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Immunotherapy

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Immunotherapy Personal statistics John Weisnagel, M.D. Database Sept 1992-June 2006: 23,577 patients Undergoing immunotherapy: 2,393 pts (10.14%) Perennial Rx (all ... – PowerPoint PPT presentation

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Title: Immunotherapy


1
Immunotherapy
  • Personal statistics
  • (updated, 2013)
  • John Weisnagel, M.D.

2
Database
  • Sept 1992-Dec 2012 31,150 patients
  • Undergoing immunotherapy 2,533 pts (8)
  • Perennial Rx (all-year long) 1,490 (58.8)
  • Pre-seasonal Rx (one injection per week (for 4 or
    9 weeks depending on type of Rx, 1-2 months
    preceding the specific pollen season) 1020
    (40.2)
  • 23 pts having recd both types of treatment.

3
Efficacy of immunotherapy
  • Of the 2,533 treated since 1992,
  • 1046 replied to the question of the effect of
    their treatment (excellent, very good, good,
    slight or no change) when reminders were sent
    them about renewals
  • Treatment was
  • Perennial in 596
  • Pre-seasonal in 450

4
Perennial Treatment
  • 596 patients
  • Asthma 53 (8.8)
  • Asthma pollinosis 74 (12.4)
  • Asthma rhinitis 86 (14.4)
  • Pollinosis 155 (26)
  • Rhinitis 225 (37.7)

5
Efficacy of Perennial treatment in 596 patients
Excellent Very good Good Slight Ineffective
Asthma 53 4 (7.5) 17 (32) 16 (30.1) 7 (13.2) 9 (16.9)
Asthma pollinosis 74 8 (10.8) 18 (24.3) 24 (32.4) 14 (18.9) 10 (13.5)
Asthma rhinitis 86 7 (8.1) 25 (29) 19 (22) 23 (26.7) 12 (13.9)
Pollinosis 155 23 (14.8) 57 (36.7) 51 (32.9) 16 (10.3) 8 (5.1)
Rhinitis 225 21 (9.3) 67 (29.7) 62 (27.5) 53 (23.5) 22 (9.7)
6
Pre-seasonal Treatment
  • 450 patients with pollen allergy, some with
    associated asthma
  • Reported effect
  • Excellent in 82 (18.2)
  • Very good in 135 (30)
  • Good in 111 (24.6)
  • Slight in 48 (10.6)
  • Ineffective in 24 (5.3)

7
Efficacy summary
Perennial treatment averaged 18.5 for slight
improvement 28.9 for good 30.3 for
very good 10.1 for excellent while
ineffective in only 11.8 Pre-seasonal treatment
averaged 10.6 for slight improvement 24.6
for good 30 for very good
18.2 for excellent while ineffective
in only 5.3
8
Pre-seasonals
  • Center-Al
  • Suspal
  • Pollinex R
  • Other tyrosine preps.

9
Perennials
  • Mixtures
  • House dust mite pollens
  • House dust mite molds
  • House dust mite pollens molds

10
Bottom line
  • These personal statistics, though anecdotal,
    reflect the conclusion of the many studies
    published on the benefit of immunotherapy.
  • Both forms of therapy, perennial and pre-seasonal
    have similar benefits.
  • Immunotherapy is still an effective treatment in
    respiratory allergy, and should be considered
    when pharmaceutical therapy is inadequate.
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