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Endometriosis

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Endometriosis Sanja Na inovi Mentor: A. mega Horvat Definition endometrial-like cells appear in areas outside the uterine cavity endometrial-like cells are ... – PowerPoint PPT presentation

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Title: Endometriosis


1
Endometriosis
  • Sanja Nacinovic
  • Mentor A. Žmegac Horvat

2
Definition
  • endometrial-like cells appear in areas outside
    the uterine cavity
  • endometrial-like cells are influenced by hormonal
    changes

3
Epidemiology
  • typically seen during the reproductive years
  • occurs in roughly 5-10 of women

4
Sings and symptoms
5
Infertility
  • link between infertility and endometriosis
    remains enigmatic

6
Other symptoms
  • constipation
  • chronic fatigue
  • mild to severe fever
  • headaches
  • depression
  • hypoglycemia (low blood sugar)
  • anxiety

7
Causes
  • the exact cause of endometriosis remains unknown
  • Retrograde menstruation
  • Coelomic metaplasia
  • Genetics
  • Transplantation
  • Environment

8
How to diagnose it?
  • laparotomy
  • laparoscopy
  • ultrasound

9
Co-morbidity
  • ovarian cancer
  • non-Hodgkin's lymphoma
  • leiomyoma
  • autoimmune disorders
  • hypothyroidism

10
Possible locations
  • ovaries
  • fallopian tubes
  • back of the uterus
  • front of the uterus
  • uterine ligaments
  • pelvic and back wall
  • intestines
  • urinary bladder and ureters

11
Staging
  • Stage I (minimal)
  • Stage II (mild)
  • Stage III (moderate)
  • Stage IV (severe)

12
Markers
  • high levels of estrogen
  • low levels of progesterone
  • antigen C-125

13
Treatments
  1. hormonal medications - progestins, oral
    contraceptives, Danazol, aromatase inhibitors
  2. other medications - NSAID, Diclofenac

14
  • surgery- excision, hysterectomy, presacral
    neurectomy
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