???(Lyme Disease)?????????,???????????????????,???????????????????????????????????????

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• ???(Lyme Disease)?????????,???????????????????,???
  ????????????????????????????????????
• ????????????,????

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• 2003???SARS??? ?????????
• ????????O157?H7???0139??(???????)?????????????????
  ??????????????????????????????????????????????????
  ????????????????????????

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???

• ?????
• (Borrelia burgdorferi,???????Bb)
• ??????,?????
• ???? ?????????????,
• ?10-40um,???????,
• ??,????

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• ???,??????
• ???,41KD??????????????????
• ??????????????,???????????2-4?
• ?????????????,????????????????

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• ????-???
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• 1???????
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• 2.???????
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????,20???
??????,6??10??? 6????
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• ???? ?????????????????????????????

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?????
????,????,????????? ??????????? 11 ???????
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• ??CDC???????????????????,??????45???
•  1991?,????????1???
• 2003??2005??,?????????,??6.4???????????5??14??????
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• 2005???????????????????20????????,????????????5.33
  ,13????????????????????
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• ???????????????1????????????????????????????????
  300????,????????23?,?10????????,??????217??
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• 2004??2?26?,?????????????????,?????????CDC??????
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????????

• ??22??????????????5.61
• ????????????10.7(121/1201),????6.74(81/120)
• ???????????10.78
• ????????????10.25

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2?????????? 3?????IL-1 4?????HLA-DR2?3?4
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• 332d,??9d
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• 3?(?????)

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????

• 1?(????? erythema chronicum
• migrans,ECM)
• ?????????,???????
• ??????
• ??????????,??????,
• ??????????????
• ?5-50cm,?????
• ?????????????

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???(?????)
1???????
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2?(?????)

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???(?????)
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3?(?????)

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????? ?? WBC???,ESR? ????? ????????????????????
Bb(??????,??) Bb-DNA ????? ???IgM,IgG
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6????
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?????

• ??EM?????????????
• ????????10-30?
• ????????????14-21?
• ???????????14-21?,?
• ????30?,2000???/?

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??? 1??????????? 2???????????????????
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4?????????????????????? 5?????????????????????
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summary

• Lyme disease is caused by Borrelia burgdorferi
• Source of infection of the disease is mouse, and
  transmitted by tick bitting.
• Clinical manifestation characteristized by skin ,
  heart, nerves and joint damage.
• Skin damage represents as erythema chronicum
  migrans