A model of cortical neuronal circuit with dynamic synapses

1
A model of cortical neuronal circuit with dynamic
synapses

• All synapses have the capability of
• short- and long-term plasticity
• Each thalamic input is independent
• and may be of arbitrary pattern
• The number of PCs may be
• arbitrary

PC - pyramidal cell (shown with its 19
compartments) FFI - interneuron realizing feed
forward inhibition RI - interneuron realizing
recurrent inhibition. Open triangles - excitatory
synapses Filled triangles - inhibitory
synapses. Types of synaptic conductances are
indicated in callout boxes next to corresponding
synapses (AMPA, NMDA, GABAA, GABAB). Model input
is the impulses applied to thalamic inputs.
2
Color-coded plots of degree of synchronization S
versus PC-PC excitatory synapse initial weight
(horizontal axis) and Interneuron-PC inhibitory
synapse initial weight (vertical axis).
Interneuron PC inhibitory synapse initial weight
Interneuron PC inhibitory synapse initial weight
PC PC excitatory synapse initial weight
PC PC excitatory synapse initial weight
Synapses between PCs are facilitating at around
10 Hz and depressing at higher frequencies
Synapses between pyramidal cells (PC) are
depressing at all frequencies.