Genetic Mutations

1
Genetic Mutations

• Objectives
• 8.4 Relating ways chance, mutagens, and genetic
  engineering increase diversityExamples
  insertion, deletion, translocation, inversion,
  recombinant DNA

2
Insertions

• Can be three types
• Point mutation
• Frame-shift mutation
• Insertion
• Point mutation a change in a single base of the
  gene sequence.
• The fat cat ate the wee rat.
• The fat hat ate the wee rat.

Source http//www.daftblogger.com/genetic-disease
s-and-mutations/frameshift-mutation/
3
Insertions

• Frame shift mutation one or more bases are
  inserted or deleted, shifting the other bases,
  sometimes into nonsense.
• The fat cat ate the wee rat.
• The fat caa tet hew eer at.

Source http//www.daftblogger.com/genetic-disease
s-and-mutations/frameshift-mutation/
4
Insertions

• Insertion the addition of extra DNA (CAN result
  in frame-shift mutations)
• The fat cat ate the wee rat.
• The fat cat xlw ate the wee rat.

Source http//en.wikibooks.org/wiki/Structural_Bi
ochemistry/DNA_Mutation
5
Deletions

• A portion of DNA is deleted from a chromosome.
• Can range from no effect to death.
• This is the cause of 2/3 of case of Duchenne
  muscular dystrophy.

Source http//en.wikibooks.org/wiki/Structural_Bi
ochemistry/DNA_Mutation
6
Translocation

• A transfer of genetic information between 2
  nonhomologous chromosomes.

Source http//employees.csbsju.edu/HJAKUBOWSKI/cl
asses/ch331/dna/mutation2.gif ... utechdmd2015.wik
ispaces.com
7
Inversion

• An entire section of DNA is reversed.
• The fat cat ate the wee rat.
• The fat tar eew eht ets tac.

Source http//employees.csbsju.edu/HJAKUBOWSKI/cl
asses/ch331/dna/mutation2.gif ... utechdmd2015.wik
ispaces.com
8
Summary
Source http//msthomas79.edublogs.org/2010/04/15/
rna-protein-synthesis-mutations-in-a-nutshell/
9
Insertion and Deletion Results
Source http//www.ucl.ac.uk/sjjgsca/DNAmutation.
html
10
What Do Chromosomes REALLY Look Like?