Drug

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Drug delivery technology
Drug delivery technology is an integration
of Bio-technology Nano-technology Biomedical
technology
A new specialisation!!
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Drug delivery technology
The 65 billion US drug delivery system industry
will continue to grow at an average rate of 28
over the next 5 years By 2007, drug delivery
will account for 39 of all pharmaceutical sales
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Drug delivery technology

• Oral insulin administration (encapsulated,
  controlled release)
• Pulmonal insulin delivery
• Needle insulin administration
• Pumps (external and implantable)
• Microelectromechanical systems for drug
  administration
• Nanoparticles
• Nanopumps (microfluidic systems)
• Polymers
• Liposomes (wavelength specific release)
• Transdermal delivery

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Drug delivery technology
Biomedical engineers and physicians at CWRU and
University Hospitals of Cleveland (UHC) have
created an innovative drug delivery device, a
biodegradable polymer rod smaller than the tip of
a lead pencil, to help treat liver cancer.
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Drug delivery technology
Nanotechnology provides a unique possibility to
create systems that can better deliver drugs to
tiny areas within the body. Nano-enabled drug
delivery also makes it possible for drugs to
permeate through cell walls, which is of critical
importance to the expected growth of genetic
medicine over the next few years.
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Drug delivery technology

• Transdermal delivery
• Jet injection
• Patches and enhancer technologies
• Microneedles/-knives
• Laser ablation
• Controlled heat
• Light (e.g. lightsensitive liposomes)
• Ultrasound (sonophoresis/ phonophoresis)
• Electroporation
• Iontophoresis

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Drug delivery technology
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Drug delivery technology
Jet injection
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Drug delivery technology
Mathematical PK and PD models
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Drug delivery technology

• Basic Courses
• Drug delivery systems and technology
• Biomaterials and biocompatibility in drug
  delivery
• Engineering approaches to drug delivery
• Mathematical models (PK-PD)
• Nanoparticles and implantable systems
• Polymers and Biomaterials
• Pharmacology
• Physiology
• Immunology
• Cell Biology

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Drug delivery technology

• Project Related Courses
• Oral and buccal drug delivery devices
• Pulmonary drug delivery devices (e.g. Dry powder
  inhalers and Nebulizers)
• Drug Eluting Stent Technology (stents coated with
  these drugs )
• Percutaneous Drug Delivery Technology (e.g.
  Electroporation)
• Ophthalmic/nasal drug delivery
• Colloidal Drug Delivery Technologies
  (microparticles (1 to 1,000 µm) or
• nanoparticles (1 to 1000 nm) )
• Site/organ specific Drug delivery
• Microneedles and Needle-free Drug Delivery
  Technology
• Microchips and Microspheres in Drug Delivery
• Micro and nanotechnology in drug delivery
  Microfabrication, MEMS (micro-
• electromechanical systems) and BioMEMS
  Technology
• Drug Delivery Applications (e.g. Cardiovascular
  disease, Cancer, Diabetes)
• Ethical issues concerned with drug delivery
  applications

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Project proposals (many together with industry)

• Drug delivery technologies to increase he
  efficiency of transport across
• the blood-brain barrier
• Implantable devices in e.g. chemotherapy drug
  delivery
• Systems for sustained release and controlled
  delivery of drugs with
• remote control possibilities e.g.
  radio-controlled drug delivery
• Intravascular nanopore membrane devices for e.g.
  antiangiogenesis therapy
• of metastatic cancer
• Determining the rate of release for a model drug
  from a controlled release
• implant
• Electrokinetic drug delivery e.g application of
  low voltage electrical current,
• sound or thermal energy to the skin to enhance
  drug transport
• Drug delivery fibers e.g. dressing materials and
  fibers designed for wound
• healing
• Design computerized inhalers
• Built-in sensors to monitor the drug delivery
  pumping rate e.g. insulin pump

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Drug delivery technology

• Industries interested
• Novo Nordisk
• Alza
• Johnson and Johnson
• Cara
• 3M
• Coloplast
• Becton Dickinson

• Partners interested
• Aalborg Hospital
• Pharmaceutical University
• Aarhus University

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Drug delivery technology

• Working group
• Lona Christrup (Pharmaceutical Faculty,
  Copenhagen University)
• Camilla Staahl (Aalborg Hospital)
• Anne Olesen (Aalborg Hospital)
• Parisa Gazerani (Aalborg University)
• Henrik Egsborg (Novo-Nordisk)
• Bjarne Asah (ASAH Medical)
• Peter Andersen (Risø)
• Daniel Otzen (bio-technology)
• Thomas Garm Pedersen (nanotechnology)
• Lars Arendt-Nielsen (biomedical technology)

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Drug delivery technology

• Why should I.21 provide this specialisation
• Globally it is a fast growing area
• No other institutions in Denmark offer this
  specialization
• At the University it fulfills the strategy about
  interdisciplinary efforts
• If Inst. 21 is not proactive biotechnology will
  be (life science)
• We have collaborators in the field
• Hospital do have GCP unit for testing new devices
• A way to get substantial funding from industry

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Drug delivery technology