August 10, 2005 - PowerPoint PPT Presentation

Loading...

PPT – August 10, 2005 PowerPoint presentation | free to download - id: 44d80c-ODBmY



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

August 10, 2005

Description:

3 enzymes of glycogen breakdown (Glycogenolysis) glycogen phosphorylase glycogen debranching enzyme phosphoglucomutase 3 enzymes of glycogen breakdown ... – PowerPoint PPT presentation

Number of Views:28
Avg rating:3.0/5.0
Slides: 48
Provided by: immoesc
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: August 10, 2005


1
Lecture 5
  • August 10, 2005

Lehninger Chapter 14 (4th ed.) complete
sections 14.2 and 14.3 skip section 14.4 for
now
Lehninger Chapter 15 (4th ed.)
METABOLISM OF GLYCOGEN
2
Enzymes required for galactose metabolism
kinase
Galactose Galactose 1-P
UDP-Glu
ATP ADP
Uridyl transferase
epimerase
UDP-Gal
Glucose 1-P
phosphoglucomutase
Glucose 6-P
3
(No Transcript)
4
seen by electron microscopy
Figure 7-14b
5
3 enzymes of glycogen breakdown(Glycogenolysis)
  1. glycogen phosphorylase
  2. glycogen debranching enzyme
  3. phosphoglucomutase

6
Non-reducing end
Reducing end
Figure 7-11
7
Can reduce Cu2
Oxidized sugar
Cannot reduce Cu2
Figure 7-10
Note this shows the ß, not a configuration
8
OH
Figure 15-3
9
Pyridoxal phosphate cofactor
1
2
3
4
1
2
3
4
Figure 15-4
10
Pyridoxal phosphate cofactor
Figure 15-3
11
3 enzymes of glycogen breakdown(Glycogenolysis)
  1. glycogen phosphorylase
  2. glycogen debranching enzyme oligo (a1?6) to
    (a1?4) glucantransferase
  3. phosphoglucomutase

12
Figure 7-15b
13
1
2
3
4
1
2
3
4
1
1
2
3
4
2
3
4
Figure 15-4
14
Hydrolysis, NOT Phosphorolysis
Figure 15-4
15
3 enzymes of glycogen breakdown(Glycogenolysis)
  • glycogen phosphorylase
  • glycogen debranching enzyme
  • Phosphoglucomutase
  • Glu-1-P ? Glu-6-P

16
Glu 1-P ? Glu 6-P phosphoglucomutase
Figure 15-5
17
LNC 15.13
18
GLYCOGEN METABOLISM
GLYCOGEN SYNTHESIS
LNC Chapter 15 (Section 1)
19
UDP glucose is the activated precursor
p. 565
20
Glu ATP ? Glu-6-P ADP
  • Enzymes
  • hexokinase I and
  • hexokinase II in muscle,
  • hexokinase IV (glucokinase) in liver

21
Glu-6-P ? Glu-1-P
  • Phosphoglucomutase

22
Glu-1-P UTP ? UDP-Glu PPi
Glu-1-P
UDP-Glu
Figure 15-7
23
Start with glycogenin, a primer and
enzyme. Muscle form and Liver form
(glycogenin-2)

Figure 15-10
UDP-glucose
24
Figure 15-11a
25
LNC (3rd ed) 20-14 (not found in 4th edition)
26
Figure 15-8
27
Figure 15-9
28
Figure 15-11b
29
(No Transcript)
30
CONTROL OF GLYCOGEN SYNTHESIS AND BREAKDOWN
31
Fig 15-13
32
GLYCOGEN UDP-Glu
Glu-1P Glu-6P Fru-6P Fru-1,6 bis
P DHAP GAP
phosphorylase
synthase
Fructose-1,6-bis phosphatase
Phosphofructokinase (PFK-1)
33
Fig 15-14
34
Covalent modifications
Ligand-induced conformational changes
35
Fig 15-24
36
Fig 15-26
37
(No Transcript)
38
adenyl cyclase
ATP
cAMP
phosphodiesterase
ADP
AMP
39
guanyl cyclase
GTP
cGMP
phosphodiesterase
40
LNC 12-15
41
(No Transcript)
42
Fig 15-25
43
Fig 15-27
44
Fig 15-29
45
Adenylate kinase
2 ADP
ATP
AMP

K 0.44
46
(No Transcript)
47
(No Transcript)
About PowerShow.com