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NCI Perspective on Nanomedicine and Nanobiology

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Title: NCI Alliance for Nanotechnology in Cancer: Research Advances and Development of Clinical Applications Last modified by: Larry Nagahara Document presentation format – PowerPoint PPT presentation

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Title: NCI Perspective on Nanomedicine and Nanobiology


1
  • NCI Perspective on
    Nanomedicine and Nanobiology
  • Larry Nagahara, Ph.D.
  • Nanotechnology Projects Manager
  • National Cancer Institute
  • Grand Challenges for Nanomedicine and Nanobiology
    Workshop
  • August 27, 2007

2
  • 560,000 Americans will die of cancer this year
  • 1,300,000 Americans will hear the words you
    have cancer this year
  • 185 billion per year on healthcare costs for
    cancer in the U.S. alone

3
We Must Accelerate Progress Against Cancer
Early Diagnostics Is Key
Early Diagnostics Is Key
4
NCI Websitehttp//www.cancer.gov/
5
NCI Strategic Objectives and Progress
To Preempt Cancer at Every Opportunity
  • Understand the Causes and Mechanisms of Cancer
  • Accelerate Progress in Cancer Prevention
  • Improve Early Detection and Diagnosis
  • Develop Effective and Efficient Treatments

To Ensure the Best Outcomes for All
  • Understand the Factors that Influence Cancer
    Outcomes
  • Improve the Quality of Cancer Care
  • Improve the Quality of Life for Cancer Patients,
    Survivors, and Their Families
  • Overcome Cancer Health Disparities

6
The Potential of Nanotechnology in Cancer
  • Nanotechnology is a disruptive technology which
    will drive a new generation of cancer diagnostic
    and therapeutic products, resulting in
    dramatically improved cancer outcomes
  • Early detection highly sensitive and specific
    sensors
  • In-vivo imaging new contrast agents,
    localization
  • Therapeutics local, on-particle delivery

The Alliance was launched
7
NCI Nanotechnology Alliance - Awards
Nanotechnology Platform for Pediatric Brain
Cancer Imaging and Therapy, University of
Washington, Seattle, Wash.
Integrated System for Cancer Biomarker Detection,
Massachusetts Institute of Technology, Cambridge,
Mass.
Novel Cancer Nanotechnology Platforms for
Photodynamic Therapy and Imaging, Roswell Park
Cancer Institute, Buffalo, N.Y. Multifunctional
Nanoparticles in Diagnosis and Therapy of
Pancreatic Cancer, State University of New York,
Buffalo, N.Y.
MIT-Harvard Center of Cancer Nanotechnology
Excellence, Cambridge, Mass.
DNA-linked Dendrimer Nanoparticle Systems for
Cancer Diagnosis and Treatment, University of
Michigan, Ann Arbor, Mich.
Detecting Cancer Early with Targeted Nano-probes
for Vascular Signatures, University of
California, San Francisco, Calif.
Nanotherapeutic Strategy for Multidrug Resistant
Tumors, Northeastern University, Boston, Mass.
Photodestruction of Ovarian Cancer ErbB3
Targeted Aptamer-Nanoparticle Conjugate,
Massachusetts General Hospital, Boston, Mass.
Nanomaterials for Cancer Diagnostics and
Therapeutics, Northwestern University, Evanston,
Ill.
Metallofullerene Nanoplatform for Imaging and
Treating Infiltrative Tumor, Virginia
Commonwealth University, Richmond, Va.
Hybrid Nanoparticles in Imaging and Therapy of
Prostate Cancer, University of Missouri,
Columbia, Mo.
Center for Cancer Nanotechnology Excellence
Focused on Therapy Response, Stanford University,
Palo Alto, Calif.
Nanosystems Biology Cancer Center, California
Institute of Technology, Pasadena, Calif.
The Siteman Center of Cancer Nanotechnology
Excellence at Washington University, St. Louis,
Mo.
Center of Nanotechnology for Treatment,
Understanding, and Monitoring of Cancer,
University of California, San Diego, Calif.
Carolina Center of Cancer Nanotechnology
Excellence, University of North Carolina, Chapel
Hill, N.C.
Near-Infrared Fluorescence Nanoparticles for
Targeted Optical ImagingUniversity of Texas M.
D. Anderson Cancer Center, Houston, Texas
Emory-Georgia Tech Nanotech-nology Center for
Personalized and Predictive Oncology, Atlanta, Ga.
Nanotechnology Platform for Targeting Solid
Tumors, The Sidney Kimmel Cancer Center, San
Diego, Calif.
145 Million/5 Years (2005-2010)
Centers of Cancer Nanotechnology Excellence
(8) Cancer Nanotechnology Platform Partnerships
(12)
8
Nanotechnology is an Enabler of New Solutions
for Cancer
Focus Areas
  • Molecular imaging and
  • early detection
  • In vivo imaging
  • Reporters of efficacy
  • Multifunctional
  • therapeutics
  • Prevention and control
  • Research enablers

Early detection Imaging Therapy
9
Differentiating the Good, the Bad, the Ugly
  • What are the nanomechanics involved in making a
    cancer cells move?

Milan Mrksich - NWU
NWU CCNE
10
The Alliance Website http//nano.cancer.gov
  • CHECK IT OUT!!!

Piotr Grodzinski, Ph.D. Program Director Email
grodzinp_at_mail.nih.gov Larry Nagahara,
Ph.D.Nanotechnology Projects Manager Email 
nagaharl_at_mail.nih.gov Jerry Lee,
Ph.D. Nanotechnology Projects Manager Email
leejerry_at_mail.nih.gov Office of the
Director National Cancer Institute31 Center
Drive MSC 2580 Rm. 10A52Bethesda, MD
20892-2580Phone (301) 496-1550 Fax     (301)
496-7807
11
NCI 2008 Budget Request Breakdown
New Grants
12
Some examples of current calls
  • The National Cancer Institute (NCI) is interested
    in
  • Early detection of the disease using imaging
  • In vitro early diagnostics multiplexed sensitive
    and specific sensors
  • Multi-functional therapeutics and localized
    therapy delivery
  • Tools and approaches to interrogate, understand,
    and manipulate single cells, structures, and
    molecules

NIH/CDC Small Business Innovation Research (SBIR)
Contract Solicitation Contract proposal receipt
date NOVEMBER 5, 2007 241 Multifunctional
Therapeutics Based on Nanotechnology 252 Nanotechn
ology Imaging and Sensing Platforms for Improved
Diagnosis of Cancer
13
(No Transcript)
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