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Welcome to Immunology Course

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Welcome to Immunology Course Phases of adaptive immune response Types of lymphocytes Lymphoid organs Lymph node structure Lymph node structure Recirculation of T ... – PowerPoint PPT presentation

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Title: Welcome to Immunology Course


1
Welcome to Immunology Course
2
IMMUNOLOGY
  • Prof. dr Vera Pravica
  • Prof. dr Dušan Popadic
  • Doc. dr Miloš Markovic
  • Assist. dr Emina Savic
  • imunologija_at_med.bg.ac.rs
  • Tel. 3643-236
  • Facebook Antitelija Limfocitic

3
Advice
  • for successful learning
  • and passing the exam

4
Immunology
  • independent subject (separated from
    Microbiology)
  • winter semester
  • 45 hours during 15 week

Lectures (15)
Seminars (20)
Labs (10)
5
Seminars, Labs and Lectures are integral parts of
the course
Student are allowed to be absent on seminar or
lab twice during the semester
6
Textbook
  • Basic Immunology Functions and Disorders of the
    Immune System
  • Authors Abbas AK, Lichtman AH.
  • Publisher Elsevier
  • 3rd edition updated, 2011

.ppt presentations and authorised supplementary
material
(available on web site)
7
Continuous assessment
Activity during the course (seminars, labs and
lectures) through activity points
Presence on lectures noted separately
Colloquium divided in three separate mini-tests
after every 4 weeks (5th, 9th and 13th week)
Final test
8
Colloquium
Test (multiple choice 1 correct answer out of 4)
It consists of 30 questions in total (divided
into 3 mini tests with 10 questions each)
  • first in the 5th week (first 4 chapters from
    the textbook)
  • second in the 9th week (chapters 5 to 8)
  • third in the 13th week (chapters 9 to 12 plus
    immunological methods and vaccines)

1 point for each correct answer (max 30 points)
15 minutes per mini test
9
Final test
  • 70 points in total
  • consists of
  • 20 multiple choice questions with one correct
    answer out of four
  • (2 points for each correct answer, max. 40
    points)
  • 5 fill-in questions where correct word should
    be filled in the blanks
  • (max. 20 points)
  • 2 questions that require short answers up to
    five sentences
  • (max. 10 points)

Threshold for passing the final test is 36 points
(50 plus 1)
10
Final mark in Immunology
For the passing of the Immunology exam the
minimum of 51 points (out of 100) should be
collected on condition that the 50 of points
plus one (minimally 36) has been reached in the
final test Note If the student collected less
than 15 points in colloqium (i.e. 50),
he/she must perform better than 36 in the final
test 100 points in total 51-60 6
(six) 61-70 7 (seven) 71-80 8
(eight) 81-90 9 (nine) 91-100 10
(ten) Activity points (max. 10 points) are
added only if the minimum of 51 points has been
reached
11
Introduction to immune system
  • Innate and adaptive immunity
  • Types of adaptive immunity
  • Properties and phases of adaptive immune response
  • Central and peripheral lymphoid organs
  • Lymphocyte recirculation

12
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13
Principle mechanisms of innate and adaptive
immunity
14
Principle mechanisms of innate and adaptive
immunity
15
The most important cells of the immune system
16
Chain of events in infection
17
Pathogen(s) enter(s) tissue
18
Pathogen(s) enter(s) tissue
19
Pathogen(s) enter(s) tissue
20
Macrophages recognize (and eliminate) pathogens
21
Macrophages recognize (and eliminate) pathogens
22
Macrophages recognize (and eliminate) pathogens
23
Inflammation is induced and PMNs attracted
24
Inflammation is induced and PMNs attracted
25
Antigen-presenting cells (APCs) capture antigen(s)
26
Antigen-presenting cells (APCs) capture antigen(s)
27
APCs migrate to draining lymph node
28
APCs migrate to draining lymph node
29
APCs migrate to draining lymph node
30
APCs migrate to draining lymph node
31
APCs migrate to draining lymph node
32
APCs migrate to draining lymph node
33
APCs migrate to draining lymph node
34
APCs migrate to draining lymph node
35
APCs migrate to draining lymph node
36
T cells are activated by APCs
37
T cells are activated by APCs
38
T cells are activated by APCs
39
B cell are activated (helped by T cells)
40
B cell are activated (helped by T cells)
41
B cell are activated (helped by T cells)
42
Activated B cells (plasma cells) produce
antibodies (Abs)
43
Activated B cells (plasma cells) produce
antibodies (Abs)
44
Activated B cells (plasma cells) produce
antibodies (Abs)
45
Activated B cells (plasma cells) produce
antibodies (Abs)
46
Activated T cells and Abs leave lymph node...
47
... enter blood stream and...
48
... enter blood stream and...
49
... migrate to site of infection
50
... migrate to site of infection
51
... migrate to site of infection
52
Activated T cells stimulate phagocytes
53
Activated T cells stimulate phagocytes
54
Activated T cells stimulate phagocytes
55
Activated T cells stimulate phagocytes
56
Abs neutralize pathogens and stimulate phagocytes
57
Abs neutralize pathogens and stimulate phagocytes
58
Abs neutralize pathogens and stimulate phagocytes
59
Abs neutralize pathogens and stimulate phagocytes
60
Abs neutralize pathogens and stimulate phagocytes
61
Pathogen is eliminated
http//instruction.cvhs.okstate.edu/vmed5253/immun
obiology.swf
62
Principle mechanisms of innate and adaptive
immunity
63
Mechanisms of adaptive immunity
- acquired throughout a lifetime of an individual
- result of previous contact with pathogen
- present in vertebrates
64
Properties of adaptive immunity
- diversity and specificity
- memory
- clonal expansion
- specialization
- autotolerance
- stimulation of mechanisms of innate immunity
65
Types of adaptive immunity
66
Phases of adaptive immune response
67
Types of lymphocytes
68
Lymphoid organs
69
Lymph node structure
70
Lymph node structure
71
Recirculation of T lymphocytes
72
The morphology of the spleen
73
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74
Introduction to immune system
  • Innate and adaptive immunity
  • Types of adaptive immunity
  • Properties and phases of adaptive immune response
  • Central and peripheral lymphoid organs
  • Lymphocyte recirculation

75
phagocytes and NK cells
a.
Innate immunity is also called
1.
b.
humoral and cellular immunity
Mechanisms of innate immunity mediate
2.
B and T lymphocytes
c.
First line of defence of innate immunity is
provided by
3.
natural or native immunity
d.
Cells of innate immunity are
4.
diversity, specificity and memory
e.
Cells of adaptive immunity are
5.
bone marrow and thymus
f.
Types of adaptive immunity are
6.
early defence against infectious agents
g.
Important properties of adaptive immune cells are
7.
epithelial barriers
h.
Human central (primary) lymphoid organs are
8.
peripheral lymphoid organs
i.
Human peripheral (secondary) lymphoid organs are
9.
lymph nodes, spleen and MALT
j.
Primary adaptive immune response begins in
10.
1._____ 2._____ 3._____ 4._____ 5._____ 6._____ 7._____ 8._____ 9._____ 10.____
d.
g.
h.
a.
c.
b.
e.
f.
j.
i.
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