Radiation Therapy Trials Quality Assurance: - PowerPoint PPT Presentation

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Title:

Radiation Therapy Trials Quality Assurance:

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RTOG, Philadelphia (RTOG) QARC, Providence ... 3) RPC still developing methods for remote review of dosimetry ( TLD? ... edge dosimetry and lateral penumbra, ... – PowerPoint PPT presentation

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Title: Radiation Therapy Trials Quality Assurance:


1
  • Radiation Therapy Trials - Quality Assurance
  • patient safety
  • adherence to protocol constraints
  • uniformity of patient treatments
  • efficient review of patient data

2
CTEP supported CLINICAL TRIAL QA CENTERS RTOG,
Philadelphia (RTOG) QARC, Providence (COG,
CALGB, SWOG, ECOG, ACOSOG, - - - ) RPC, MD
Anderson (NSABP, GOG and physical dose QA for ALL
groups)
Review item chart images study chairs
archives
Conventional Post Tx Few hard copy- largely
2D Travel to QA center Hard copy- difficult
searches
Advanced tech trials Real-time and pre-Tx Gbytes
of digital multi modality Remote review by
internet Digital full datasets
ATC cooperative agreement developmental ITC,
RCET implementation RTOG, QARC, RPC
3
RPC IMRT Phantom Test
  • RPC tests ability of each institution to deliver
    IMRT by asking facility to
  • Scan RPC phantom (CT, MRI, etc.)
  • Generate an IMRT plan according to defined
    protocol
  • Deliver treatment to phantom
  • Return phantom and dosimeters to RPC for
    evaluation.
  • Submit digital planning data to the ITC
  • RPC uses ATC Remote Review Tool to analyze data

4
Phantom Results Comparison between institutions
plan and delivered dose. Criteria for agreement
7 or 4 mm DTA
30 of institutions failed HN phantom on the
first attempt
5
RTOG 0022 Dry-Run TestPHASE I/II STUDY OF
CONFORMAL AND INTENSITY MODULATED IRRADIATION FOR
OROPHARYNGEAL CANCER
  • Of 18 Institutions that were ultimately
    credentialed
  • Number of submissions it took to meet
    credentialing guidelines
  • 6 institutions required 1 submission
  • 9 institutions required 2 submissions
  • 3 institutions required 3 submissions
  • ( these were large academic centers)

6
NCI IMRT PROTOCOL REQUIREMENTS
  • 2002 guidelines for IMRT use in clinical trials
    were established to ensure the safety and
    comparability of these radiation treatments.
  • 2005 NCI announced revisions in these guidelines
    allowing use of IMRT for intra-thoracic
    treatments.
  • 2006 specific guidelines for use of IMRT for
    intra-thoracic treatment protocols with
    respiratory gating

7
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8
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9
  • ISSUES (some) CONCERNING
  • PROTON THERAPY (multi-institutional trails)

1) No national standard for proton calibration
2) Two different calibration protocols in use
among US facilities
3) RPC still developing methods for remote review
of dosimetry ( TLD?)
4) RPC still developing a proton compatible
phantom
5) ATC still verifying compatibility of proton Tx
planning computers
6) Proton dose computation algorithms standards
at the QA centers in addition to secondary
neutron production modeling
7) Protocol specific field placement
verification, critical nature of heterogeneity
corrections, GTV margins re SOBP distal edge
dosimetry and lateral penumbra,
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