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Introduction to Pathology for 3rd yr. Medical student, Medical Faculty Naresuan University

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Title: Introduction to Pathology for 3rd yr. Medical student, Medical Faculty Naresuan University


1
Introduction to Pathologyfor3rd yr. Medical
student, Medical FacultyNaresuan University
By S. Pongsabutra MD.13 June 06
2
Student must understand and can explain the
followings - 1. Course Syllabus of
Pathology I(405311) (??????????????????
??????????????????? 1
??????????????????????????????????????????????????
) 2. The meaning and general knowledge
concern with study the pathology
3
A. Course Syllabus Pathology I
(???????????????????) 1. Content And
Learning objective 2. Topic of learning
3. Organization of teaching learning 4.
Teaching media 5. Learning place 6.
Assessment 7. Time table study 8.
References ?????????????????????????
???
4
  1. The meaning and general knowledge concern with
    study the pathology - 1. The meaning of
    pathology and scope of pathology. 2. How to
    study the pathology? Strategy of
    learning Tactics of learning 3.
    The general main causes of diseases.
    4. Applied pathology to solve clinical
    problems.

5
Pathology is the study of abnormal state of
body particulary in morphological and functional
changes of organ, tissue, cell. (Pathology
Gr.PathosLogos)
Pathology is the medical science specialty
practice concerned with all aspects of Diseases
6
MEANING WHAT IS THE DISEASE
(
)
?????????????????? ????, ????????????? ???.
7
Disease is the disorderly function(symptom,sign)of
organ system of body (cell tissue organ). or
Disease disease (suffering, torture of that
body which show off as abnormal sign and symptom)

8
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9
STRATEGIC PLAN
A. THEORETICAL STUDY
B. TACTICAL (PRACTICE)
( ????????? ????????? ??????
??????????????????????????? )
( ?????????????????????? ?????????? )
Functional changes
Anatomical changes
10
THEORETICAL STUDY
A
Main object is to know the nature of
DISEASE by study as the following - 1.
Etiology( causes of diseases ) 2.
Pathogenesis (mechanism of diseases) 3.
Pathological changes (structural
change Lesion) 4. Clinical feature
(functional structural changes presented as
symptom and sign of patient) 5.
Complication ???????????? ????????????????????
???? ? 6. Prognosis ( prediction the
future of victim)
11
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12
TACTICAL STUDY
B
??????????????????????????????????
?????????? ???????????????? ??? ??????????????
??????? ????????
??????????? ??? ??????????????????????????????????
??? ????????????????????
???????????????????? ????????? ???
??????????????? ????????? ?????????? ???????? ????
13
??????????????????????
Normal squamous cell vs
abnormal squamous cell? Structure
Normal mucosal small bowel vs abnormal mucosal
small bowel?
Normal liver vs abnormal liver Function
Normal blood sugar vs abnormal blood sugarof

..etc..organ, tissue, cell
14
??????????????????????????????? (???)????
Anatomical and Functional changes
??????????
????????????????????????????????????????
??????????????????????????????
??????????????????????????????????????????????????
??? ?
????????????? Gross Anatomy
Micro Anatomy ??????????????? Embryology
??????????????????? Physiology included
Biochemistry Immunology..etc..
???????????????? 5 ??? ?? ????? ?????
?????????eg. ????????????? ?????????????? ???,
????, ??? ??????? ????????????????????
???? Physic, ???? ???????????????????????????
???? ????????????????????, x-rays, MRI
?????????????????? ???? Immunochemistry
??????????????????????? ? ??? ?????????????.???
15
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16

???????????????????????????????The general main
causes of disease
????? 1
????? 2
????? 3
Congenital Disorders
DisordersofSelf defensemechanism
inflammation Immune disorder
Formation of Tumor Non Neoplastic
Neoplastic
Congenitalanomaly
HereditaryDisease
Familial diseases
Abnormal Growth Development
(Biological orNon Biological causes)
????? 4
Unclassified Degeneration. Metabolic
Disorderseg. DM. .???.......
17
Compensate to be normal Heart
rate
18
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19
Macroscopic ????????????? Aortic Valve
Acute bacterial vegetative endocarditis
20
????????? ???????????????
Left ventricular hypertrophy(1.8cm)
21
????????? hypertrophy heart
22
????????? Microscopic ?????????????????
Acute pulmonary edema
23
Macroscopic Abnormal cut surface
characterized by multiple ,
varying in size , up to 1 cm. , grey
white , masses
24
Microscopic Abnormal both in size , shape
of liver Cell
25
Macroscopic Focals loss Liver parenchyma
Multiple lesions
26
Microscopic Foreign body in Hepatic bile
duct ( Fluke
??????????????????? )
27
Macroscopic Severe , Diffuse dilatation of
sinusoid with reddish brown color
Passive congestion of liver
28
Microscopic Changes characterized by loss
of Liver cord around
central vein meaning ? Central necrosis of
Liver
29
Liver
Macroscopic Abnormal surface diffuse
nodular lesions , size 1-2 mm. and Shrinkage
30
Liver
Macroscopic Abnormal cut surface show
diffuse grey-white spots size vary
to 1-3 mm. through out cut surface
31
APPENDIX TISSUE SLIDE PROCESSING
For Microscopic Study
32
Any time
Necropsy
Biopsy
During operation in OR.
Chemical Fixation for light microscopy
(formalin)
Freezing
Specimen
Dehydration (ethanol)
Clearing (xylene)
Infiltration (xylene/paraffin)
Embedding (paraffin)
Sectioning (microtome)
Sectioning (cryostat)
Mounting (glass slide)
Removal of paraffin
Rehydration
Staining (H E) and / or histochemical
reaction
Light Microscopy
33
REFERENCES
1. Anderson s Pathology, 10th edition Edited by
Ivan Damjanov, James
Linder, Vol. I, The history of
pathology pp 1 11. 2. Concise Pathology,
3rd edition, Edited by P.
Chandrasoma C.R. Taylor, Introduction The
discipline of Pathology, pp xiii
xiv 3. Robbins and Cotran Pathologic Basis of
Disease, 7th edition, Edited by Kumar Abbas
Fausto Introduction to Pathology pp 4

34
???? Post-Test
1. ?????????? ??? ???????????????????????????
(disease) ???????????????????? (structure)
??????????????? (physiology or function)
??????????????????????????????????????????????????
???????????????????????????? ?????????
???????????????????? ? ??? cell, tissues,
organsBody
35
2. ??? ??? ??????????????????????????????
(symptom) ????????????????? (sign)
???????????????????????????????? ????? ??????????
(cell, tissue, organ)
36
3. ??????????????????????????????????????????????
????? ??????????????????(Anatomic Pathology)
??????? ??????????????????????????????????????????
??? cell, tissue, organ ?????? ???????????????????
??????????????? (static conditiondead tissue)
??????????????????????????????????
37
????????????????(Clinical Pathology) ???????
?????????????????????????????????????????????
cell, tissue, organ ??????????????????????????????
???????? dynamic condition ???????????????????????
??????????????????????????????????????? ?
??????????????????????????????????????????????????
?????????????????????????
38
4. ??????????????? ??????? ???????????????????
??????????????????????????????????????????????????
????????????????. ???????????????????????? 1.
????? Etiology 2. ????? Pathogensis 3. ?????
Pathologic changes (lesion) 4. ????? Clinical
manifestation 5. ????? Complication 6. ?????
prognosis
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