Title: FUTURE HIV RESEARCH EFFORTS PLANNED FOR THE CLINICAL TRIALS NETWORK
1FUTURE HIV RESEARCH EFFORTS PLANNED FOR THE
CLINICAL TRIALS NETWORK
- James L. Sorensen, Ph.D.
- Susan Tross, Ph.D.
- Raul Mandler, M.D.
- University of California, San Francisco
- and San Francisco General Hospital
- Presentation at American Psychological
Association, San Francisco, CA - August 2007
2PREVIEW
- Importance of HIV/AIDS in CTN efforts
- Mechanisms for addressing HIV/AIDS in CTN
- Specific Studies Completed or Emerging
- Future directions and opportunities
- Data Sharing
- Rapid HIV Testing
- More excellent ideas!
31. IMPORTANCE OF HIV/AIDS IN THE CTN
- Prevention and treatment of HIV are vexing
problems 26 years since emergence of AIDS - CTN is conducting multi-site clinical trials with
emerging results that address HIV/AIDS - 27 studies in the CTN, N8K, many topics
- HIV/AIDS efforts are essential in the CTN
4Key CTN Tasks
- Establish a clinical research enterprise to
- Foster bi-directional collaboration between
researchers and practitioners - Conduct multi-site clinical trials to determine
the effectiveness of drug abuse treatment
interventions in real-life settings - Transfer research results to treatment programs,
clinicians, and their patients to improve the
quality of drug abuse treatment - Utilize the CTN as a platform for
research/training
5NIDA AIDS Domestic Research Priorities (FY 07)
- Racial/ethnic disparities
- Improving HIV therapy
- Improving HIV therapy access, utilization,
adherence, and effectiveness - Spread of HIV among drug users and their networks
- Role of non-injection drug use in facilitating
HIV transmission - Prevention interventions among drug users in
criminal justice system - Adolescent development, decision-making,
impulsivity
6More NIDA Research Priorities
- Intervention strategies to coordinate and improve
treatment and services for HIV, drug abuse, and
co-occurring conditions (e.g., HCV) - Medical consequences of HIV/AIDS, drug use,
comorbid conditions, and HIV treatment - Enhanced testing and counseling strategies
- Support training of new AIDS researchers
- --------------------------------------------------
----------- - http//www.nida.nih.gov/about/organization/arp/ARP
-current.htm PRIORITIES - http//www.nida.nih.gov/about/organization/arp/ARP
-index.htm FUNDING OPPORTUNITIES
72. MECHANISMS TO ADDRESS HIV/AIDS IN CTN
- A third of the budget at NIDA
- All studies measure address HIV risk behaviors
- HIV/AIDS Special Interest Group (SIG)
- Affiliated studies using the CTN platform
- Several specific AIDS studies (reviewed today)
83. SPECIFIC HIV/AIDS STUDIES IN THE CTN
- Larry Brown
- Infections Substance Abuse
- Bob Booth
- HIV HCV Intervention in Drug Detoxification
Settings - Susan Tross
- HIV/STD Safer Sex Skills Groups for Women
- Don Calsyn
- HIV/STD Safer Sex Skills Groups for Men
- Lisa Metsch
- HIV Rapid Testing and Counseling
-
9Larry Brown Infections Substance Abuse(CTN
012)
- Aim Describe HIV services in CTN Community
Treatment Programs (CTPs) - Scope 269 administators of CTPs, 1723
clinicians, 48 state administrators - Some results Services related to state reqs.
(.77 vs .65). HIV testing (49) - More info JSAT, 2006
10Bob Booth HIV HCV Intervention in Drug
Detoxification Settings(CTN 017)
- Aim Efficacy of TAU, counseling Ed, or
therapeutic alliance intervents. - Scope 646 IDUs in residential treatment
- Some Results Very high HIV risk38 used used
needles 40 of women 2 sex partners - More Info Robert.Booth_at_UCHSC.edu
11Susan Tross HIV/STD Safer Sex Skills Groups for
Women(CTN 019)
- Aim Test efficacy of intervention
- Scope 600 women in drug treatment programs
- Some Results Pending
- More Info st130_at_columbia.edu
12Don Calsyn HIV/STD Safer Sex Skills Groups for
Men (CTN 018)
- Aim Test efficacy of intervention
- Scope 646 men in drug treatment programs
- Some Results More sex risk in outpatient
non-methadone stimulant users show more risk - More Info Calsyn_at_u.washington.edu
13Lisa Metsch HIV Rapid Testing and Counseling
(CTN 032)
- Aim Test efficacy of rapid test and counseling
in treatment prgrams - Scope Multi-site clinical trial
- Status In development
- More Info Metsch_at_med.miami.edu
144. Future Directions and Opportunities
- Data Sharing http//www.ctndatashare.org/
- DATASETS POSTED FOR 11 STUDIES
- CTN 001 Bup/Nx vs. Clonidine in Inpatients
- CTN 002 Bup/Nx vs. Clonidine in Outpatients
- CTN 004 Motivational Enhancement Therapy
- CTN 005 --Motivational Interviewing
- CTN 006 -- Motivational Incentives in Drug Free
Clinics - CTN 007 --Motivational Incentives in Methadone
Clinics - CTN 008 Baseline
- CTN 009 Smoking Cessation
- CTN 011 Telephone Enhancement
- CTN 012 HIV Infections
- CTN 016 Patient Feedback
- 1 Secondary Analysis Womens HIV risk across
studies
15HIV RAPID TEST
- More about this in next paper!
LM slide
16MORE EXCELLENT IDEAS FOR THE FUTURE!
- Recent CTN Call for Concepts
- HIV SIG had developed 10 ideas
- Consulted with NIDAHIV Research office and CCTN
- Submitted 3 among 20 from whole CTN
- 2 were among the 3 forwarded up the line
- 1 remaining was incorporated into a planning team
- Studies needed
- Role of drug abuse treatment in HIV related
problems - Impact of HIV/AIDS on drug use, other risk
factors - Feasibility of large-scale interventions in
treatment - Best-practice solutions to ethical dilemmas
- There are Vital Issues in Need of Attention
17IN SUMMARY
- HIV/AIDS -- an essential issue in CTN
- both products and processes
- Several mechanisms address the issues
- Budgetary Mandate -Active SIG
- Platform Studies - HIV-Specific Studies
- Secondary Analysis
- Future studies in planning process and needed
18ACKNOWLEDGEMENTS
- Support from NIH/NIDA P50DA09253, U10DA15915,
R01DA11344, R21DA20369 - Staff Patients San Francisco General Hospital
- Colleagues Advisors, Grant Colfax, Jennifer
Hettema, Raul Mandler, Lisa Metsch Jose
Szapocznik, Brad Shapiro, Betty Tai, Susan Tross,
19MORE INFOat CTN website
- http//www.nida.nih.gov/CTN/Index.htm
20THANK YOU!
- Contact information
- James.Sorensen_at_ucsf.edu
- 415-206-3969