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Introduction of Immunology

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Immunology Diseases / Immunity Immunity Diseases / Immunity Immunity * * Microbiology Antigen (Ag) Immunity Antigen (Ag) The state of protection from ... – PowerPoint PPT presentation

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Title: Introduction of Immunology


1
???
Immunology
2
Diseases / Immunity
3
Immunity
Microbiology
Antigen (Ag)
4
Self/non-self recognition
Antigen (Ag)
??
Non-self
Immunity
The state of protection from infectious disease
5
?????????
Principles of innate and adaptive immunity
Immune cells
Activation of immune cells
Function of activated immune cells
Immune organs
6
From innate to Adaptive immunity
Interdependence
????
7
Immunity
Innate (non-specific) immunity Adaptive
(specific) immunity
8
Innate immunity
9
Innate immune response
10
Immune cells
Chemotaxis (????)
11
Innate immunity Phagocytes Phagocytosis
????
????
  • Attachment
  • Ingestion
  • Formation of
  • phagosome
  • Fusion of
  • phagosomes
  • and lysosomes
  • 4. Digestion
  • 5. Release

??
12
Phagocytes
Myeloid cells
????
????
Granulocytes
Macrophages Dendritic cells
??????
????
Neutrophils Eosinophils
??????
??????
13
Granulocytes
??????
Neutrophils Eosinophils
Basophils Mast cells
??????
??????
????
??????
(Degranulation)
14
Immune cells
Innate immunity
Adaptive immunity
WBC
Myeloid cells
Lymphoid cells
???(??)
Macrophages/ Dendritic cells
T
B
NK
????
APC Ag-presenting cells
(Natural killer cells)
Granulocytes
CD8 (Tc)
CD4 (Th)
????
(Helper)
(Cytotoxicity)
???T??)
15
(No Transcript)
16
Activation of immune cells
Activated immune cells
Ag
Cell surface modification
17
Production of soluble mediators
Ag
Soluble mediators
Cytokines (IL), chemokines, .
????
????
18
Mutual stimulation
19
Cell-cell interaction
20
Proliferation
Differentiation
(Functional) Effector
????
21
Clusters of differentiation (CD)
Morphology Function Cell surface marker
?11-4,5
22
Function of immune cells
Ag tracing is based on Ag location
Ag Innate Adaptive
Extracellular Phagocytes B cells
Intracellular NK Tc cells (Altered self)
23
Adaptive immunity
B cells
Humoral immunity Cell-mediated immunity (CMI)
CD4 Th
CD8T (Tc)
24
Organization of lymphoid system
Primary (Central) Bone marrow Thymus
25
Organization of lymphoid system
Secondary (Peripheral) Lymph nodes
Spleen Peyers patches
Ag
26
Lymph node distribution in the body
27
Lymph node
28
Immunity on mucosa surface
29
Function of immune cells
Inflammation (cells, soluble mediators)
(????)
30
(DC)
From local innate immunity (in skin) to adaptive
immune response
31
Adaptive immunity
APC Ag-presenting cells
Innate immunity
32
Function of immune cells
Ag tracing is based on Ag location
Ag Innate Adaptive
Extracellular Phagocytes B cells
Intracellular NK Tc cells (Altered self)
CD4 Th
APC
33
From innate to Adaptive immunity
Interdependence
????
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