date August, 2004
  • start now, so that summer is peaceful, and the
    Network applications begin to

24
Develop with passion and precision
25
help one another get started
26
Things to do first!
  • Identify research nurse and princicpal
    investigator
  • Get buy-in at your institution.is this the right
    train for you? Ask the neos
  • Identify the science you will propose and begin
    the SEVEN STEPSmake your notebook
  • You will need to know ages and diagnostic
    categories of PICU patients..

27
California Dreamin
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