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Biological Oxidation

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Biological Oxidation * * CO2 H2O ... – PowerPoint PPT presentation

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Title: Biological Oxidation


1
? ? ?
  • ? ? ? ?
  • Biological Oxidation

2
? ?
????????????????,????????????????????????,????CO2
? H2O?????????????CO2,????????,???????(cellular
respiration)?
3
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4
????????????
  • ????
  • ????????(CO2,H2O)??????

5
  • ??????????????
  • ???????????
  • ?????????ATP??
  • ????????
  • ??????????H2O
  • ???????CO2

????
6
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7
??? ??ATP?????The Oxidation System of ATP
Producing

8
??ATP
  • ?????
  • ??????????21KJ/mol?????,???? ?P?
  • ???????

9
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10
???????
??????????? ?????????
11
ATP??????
ATP
???(????) ???(??????) ???(????) ??(???) ??(????)
ADP
??????????????ATP????
12
???????
(oxidative phosphorylation)
??????????????ADP???,??ATP,?????????
???????? (substrate level phosphorylation)
?????????????,?????,?ADP?????ATP????
13
(?)???
  • ??
  • ???????????(2H)????????????????????,?????????,????
    ?????????(respiratory chain),???????(electron
    transfer chain)?
  • 2H ? 2H 2e

14
1? ? ? ? ? ? ?
15
???????????????(complex)
?? ? Cyt c ?????????????
16
?????????????????
17
???
??? ??
???
18
???? NADH-?????
  • ?? ????NADH????? (ubiquinone)

19
??(??Q, CoQ, Q)
20
???????
21
???? ???-?????
  • ?? ????????????

22
? ? ? ?
?????????????????????????,??????????????
23
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25
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26
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27
2???????????
??????? ? ???????? ?
????? ? ??????? ? ???????????
28
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29
NADH?????
FADH2?????
30
? NADH????? NADH ??????Q ??????Cyt c
??????O2 ? ???????? ??? ????? ?Q ??????Cyt c
??????O2
31
?????
32
(?)?????????
33
??????????
?????????
34
(?) ??????????
  • 1. ??????(chemiosmotic hypothesis)
  • ?????????,????(H)?????????????????,??????????????
    ????????????????ADP?Pi??ATP?

35
??????
36
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37
2. ATP??
ATP???????
38
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39
?H??????F0?a???c???????,???????,3?ß??????????
ATP???????
40
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41
(?)??????????
1. ???
? ?????? ? ???? ? ????????
42
?????????????
43
?????????????????
44
?????????(?????????)
45
  • ???(oligomycin)
  • ?????F0??????,??ATP??

???
ATP???????
46
(?)ADP????? (?)????? Na,KATP??????????????? (?
)???DNA?? ????DNA??????
47
???????? ???????
?µH ?????????Hm?????HHc ?????H
48
??????????????
49
(?) ???NADH???
  • ????
  • a-??????
  • (a-glycerophosphate shuttle)
  • ???-??????
  • (malate-asparate shuttle)

50
1. a-????????
51
2. ???-????????
52
(?)???????
(adenine nucleotide transporter)
??ADP?ATP ????
53
(?)???????????
??????? ? ??????????? ? ???????? ?
?????????????????????? ? ??????? ? ??????
54
  • ??? ??????
  • The Others Oxidation Enzyme Systems

55
???????????
56
????????????
(?)?????(catalase) ????,????4????
57
(?)?????(perioxidase) ???????,??H2O2????????????

58
?????????
???? ????(O2?)?H2O2?????(OH)????
SOD
2O2? 2H
H2O2 O2
?????
H2O O2
SOD??????? (superoxide dismutase)
59
?????????
3. ????????????
H2O2 (ROOH)
NADP
2G SH
???????
H2O (ROHH2O)
NADPHH
G S S G
??????????????????
60
?????????
(?)????(monoxygenase)
?????
RH NADPH H O2
ROH NADP H2O
??????????(mixed-function oxidase) ????(hydroxylas
e)?
??????????P450 (Cyt P450)???
61
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62
(?)????
?????????2?????????????2??????
? ?
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