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High-Throughput Microscopy and Computational/Theoretical Challenges in the Analysis of Neural Circuit Structure

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High-Throughput Microscopy and Computational/Theoretical Challenges in the Analysis of Neural Circuit Structure Society for Neuroscience 2008 Minisymposium – PowerPoint PPT presentation

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Title: High-Throughput Microscopy and Computational/Theoretical Challenges in the Analysis of Neural Circuit Structure


1
High-Throughput Microscopy and Computational/Theor
etical Challenges in the Analysis of Neural
Circuit Structure
Society for Neuroscience 2008 Minisymposium Tuesda
y, November 18, 2008 Room 207B
2
The goal of neural science is to understand the
mind, how we perceive, move, think and remember.
  • Eric Kandel, James Schwartz, Thomas Jessell,
  • Principles of Neural Science, 4th Ed.

3
  • Santiago Ramón y Cajal
  • Considered a founder of Neuroscience
  • Used Golgi staining to study the structure
  • of the central nervous system

Sotelo, C. Nature Reviews Neuroscience 4, 7-77,
2003
4
We know a great deal about how neurons
communicate at the level of the individual cell
and synapse

http//morbidanatomy.blogspot.com/2008/0/santiago-
ramn-y-cajal-1852-934.html
http//www.learner.org/courses/biology/ units/ne
uro/images.html
5
Kandel et al., Principles of Neural Science, 4th
Ed.
Cholinergic synaptic vesicle
6
We know much less about what happens at the
network level
Sotelo, C. Nature Reviews Neuroscience 4, 7-77,
2003
http//www.learner.org/courses/biology/
units/neuro/images.html
7
http//www.learner.org/courses/biology/
units/neuro/images.html
http//www.mbl.org/atlas170/atlas


170_start.html
8
This minisymposium will survey the latest
advances in high-throughput microscopy methods
with the goal of advancing our understanding of
brain networks. Imaging and analysis of neuronal
microcircuits on the scale of whole small animal
brains will be presented. Pertinent
computational issues will be discussed.
9
Speakers
  • Louise C. Abbott, Texas AM University
  • Knife-edge scanning microscope (KESM)
  • Kristina D. Micheva, Stanford University
  • Array tomography to probe molecular architecture
    of neural circuits
  • Kenneth Hayworth, University of Southern
    California
  • Use of SEM imaging to create ultrathin section
    libraries
  • Randal A. Koene, Boston University
  • NETMORPH and automated network reconstruction
  • Ravi Rao, IBM TJ Watson Research Center, NY
  • High-performance computing techniques for
    neuro-image analysis
  • Yoonsuck Choe, Texas AM University
  • Fast algorithms for reconstructing cortical
    neural circuits

10
SPEAKERS
Louise C. Abbott, Texas AM University Knife-edge
scanning microscope (KESM) Kristina D. Micheva,
Stanford University Array tomography to probe
molecular architecture of neural
circuits Kenneth Hayworth, University of Southern
California Use of SEM imaging to create
ultrathin section libraries Randal A. Koene,
Boston University NETMORPH and automated network
reconstruction Ravi Rao, IBM TJ Watson Research
Center, NY High-performance computing techniques
for neuro- image analysis Yoonsuck Choe, Texas
AM University Fast algorithms for
reconstructing cortical neural circuits
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