The Science and Ethics of Stem Cell Research - PowerPoint PPT Presentation

Loading...

PPT – The Science and Ethics of Stem Cell Research PowerPoint presentation | free to download - id: 4e5c95-NWQxM



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

The Science and Ethics of Stem Cell Research

Description:

LIVE INTERACTIVE LEARNING _at_ YOUR DESKTOP The Science and Ethics of Stem Cell Research Presented by Jeanne Ting Chowning, MS Northwest Association for Biomedical Research – PowerPoint PPT presentation

Number of Views:243
Avg rating:3.0/5.0
Slides: 71
Provided by: Office2004966
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: The Science and Ethics of Stem Cell Research


1
LIVE INTERACTIVE LEARNING _at_ YOUR DESKTOP
The Science and Ethics of Stem Cell
Research Presented by Jeanne Ting Chowning,
MS Northwest Association for Biomedical Research
Thursday, May 26, 2011
2
The Science and Ethics of Stem Cell
Research Grades 9 -12 Northwest Association for
Biomedical Research www.nwabr.org
3
Todays Web Seminar
  • Background
  • Lessons and Activities
  • Sample Activities
  • Assessment
  • Q and A

4
The Curriculum
  • 1 Lab Investigation
  • 5 Lessons
  • 2 Assessment Options

5
Background
  • Overview
  • National Science Ed Standards
  • Essential Questions/Enduring Understandings
  • Unit Objectives
  • Lesson Materials
  • Teaching sequence for each day
  • Masters
  • Appendix
  • Teacher support materials

6
Good ethics begins with good science and good
facts. -Ken Ryan
7
Stem Cells - Defining Properties
  • 1.  Stem cells are unspecialized 2.  They have
    the ability to self-renew 3.  They can change
    into mature cell types .

8
Plenty of Planaria Laboratory Investigation
9
Fresh water Flatworms Free living
Carnivores Avoid Light Sexual or Asexual
10
Regenerative Ability
  • Morgan 1/279 of a planaria can regenerate a
    whole organism
  • Recent studies show that one neoblast cell is
    enough!

11
Neoblasts
  • Planarian Stem Cell
  • 30 of cells in worm are neoblasts

12
Planaria are complex
Excretory/ Osmoregulatory System
Nervous System
13
Lab Activity
  • Student groups receive 3 planaria
  • Whole class studies one horizontal cut (pooled
    data)
  • Each group determines its own cuts
  • Each group has a control
  • Many inquiry opportunities

14
http//planaria.neuro.utah.edu/movies/stemcellmovi
e.html http//www.hhmi.org/biointeractive/stemcell
s/planarian_regen.html
15
Lets pause for questions. Does anyone have a
question about using planaria?
16
Lesson 1 Stem Cell Development
17
Human Embryonic Stem Cells
Where on this chart you think hESC come from ?
8wks embryonic development
Blastocyst embryo at day 5 0.2mm in size
18
Zygote
19
Morula
20
Morula 16 cells
Source Florida Institute for Reproductive
Science and Technologies
21
Blastula/Blastocyst
22
Blastula Pre-Implantation (3-14 days)
Courtesy RWJMS IVF Program
23
(No Transcript)
24
Early Embryonic Development
http//www.nationalgeographic.com/ngm/
25
Gastrula
26
Fate Decisions
Fertilized egg
Multipotent
27
Blood Cell Lineages
http//en.wikipedia.org/wiki/FileHematopoiesis_si
mple.svg
28
Lets pause for questions. Does anyone have a
question about the embryonic development activity?
29
Lesson 2 Techniques for Obtaining Stem Cells
30
  • Techniques to obtain stem cells
  • Which is the source of human embryonic stem cell
    lines?
  • In vitro Fertilization
  • Therapeutic Cloning (Somatic Cell Nuclear
    Transfer)
  • Umbilical Cord Blood and Bone Marrow
  • Induced Pluripotent (iPS) cells

31
Techniques Graphic Description
Story
32
http//en.wikipedia.org/wiki/FileHuman_embryonic_
stem_cell_colony_phase.jpg
33
iPS cells
34
Potential Uses
35
(No Transcript)
36
http//en.wikipedia.org/wiki/FileStem_cell_treatm
ents.svg
37
Stem Cell Resources
  • http//learn.genetics.utah.edu/content/tech/stemce
    lls/
  • http//www.stemcellresources.org/index.html
  • http//stemcells.nih.gov/

38
Lesson 3 Case Study One Familys Dilemma
39
It also helps people decide how to behave and
treat one another, and what kind of communities
would be good to live in.
Ethics definition

Ethics seeks to determine what a person should
do, or the best course of action, and provides
reasons why.
40
Introducing Bioethical Principles through
Student Skits
41
Parent respecting childs career choice Parent
NOT respecting childs career choice Parent
helping child with homework Parent NOT helping
child with homework Parent being fair between
siblings Parent NOT being fair between siblings
42
Respect for Persons
Recognizing that all humans have moral standing
and acting in a way that honors that moral
standing
Supporting, and not interfering with, peoples
ability to make choices for themselves.
43
Harms and Benefits
.
Minimizing harms while maximizing benefits
Acting to lesson negative outcomes and promote
positive ones.
44
Fairness
Sharing benefits, resources, risks, and costs
equitably.
45
Case Study One Familys Dilemma
  • Couple from religious background
  • Trouble conceiving naturally
  • Had 2 children by IVF
  • Had 6 blastocysts remaining, which were frozen
    in storage
  • Insurance no longer covers storage
  • Researchers would like to use
  • Cook, Gareth, After 2 Children Via IVF, Pair
    Faced Stem Cell Issue The Boston Globe, April 4,
    2004.

46
What are some possible options?
  • Option 1

  • Option 2

  • Option 3


Raise your hand to volunteer!
47
Case Study One Familys Dilemma
  • Continue to pay
  • Donate embryos to research
  • Donate embryos to other infertile couples
  • Discard the embryos
  • Use embryos to have more children

48
What are the relevant ethical considerations?
  • Value diverse positions but also guide students
    towards shared ethical considerations
  • Respect for persons
  • Minimizing Harms and Maximizing Benefits
  • Fairness
  • Others

49
Which ethical principle is given priority if they
donate the embryos to research?
  • Respect for Persons

  • Minimize Harms/Maximize Benefits

  • Justice


Raise your hand to volunteer!
50
Which ethical principle is given priority if they
decide to discard the embryos?
  • Respect for Persons

  • Minimize Harms/Maximize Benefits

  • Justice


Raise your hand to volunteer!
51
Science cannot resolve moral conflicts, but it
can help to more accurately frame the debates
about those conflicts.
Heinz Pagels
52
Lets pause two minutes for questions
53
Lesson 4 Shades of Gray
54
Who or what will be affected by the outcome?
Stakeholders have a stake in how the question
is resolved Can be individuals, groups,
institutions Provides students with the
opportunity to be in someone elses shoes
55
Everyone Raise Your Hand (Leave your hand up to
determine order!)
  • Read the stakeholder biography according to the
    following chart.
  • If you are number 1-5 read stakeholder 1
  • If you are number 6-10 read stakeholder 2
  • If you are number 11-15 read stakeholder 3
  • If you are number 16-20 read stakeholder 4
  • If you are number 21-25 read stakeholder 5
  • If you are number 26-30 read stakeholder 6
  • If greater than 30, join according to your ones
    place number 31 group stakehold 1

56
Does your stakeholder agree?
  • It is ethically acceptable to conduct research
    using human embryonic stem cells.

Strongly Disagree
Strongly Agree
Disagree
Agree
57
Small Group Breakout
  • Introduce the stakeholder you represent.
  • State why you placed your stakeholder where you
    did.

58
Actual Positions
  • Were you surprised by your stakeholders
    position?
  • v YES X NO

59
Lets pause two minutes for questions
60
Lesson 5 Ethics and Policy
61
Socratic Seminar
62
Final Assessment Option 1 Individual A Letter
to the Presidents Commission for the Study of
Bioethical Issues Option 2 Group A Grant
Application
63
  • Science
  • Ethical Principles
  • Stakeholders
  • Decision-Making Model
  • Better-reasoned Arguments

64
Thank You!
Funding provided by Collaborations to Understand
Research and Ethics, (CURE) Science Education
Partnership Award, National Institutes of Health
65
Photo credits
  • Istockphoto
  • Cell Imaging Core, Center for Reproductive
    Sciences
  • Northwest Association for Biomedical Research
  • RWJMS IVF Program
  • SciencePhotoLibrary
  • Wellcome Trust Image Library
  • Wikimedia Commons

66
How can you receive a copy of this free
curriculum?
  • Review and request from NWABR
  • www.nwabr.org
  • Other curricular materials include Bioethics 101,
    Animals in Research, HIV Research, Ethics Primer,
    Bioinformatics/Genetic Testing,
    Bioinformatics/Genetic Research

67
Thank you to the sponsor of tonight's Web Seminar
This web seminar contains information about
programs, products, and services offered by third
parties, as well as links to third-party
websites. The presence of a listing or such
information does not constitute an endorsement by
NSTA of a particular company or organization, or
its programs, products, or services.
68
http//learningcenter.nsta.org
69
http//www.elluminate.com
70
National Science Teachers Association Dr. Francis
Q. Eberle, Executive Director Zipporah Miller,
Associate Executive Director Conferences and
Programs Al Byers, Assistant Executive Director
e-Learning
NSTA Web Seminars Paul Tingler, Director Jeff
Layman, Technical Coordinator
LIVE INTERACTIVE LEARNING _at_ YOUR DESKTOP
About PowerShow.com