Title: Human Genome Browser
1???-??????????????? ???? ?????? ? ????????
????????
- ??? ????? ???-??????????????? ???? ???????
- ????? ??????? ??????? ????? ??
- ??????? ?????-??????????????? ??? ?????? ?
???????? ???????? - Human Genome Browser
2??? ????? ???-??????????????? ???? ???????
- ??????? ???????????? ??? (? ??
????????????????? ??????????????????) - ???????? ???????? ??????????? ?? ???????????
????, ? ?? ???????????????????, ??????????? ??
??????? ??????????? ???? ??????????? ??? ?????
????? ? ?????? ????? ?? ???
3?????? ?????? Gene Entrez (?????? LocusLink) ?
NCBI
- ??????? ???????????? ????? ?????????? ?????
?? ?????????, ?????????? ?????? ????? ?/???
??????????????? ??????? ????
4DUT ??? ????????
5??????????? ??????
- Bibliography
- Related Articles in PubMed
- GeneRIFs Gene References Into Function
- Interactions
- General gene information
- Markers
- Genotypes
- Pathways
- Homology
- GeneOntology
- General protein information (Names, ECs, ACs)
- NCBI Reference Sequences (RefSeq)
- mRNAs and proteins
- Reference assembly Alternate assembly Genomic
- Related Sequences (links between ACs of different
types) - Additional Links (OMIM, PharmGKB, HRDP, UniGene)
6MapViewer
7???????? ???? ??????
- ?????? ?????? ?????
- ??????????? ???????????? ??????? ??? ???? ??????
?????? - ????????? ???? ? ?????? ????? ???????
????????????? ???????? (comparative genomics) - ?????????? ???? ????????? ?????????? ? ??????
?????? - ???????? ?????????? ? ?????, ?? ? ????????
????????? - ???????? ???????? ??????????? ?????????????
???? ??????????????? ?????????? - NCBI -gt Genomic Biology (http//www.ncbi.nlm.nih.g
ov/Genomes/)
8???????? ??????
??? ???????? ????? (?????? ???????? ?????? ???
?????? ??????? ?????? ??????????)
http//www.ncbi.nlm.nih.gov/genomes/VIRUSES/viruse
s.html
9HIV2 ?????
10Sequence Viewer
11Protein coding genes link
12gMap (comparative genomics)
- Zoom in, zoom-out
- ??????? ???????????? ???????
- ??? ???????
- (!) ??????????? ????? ? ?????? ???? ????!
13????????????? ?????? ?? ????? NCBI
Tools legend T - TaxMap P - ProtTable C - COG
Table D - 3-D neighbors L - BLAST S - CDD
search G - GenePlot X - TaxPlot M - gMap F -
FTP R - Publications
14COG Table
15COG Table ?????? (Overview)
16TaxMap
- ?????? ????? ???
- ????????? ????? ???????, ????? ????
- ???? ????????????? ??????? ??????? BLAST-????
- ?????? ???? ????????????? ??????
- ????????????? ???? ????? ????? ?????? ?????????
- Click ?? ????? ?????? ????? ????? ? ????????
17Genomes in progress
18TIGR Comprehensive Microbial Resources
http//cmr.tigr.org/tigr-scripts/CMR/CmrHomePage.c
gi
????????? ?? ???????????, ? ?? ?? ??????
19??? ?????? ?? TIGR
20?????????
- NCBI Map Viewer, FTP ??? ??????
??????????????????, ??????????????? ??????,
?????? ?? ?????????????????? ???? ?????? - MapViewer ??????? LocusLink
21Human
- ??? ???????? ????????
- Ensembl (http//www.ensembl.org) EBI Sanger
Institute, ?????????? ???? IDs, 35
??????????????? ????? - Human Genome Browser (http//genome.ucsc.edu
/) UCSC, USA - ?????????? GenBank IDs, 41 ??????????????? ???
22Ensembl
Ensembl Tutorials and Worked Examples
http//www.ensembl.org/info/helpdesk/tutorials/in
dex.html
23Human Genome Browser
RefSeq ID Chr Band Gene name Coords
24DUT gene (dUTPAse)
25?????? RefSeq ?????
26Provided tracks (types)
27Custom Track
- ??????????? ??????????????? ???? ???????????
????????? ????? ??????????? ?????-???? ?????
??????? - Upload ? BED, GFF, GTF, WIG ??? PSL ???????
- ????.,
- chr1 15003 19498 name1 1
- chr1 58954 59871 name2 1
- chr1 321669 332669 name3 1 -
28??? ??? ?????????
29BLAT
- BLAT BLAST ? ???????????, ????????????????? ??
????? ??????????? ???????????????-???? ? ??????
??????
30Table Browser