Title: Patrick VAN BOGAERT, MD, PhD Clinique de Neurologie P
1Patrick VAN BOGAERT, MD, PhDClinique de
Neurologie PédiatriqueLaboratoire de
Cartographie Fonctionnelle du CerveauUniversité
Libre de BruxellesHôpital Erasme
Status epilepticus in infancy
2What is status epilepticus (SE)?
- ILAE 1993 (guidelines for epidemiologic studies)
- Single epileptic seizure gt 30-min duration
- Or series of epileptic seizures during which
function is not regained between ictal events in
a gt 30-min period - ILAE 2001 (glossary of descriptive terminology
for ictal semiology) - Seizure that shows no clinical signs of arresting
after a duration encompassing the great majority
of seizures of that type in most patients - Or recurrent seizures without interictal
resumption of baseline central nervous system
function
3From Raspall-Chaure et al, 2007
4So the concept of SE relies on the occurrence of
seizures
- An epileptic seizure is a transient occurrence of
signs and/or symptoms due to abnormal excessive
or synchronous neuronal activity in the brain
(ILAE 2005) - Different types of SE according to the type of
seizure - Convulsive SE (CSE)
- Non-convulsive SE
- Absence SE (typical or atypical)
- Myoclonic SE
- Focal SE
- (Electrical SE during slow-wave sleep)
- (Hypsarrhythmia)
5Myoclonic SE in infancy
- In the course of a non-progressive encephalopathy
- Psychomotor retardation from 3-4 m, no regression
- Myoclonic sz may be confounded with a movement
disorder - Important etiologies Angelman, Rett, other
chromosomal deletions - In the course of a progressive encephalopathy
progressive myoclonic epilepsy (PME) of infancy
6Clinical case 1
- M, 15 m
- Admitted for febrile seizure (GTCS)
- Global psychomotor delay from age 4 m, no
regression - Exam jerky movements, possible ruptures of
contact
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9Absence of hybridation signal on 15q11.2
Angelman syndrome
10Clinical case 2
- F, 4y
- Sz from age 3y (GTCS, absences), refractory to
AED - Mental deterioration, progressive ataxia
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12Curvilinear intracellular inclusionslate
infantile neuronal ceroid lipofuscinosis
13Epidemiology of SE
Peak age lt 1 year related to febrile SE
From Raspall-Chaure et al, 2007
14Classification of SE according to etiology (ILAE
1993)
- Acute symptomaticin a previously normal child
- Remote symptomaticin the absence of an
identified acute insult but with a history of a
pre-existing CNS abnormality - Idiopathic epilepsy relatedin children with
prior diagnosis of idiopathic epilepsy - Cryptogenic epilepsy relatedin children with
prior diagnosis of cryptogenic epilepsy
15Limits of this classification for CSE,
particularly relevant in infants
- Acute symptomatic 2 very different conditions
that need to be individualized - Febrile (excluding CNS infection)
- Due to an identified neurological insult
(infection, trauma,...) true acute symptomatic! - Some children with CSE associated with fever have
pre-existing neurological abnormalities,
including epilepsy, while others are previously
neurologically normal acute vs acute
on remote
16Distribution of etiologies
From Raspall-Chaure et al, 2007
17- About 1/2 cases occurs without history of prior
seizures - Fever-associated SE is the most frequent
situation in infants (Chin et al 2005 95 cases) - Febrile 59
- Previous neurological abnormality (acute on
remote) 21 - CNS infection (acute symptomatic) 20bacterial
meningitis 12viral encephalitis 8
18Treatment rationale for early intervention
From Raspall-Chaure et al, 2007
191. CSE may lead to brain injury
- Animal model Kainate induced SE leading to
hippocampal sclerosis - SE-induced MRI changesusually reversible but
irreversible changes reported (focal atrophy,
mesial temporal sclerosis, hemispheric damage)
Huang et al, 2009
20CSE and hippocampal injury
- Relationship between MTS and prolonged febrile sz
controversial (cause or consequence) - MRI after CSE (Provenzale et al, 2008)
- Acute hypersignal in hippocampus 7/11
- Subsequent hippocampal atrophy 5/7 (with sz in
4)
21HHE syndrome hemiconvulsions-hemiplegia-epilepsy
- Clinical case M, 10 years
- Age 2 years Febrile convulsive status
epilepticus - Refractory epilepsy since age 4 years, R
hemiparesis, severe mental retardation - Sz-free after hemispherotomy
222. GABAergic mechanisms fail and seizures become
self-sustaining and pharmacoresistant
Miniature IPSCs from dentate gyrus granule cells
of SE (dotted line) and controls (solid line)
demonstrating smaller amplitude and prolonged
decay in SE
The change of mIPSCs with SE reflects a decrease
in the number of functional postsynaptic GABA-A
receptors
Naylor, 2005
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24The four phases for CSE management
- Prehospital
- First-line treatment in emergency room
- Second-line treatment after failure of
benzodiazepine - General anesthesia
25PrehospitalBuccal MDZ to replace rectal DZ
Authors Design specificities N (ages) EfficacySF at 10m for 1h (MDZ vs DZ) Safety Conclusion
McIntyre Lancet 2005 Emergency room 219 (gt6m) 56 vs 27 plt.01 relapse 8 vs 17 Respiratory depression 5 (12 pts, intubation in 5) MDZPO gt DZIR
Mpimbaza Pediatrics 2008 Emergency room, data for children without malaria 108 (3m-12y) 73.5 vs 44p0.02 Respiratory depression 1 MDZPO gt DZIR
RCT comparing buccal midazolam and rectal
diazepam (both 0.5 mg/kg)
26Administration
- Following time frames in care plan
- Ensure patients head is upright and in the
midline to ensure solution is given (and stays in
the buccal space)
27Administration 2
- It is accepted best practice that the medicine
dose should be split equally between both spaces - If it is a very small dose this may not be
practical
28Administration 3
- Carefully insert the syringe between the lower
jaw and the cheek - Ensure it is in the buccal space by pointing it
downwards - Give half of medicine in one space then transfer
the syringe to other buccal space and complete
dose
29Administration tips
- Do not massage gums as you are likely to move the
solution out of the buccal space - Keep patient wherever possible in that position
for 5-10 minutes - If medicine is lost or swallowed do not repeat
- Always remember to Time seizure
- Note any differences from normal
- Keep patient safe throughout
- All guidelines say not to put anything in
patients mouth this is the exception
30Who is at risk for SE?
- In children with epilepsy (2 unprovoked sz)
- Risk 9.5
- Risk factors history of SE, younger age ar
onset, symptomatic etiology
Berg et al, 2004
31First-line treatment in emergency room
generalities
- Maintenance of adequate airways, breathing and
circulation (ABC)IV access with saline, not
glucose - Termination of seizure and prevention of
recurrence - Diagnosis and initial therapy of life-threatening
causes (e.g. hypoglycemia, meningitis, cerebral
space-occupying lesion)
32First-line treatment in emergency room benzo IV
- 2 RCT, MDZ nasal against DZ IV, both at 0.2 mg/kg
(Lahat 2000, Mahmoudian, 2004) - NS in terms of safety and efficacy
- Sz controlled more quickly with IV DZ
- Prospective population-based treatment of CSE
(Chin et al, 2008) - Prehospital treatment (DZ IR) efficient in 22
- IV lorazepam 3.7 times greater likehood of sz
termination than DZ IR - for each minute delay from onset of CSE to
arrival at emergency room, 5 cumulative increase
in the risk of the episode lasting gt 60 min.
33Second-line treatment after failure of
benzodiazepine phenytoin
- gt 2 doses BZP associated with
- SE lasting gt 60 min
- respiratory depression
- IV phenytoin 9 times greater likehood of sz
termination than paraldehyde IR
(Chin et al, 2008)
34Second-line treatment VPA as an alternative to
PHT?
- Phenobarbitalprobably similar efficacy than PHT
but - greater incidence of respiratory depression
- same mechanism of action than benzos
- Paraldehydeno experience, interesting if no IV
access - Valproate one randomized trial against PHT
(Agarwal et al, 2007) - Same success rate (88 VPA vs 84 DHT)
- No difference for AE or recurrences
35Refractory CSE
- Definition SE refractory to 2 drugs(usually
benzo and PHT, or benzo and VPA) - Alternatives (no RCT in children!)
- VPA or PB if not used previously
- Benzo continuous infusion
- Barbiturates thiopental or pentobarbital
- Propofol
- New AEDs levetiracetam, topiramate
- Ketogenic diet
36Thiopental (pentothal)
- Ter Maaten et al 1998 n10
- EEG clean but death 10/10
- Gestel et al 2005 n34
- propofol efficacy 64 death 2/22
- thiopental efficacy 55 death 6/20
- Rantala et al 1999 n54
- complications during thiopental 50
- seizure relapse after thiopental 53/54
- back to previous seizure frequency 78
- significantly more drugs needed
37Thiopental cerebral blood flow
- Wada et al 1996
- decrease from 123 to 84ml/mn (19) for regional
CBF in rat - De Bray et al 1993
- significant decrease for CBF (Doppler) in
children - more important for brain trauma than for controls
- Drummond et al 1995, Guo et al 1995.
- Anesthesia protection of brain and brainstem in
a context of ischemia
- Thiopental-induced CBF decrease
- is beneficial if infarct or oedema (occasionnal
SE, trauma) - is deleterious if epilepsy (CBF increase is
needed if SE)
38Refractory SE new AEDs
- Levetiracetam IV
- Gamez-Leyva et al 2009
- 34 (11-90y), no response to PHT/VPA
- SE stopped in 71 by LVT
- Gallentine et al 2009
- 11 (2d-9y), 15-70mg/kg/d (m30mg/kg/d)
- SE stopped in 45 by LVT (m40mg/kg/d)
- Topiramate
- Kahrima, et al 2003
- TPM by tube effective in 3 children
39Ketogenic diet
- Diet resulting in a continuous cetosis
- Low carbohydrates, high fat
- Ratio Lipides / (Protides Glucides) 31 or 41
- Now ready to give (Ketocal)
- Encouraging preliminary data in children
- Francois et al 2003
- SE stopped in 3/6 RSE, maintained for 2 y
- Villeneuve et al 2009
- 11/22 children with RPE were responders
- Better response in patients with SE (plt.04)
- Nabbout et al, 2010
- FIRES 7/9 were responders within 48 h following
ketonuria
40Recommendations in different countries
Country 1st line 2nd line 3rd line
Cochrane (UK) MDZPO/IN LRZ VPA, PHT, DZIV
US BZ, PHT VPA, LVT anesthesia
Denmark DZIR DZIV, VPA FosPHT, MDZIV, anesthesia
France DZIR DZIV, CNZIV PHT, PB
Clonazepam IV non available, Lorazepam non
available, Midazolam and Lorazepam non
available
41Protocol of CSE proposed by the Canadian
Paediatric Society
- First-line MDZ 0.5 mg/kg IB, or LRZ 0.1 mg/kg IV
- After 5 min, repeat 1 time benzo
- After 10 min PHT 20 mg/kg IV over 20 min
- After 20 min PB 20 mg/kg IV over 20 min (but VPA
20 mg/kg IV over 5 min probably better
alternative!) - After 40 min intubation and midazolam continuous
infusion - 0.15 mg/kg bolus then 2 mg/kg/min infusion
- Increase as needed by 2 mg/kg/min q5 min
- Bolus 0.15 mg/kg with each increase in infusion
rate - Maximum infusion rate 24 mg/kg/min
- Taper after 24 hours
- After 1 hour and 40 min thiopental/pentobarbital
Friedman 2011, http//www.cps.ca
42Outcome seems to be more related to etiology (?)
- Mortality 5, no death in febrile SE
- Morbidity (new deficits)
- Acute symptomatic gt 20
- Febrile and unprovoked lt 15
- In the epilepsy related group, occurrence of SE
does not affect social and educational outcomes - The relationship of CSE with mesial temporal
sclerosis or subtle neurocognitive dysfunction,
and the effect of age at CSE, seizure duration,
or treatment on outcome have not yet been
clarified.
From Sillanpää et al (2002) and Raspall-Chaure et
al (2007)
43Conclusions
- Establish your protocol according to drugs
available in your country - Among benzos, MDZ should be encouraged both for
prehospital (buccal) and refractory SE
(continuous infusion) because half-life short
(1-3 h) - PB should be avoided
- Monitor EEG in continuous if possible in each
case of refractory CSE