Kidney biopsies at Southampton General Hospital, UK

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Kidney biopsies at Southampton General Hospital,
UK

• Dr Pankaj Deshpande

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SGH

• Kidney biopsies between Jan 2001 to Oct 2003
• 24 children identified
• 17 boys, 7 girls
• Age range 2 years to 16 years

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Exclusion criteria

• Children with nephrotic syndrome who had
  haematuria
• Children with HSP who had a kidney biopsy for
  persistent proteinuria

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Demographics
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Features

• 6 children with associated proteinuria (2
  nephrotic range)
• 2 children with renal dysfunction(1 male, 1
  female)
• 2 children with familial haematuria
• Except for haematuria, no complications of the
  biopsy

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Haematuria
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Results

• 6 children with proteinuria (5 boys, 1 girl)
• MCGN, 3 Alports and 2 IgA
• 3 children with familial haematuria
• 2 normal, 1 Alports
• 2 children with renal dysfunction
• PSAGN

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Literature

• Birmingham Childrens Hospital
• Renal biopsies in 322 children
• 1975-1996
• Continuous microscopic / recurrent macroscopic
  haematuria for gt 6 months

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Results

• IgA 78 children (24) (61/17MF)
• Alport 86 children (27) (50/36)
• Thin basement membrane 50 (15) (18/32)
• Hilar vasculopathy 28 (9) (23/5)
• Miscellaneous 32 (10) (14/18)
• Normal 48 (15) (32/16)