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The Innovative Medicines Initiative

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The Innovative Medicines Initiative A winning case for Joint Technology Initiative Status In our discussion today Why Europe needs the Innovative Medicines ... – PowerPoint PPT presentation

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Title: The Innovative Medicines Initiative


1
The Innovative Medicines Initiative A winning
case for Joint Technology Initiative Status
2
In our discussion today
  • Why Europe needs the Innovative Medicines
    Initiative
  • About the Innovation Medicines Initiative
  • What we need from you

3
Creating new medicines is a high risk journey
15
Medicine
Risk assessment analysis
Gaining approval
Studies in 100-300 patients (Phase II)
10
Extensive safety studies
Studies in healthy volunteers (Phase I)
Candidate
5
Formulations developed
Early safety studies
Screening
Synthesis of compounds
years
Idea
4
Its time to re-establish our science base
before its too late
  • Over the last decade, Europes share of the
    worlds pharmaceutical research and development
    has steadily decreased

Billion euros
5
Europe is losing its scientists
  • The brain drain of researchers away from Europe
    is increasing
  • 7 out of 10 European-born US doctorate recipients
    who graduated between 1991 and 2000 had no plans
    to return to Europe
  • Source According to the European Commission 2003
    Brain Drain Study

6
Health matters to EU citizens too
Relative importance of national issues to
Europeans
in top 3 responses
Source Consensus Research (2004)
7
Its an opportunity to regain EU competitiveness
  • EU and Member States
  • Gain competitive advantage for EU, if we act fast
  • Significant economic value through small and
    large enterprises
  • More effective healthcare
  • Retain scientific talent and expand science base
  • Public and private biomedical community
  • Faster drug development process
  • A framework for academia to work in priority
    areas and establish collaborations
  • Vibrant and dynamic scientific environment

8
And most importantly
  • Patients / society
  • Faster access to innovative therapies such as
    personalised medicines
  • More knowledge-based jobs in the EU
  • More education and training available in the
    biomedical arena

9
The population in the EU is ageing rapidly
10
The elderly consume more healthcare resources
United Kingdom
20
France
Spain
Germany
15
Average expenditure per head expressed as a
share of GDP per capita ( )
Italy
10
5
0
Age groups
Source Economic Policy Committee (2001)
Budgetary challenges posed by ageing populations
11
New medicines bring value to patients, health
care systems and society
  • Mortality rates in Europe have declined by almost
    40 over the last 30 years, thanks in part, to
    new medicines (EU Health Report)
  • Spending on prescription medicines translates
    into overall cost savings for healthcare systems
    and society. When medicines are used to treat an
    illness, more expensive care such as surgery
    and hospital stays and lost school or work days
    can often be avoided or decreased

12
Its about people living longer, healthier and
more productive lives
13
In our discussion today
  • Why Europe needs the Innovative Medicines
    Initiative
  • About the Innovation Medicines Initiative
  • What we need from you

14
Science and technology advances
presentsignificant opportunities
Better understanding of disease/drug mechanisms
omics

Better medicines, faster
Imaging
Health benefits for EU citizens
IT
15
It aims to improve the way new medicines are
discovered for the benefit of patients
  • Key RD bottlenecks to overcome
  • Safety Making medicines safer
  • Efficacy Making Medicines more effective
  • - Often disease specific, initial
    focus on
  • 5 disease areas with high scientific
    challenges
  • Cancer Brain disorders Inflammatory
    diseases, Diabetes and
  • Infectious diseases
  • 3. Knowledge Management Using new technologies
    to manage and organise data to create knowledge
    so scientists can predict benefit and risk of new
    therapies
  • 4. Education and Training Addressing expertise
    gaps in Europe

16
Our approach has already proven to work
Pilot project FP6 successfully completed
  • 16 Companies 14 Universities 7 SMEs from
    across EU
  • 18 mio euros including European Commission
    funding
  • Biomarkers in Alzheimers Disease
  • Better and earlier diagnosis of onset of disease
  • Predictive Toxicology
  • New approaches to measure earlier potential
    medicine side effects

17
Recognised and supported by a wide community
All Patient Associations consulted are very
positive
UK enthusiastically supports the IMIs priorities
and goals
Mirror National Initiative are mushrooming in
Spain, Nordic countries, Poland, etc
France INSERM and its academic partners are
strongly supportive
18
Industry will not be funded by the EC
50
50
IMI to be funded equally by pharma industry and
European Commission
100
100
Research performed by public organisations funded
by EC
  • Research performed by industry funded by industry

19
IMI - A compelling case for JTI Status
  • Innovation and development of science base is
    crucial to Europe
  • Health is high on the political agenda with our
    ageing population
  • Pharmaceutical innovation brings benefits to
    peoples health and wealth to society
  • Focused on creating the environment which will
    enable important new medicines get to patients
    faster
  • IMI has a clear focus on outcomes, an agreed and
    proven collaborative approach, and is ready to
    start implementation
  • Commitment of industry to contribute 100 of own
    costs

20
In our discussion today
  • Why Europe needs the Innovative Medicines
    Initiative
  • About the Innovation Medicines Initiative
  • What we need from you

21
How you can help to create a healthier and more
competitive EU
  • We would like to count on your help in
  • Spreading the voice about IMI
  • Keeping an eye on 7th FP calls
  • Creating a strong collaboration between public
    and private entities

Creating biomedical RD leadership for Europe
to benefit patients and society
22
The ultimate beneficiaries ...
People living longer, healthier and more
prosperous lives in the EU
23
For further information
  • http//europa.eu.int/comm/research/imi.html
  • defraja_at_altaweb.eu
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