Microfiltration Introduction and Model

1
Microfiltration Introduction and Model

• David Shonnard
• Department of Chemical Engineering
• Michigan Technological University

2
1. Removal of Insoluble ProductsMicrofiltration
for Removal of Cells

• Mass balance model for separation of cells
• (cells are retained in the feed tank
• by recycling the retentate
• stream back to the feed
• tank)

Chandrasekaran, R., MS Thesis, Dept. of Chemical
Engineering MTU
qR,CR
Retentate
MF Membrane
Permeate
qP, CP
Feed Tank
VF(t)
MF Cassette
Permeate Tank
Feed
VP(t)
qF, CF
3
1. Removal of Insoluble ProductsMicrofiltration
for Removal of Cells
Chandrasekaran, R., MS Thesis, Dept. of Chemical
Engineering MTU
4
1. Removal of Insoluble ProductsMicrofiltration
for Removal of Cells
Chandrasekaran, R., MS Thesis, Dept. of Chemical
Engineering MTU
5
1. Removal of Insoluble ProductsMicrofiltration
for Removal of Cells
Chandrasekaran, R., MS Thesis, Dept. of Chemical
Engineering MTU
6
1. Removal of Insoluble ProductsMicrofiltration
for Removal of Cells
Chandrasekaran, R., MS Thesis, Dept. of Chemical
Engineering MTU
7
1. Removal of Insoluble ProductsMicrofiltration
for Removal of Cells
Chandrasekaran, R., MS Thesis, Dept. of Chemical
Engineering MTU
8
1. Removal of Insoluble ProductsMicrofiltration
for Removal of Cells
mFo
Chandrasekaran, R., MS Thesis, Dept. of Chemical
Engineering MTU
mF
t
9
1. Removal of Insoluble ProductsMicrofiltration
for Removal of Cells
Chandrasekaran, R., MS Thesis, Dept. of Chemical
Engineering MTU
CF
t
10
1. Removal of Insoluble ProductsMicrofiltration
for Removal of Cells
Perfectly Permeating Species (L-lysine)
Chandrasekaran, R., MS Thesis, Dept. of Chemical
Engineering MTU
CF
mF
t