Dr. Janice Swab, a world-traveling evolutionary biologist will be speaking!

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WALKER BIOLOGY CLUB MEETING GUEST SPEAKER!!

• Dr. Janice Swab, a world-traveling evolutionary
  biologist will be speaking!
• Come hear about Following Darwin and not
  following Darwin in the Southern Hemisphere!
• January 23, 2008
• 500 p.m. in Room 210

Pizza Drinks Provided!
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Campbell Pre-Med Allied Health
Were here to help
Welcome Back! Come join us for our first meeting
of the semester! Thursday, Jan 24 _at_ 500PM
Science Bldg. Room 210 Everyone is Welcome!
 
CampbellPreMed_at_gmail.com
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Announcements

• Begin literature search!
• Locate a minimum of 1 review article 2 peer
  reviewed research articles.
• Type out a reference list have a copy of the
  papers turned in by Feb 4!
• Worth a 10 pt quiz grade.
• Exam 1 Mon, Jan 28
• Chapter 1

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Antigen Presentation to T- cells

• continued

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alpha
alpha
beta
B-2 microglobulin

• Antigen must be processed to be displayed on MHC.

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The Endogenous Pathway

• MHC class I
• Endogenous Ag
• derived from pathogens that multiply
  intracellularly.

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Exogenous Pathway

• MHC class II
• Exogenous antigen
• derived from pathogens that multiply outside of
  host cells or inside the phagolysosome.

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How are T cells Activated?
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T cells engage cells carrying the MHC with
antigen.

• TCR on CD4 T cells engages APC with MHC class II
  molecules.
• TCR on CD8 T cells engages cells with MHC class
  I molecules.

Immunology (kuby)
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For successful T cell engagement of the APC

• TCR must recognize bind to the MHC.
• CD4 or CD8 must participate.
• TCR must recognize bind to the antigenic
  peptide.

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• The TCR on the CD4 T cell engages the MHC class
  II molecule on APC! (Fig. 1.27 p. 25).

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• The TCR on CD8 T cells interact with the MHC
  class I molecule Ag.

Toxic granules released
Virally infected CHO cells.
Fig. 1.26, p. 24
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What does the interaction of T cells with the APC
accomplish?

• Clonal selection of the T cell leads to
• Proliferation
• Differentiation into effecter cells
• TH cells
• TC cells
• Differentiation into Memory cells

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Why do T cells need to undergo positive
negative Selection to achieve tolerance?
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The Humoral Immune Response

• Activation of B cells

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1. T Independent Antigens

• Polysaccharides LPS.
• Crosslinks multiple Ig receptors.

Fig. 16-14, nester Microbiology
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2. T dependent antigens

• Costimulation by the interaction with Th2 cells
  is required!

A strong B cell Response generally requires
cytokine production from the Th2 cells.
Fig. 1.21, Janeway (6th ed)
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Clonal selection clonal expansion
Generally require Th2 cell assistance
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What are the activities of Antibody?
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• Antibody Dependent Cell mediated Cytotoxicity
  (ADCC)
• NK cells (natural killer cells)-
• FcR (Fc receptors).
• Kills
• tumor cells
• Pathogens
• cells infected with pathogens.

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Antibody Function
Fig. 1.29, 2nd ed
Immune Complex formation
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• Ab can initiate complement activation by the
  classical pathway.

• http//www.bmb.psu.edu/courses/bisci004a/immune/ac
  tivate.jpg

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Overview of the two arms of adaptive immunity

• Humoral Immunity Cell Mediated Immunity.

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B cell internalizes Ag now is an APC

• Fig. 1.7, Immunology (kuby) 4th ed

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• Fig. 1.13, p. 13, Immunology (kuby) 4th ed

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Adaptive Immunity Demonstrates Primary
Secondary Responses
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Adaptive Immunity- Primary Secondary Responses
p. 28, Parham
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T cells demonstrate primary secondary responses

• Mouse A receives skin grafts

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Improper immune responses may lead to allergies
or autoimmune disease.
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• Coxsackie viruses

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