Finding ADH and OT Neurons in the Hypothalamus

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Finding ADH and OT Neurons in the Hypothalamus
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Finding ADH and OT Neurons in the Hypothalamus
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Finding ADH and OT Neurons in the Hypothalamus
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Finding ADH and OT Neurons in the Hypothalamus
recording electrodes
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Finding ADH and OT Neurons in the Hypothalamus
OT ICC
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Finding ADH and OT Neurons in the Hypothalamus
AVP and OT in situ hybridization
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Why is ADH called AVP?
Why is AVP called ADH?
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Regulation of Blood Pressure and Volume Via
Regulation of Water Metabolism
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Osmotic Regulation of ADH
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Pressure and Volume Changes Regulate ADH
Blood Pressure Volume
Requires 10 to 20 change
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What happens when ADH is lacking?

• Diabetes Insipidus
• gt3 liters of urine per day
• 295 to 300 mOsm for blood
• Constant thirst
• Two types
• - central (low ADH)
• - nephrogenic (low response to ADH)

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Why is nursing an infant such a let down?
OT
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Positive Feedback Loop
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Psychogenic Stimulation of OT Release
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Mammary Gland Myoepithelial and Secretory Cells
Functionally speaking, do ADH and OT have
anything in common?
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Pressor Effects of ADH (AVP)
Afferent
Efferent
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ADH Action on Water Reabsorption
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ADH Stimulates Aquaporin Insertion into the
Membrane
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Positive Feedback Loop
E2 increases OT-R
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ADH Signal Transduction Systems
V2
H2O permeability
V1 or V2
V1
pressor effects
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OT Signal Transduction Systems