Basic Genetic Mechanisms

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• Introduction
• Basic Genetic Mechanisms
• Eukaryotic Gene Regulation
• The Human Genome Project
• Test 1
• Genome I - Genes
• Genome II Repetitive DNA
• Genome III - Variation
• Test 2
• Monogenic and Complex Diseases
• Finding Disease Genes
• Pharmacogenomics
• Test 3
• Your Presentations
• Your Presentations
• Happy New Year! ?

http//priede.bf.lu.lv/ Studiju materiali /
MolekularasBiologijas / MolGen / EN
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Classes of tandem repeats

• Satellites 5 - 171 bp unit large clusters (gt
  100 000 bp)
• heterochromatin regions of centromeres not
  transcribed
• function not known likely the formation of
  centromeres (a satellite)
• Minisatellites 6 - 64 bp unit medium-size
  clusters (100 - 20 000 bp)
• heterochromatin regions of telomeres or their
  vicinity not transcribed
• telomere repeats the structure and replication
  of chromosomes
• Microsatellites 1 - 4 bp unit short clusters
  (lt150 bp )
• scattered along the genome no known function
  widely used as markers
• if located within or nearby a gene can cause
  triplet expansion dieseases

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