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Salivary Gland Tissue Engineering:

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Acinus. Duct. Salivary Cell Loss. Acinar cell loss leads to loss of functional salivary gland tissue ... Eliminates need for saliva substitutes and sialogogues ... – PowerPoint PPT presentation

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Title: Salivary Gland Tissue Engineering:


1
Salivary Gland Tissue Engineering
  • TSI Award Overview

Christopher A. Sullivan, M.D. January 10, 2007
2
Slobber
Spittle
Salivate
Saliva
Dribble
Drool
Spit
Slaver
3
Xerostomia
Dry mouth
Uninspired
Unexciting
Dehydrated
Uninteresting
Waterless
Dull
Boring
Dreary
Monotonous
4
Aim
Slaver your attention in a
Dull talk about dribble
5
Grant Aims
  • Scientific
  • Educational

6
Salivary Fluid
  • Essential role in upper GI function
  • 1.5 liter daily
  • Swallowing lubricant
  • -amylase digestion of starch
  • Neutralizes oral pH
  • Maintains dental enamel
  • Immune function (IgA)
  • Facilitates speech

a
7
Acinus
Parotid Gland
Duct
Submandibular Gland
8
Salivary Cell Loss
  • Acinar cell loss leads to loss of functional
    salivary gland tissue
  • Sjogrens Syndrome (1 million , USA)
  • Radiation therapy for upper aerodigestive cancer
    (40,000/y, USA)
  • Age related degeneration
  • Tumor
  • Surgery

9
Salivary Hypofunction
  • Loss of normal salivary flow
  • Dry mouth
  • Dental decay
  • Swallowing dysfunction
  • Nutritional deficits
  • Decreased quality of life

10
(No Transcript)
11
Management
  • No cure for salivary hypofunction
  • Saliva substitutes
  • Transient effect, frequent administration
  • Oral sialogogues
  • Stimulate salivary flow
  • Not reliable
  • Primary side effect (sweating)

12
Salivary Tissue Engineering
  • Physiologic solution
  • Steady source of saliva
  • Eliminates need for saliva substitutes and
    sialogogues
  • Autologous cells eliminate need for systemic
    immunosuppression.

13
Hypothesis
  • Creation of functional salivary gland tissue
    that is composed of a patient's own glandular
    cells could provide a physiologic solution to
    salivary gland hypofunction.

14
Clinical Scenario
Cells are grown and expanded
Cells are seeded on scaffolds
Implantation into salivary bed
Autologous salivary cell harvest
15
Proof of Concept
Human Clinical Trial
Disease Model
Autologous Animal Model
16
Scientific Aims
  • Specific Aim 1 Optimize a culture system of
    human salivary gland cells.
  • Specific Aim 2 Create a salivary gland
    hypofunction model in a rodent.
  • Specific Aim 3 Engineer human salivary gland
    tissue in-vivo.

17
Educational Aims
  • Develop and refine scientific methods
  • Learn to manage a budget
  • Develop working understanding of the rules of
    intellectual property
  • Commercialization strategies

18
Execution of Grant Aims
  • Scientific Meeting Weekly
  • Optimize salivary cell culture system
  • Optimize animal disease model
  • Engineer salivary tissue in-vivo
  • Education 2008
  • WFIRM/OTO/CCC tutorials and education
    opportunities local/regional national
  • Spring 2008 WFUHS Innovation Commercialization
    at Babcock School
  • Presentation of findings June 2008 at American
    Head and Neck Society

19
Execution of Grant Aims
  • Commercialization
  • US patent application filed 2/1/05
  • US patent supplemental amendment filed 12/282007
  • Working with OTAM on potential industrial
    partners
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