PROMOTING HEALTHY AGING: EXPLORING THE TRUTH IN APPROPRIATE SEX HORMONE REPLACEMENT AKA for GONADOPA - PowerPoint PPT Presentation

Loading...

PPT – PROMOTING HEALTHY AGING: EXPLORING THE TRUTH IN APPROPRIATE SEX HORMONE REPLACEMENT AKA for GONADOPA PowerPoint presentation | free to view - id: caa7c-ZDc1Z



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

PROMOTING HEALTHY AGING: EXPLORING THE TRUTH IN APPROPRIATE SEX HORMONE REPLACEMENT AKA for GONADOPA

Description:

Neil Burman , Preventative Specialist Internist, ... 1977 Byrd & Burch(Tennissee): in 1000 women post hysterectomy, Premarin for decades ... – PowerPoint PPT presentation

Number of Views:144
Avg rating:3.0/5.0
Slides: 21
Provided by: neilb4
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: PROMOTING HEALTHY AGING: EXPLORING THE TRUTH IN APPROPRIATE SEX HORMONE REPLACEMENT AKA for GONADOPA


1
PROMOTING HEALTHY AGINGEXPLORING THE TRUTH IN
APPROPRIATE (SEX) HORMONE REPLACEMENT (AKA for
GONADOPAUSE).Neil Burman , Preventative
Specialist Internist,Fellow of Kronos Longevity
Research Foundation, Phoenix Arizona.Member of
the International Menopause Society
www.imsoc.com and Aging Male Society
www.ISSAM.ch .Healthpan Life Research
Foundation, Cape Town neil.burman_at_gmail.com
2
All (Reproductive) hormones including melotonin
and thyroid start declining after age
30yrs. Some often do not - eg insulin,
cortisol, estrone may remain high-ish into
old age.  Most hormones are seriously
imbalanced by middle age even in men eg
high ratio of insulin-cortisol-estrone to
androgen MEDSCAPE 2000 Unknown mechanisms
link aging-related parallel declines in the
growth-hormone axis (somatopause), gonadal axis
(gonadopause), and adrenal androgen secretion
(adrenopause).
3
Hundreds of HUMAN (REPRODUCTIVE) HORMONES
messengers made in virtually every organ
controlling all functionsbrain melotonin
serotonin growth dopamine GABA
acetylcholinesex hormones antidiureticstimula
ting releasing hormones for eg thyroid,
adrenals, gonadorgan hormones thyroid,
parathyroid, thymus, heart, lung, liver,
stomach, bowel.BRAIN- FSH, LH, prolactin, sex
hormones P, TT, EADRENAL pregnenolone -
DHEA dehyroepiandrosterone GONADS
progesterone, estradiol E2, testosterone
TT HuSHR FAT (often the biggest organ in
women) eg breast estrone E1
Hormone Replacement therapy Replacing them in
deficiency to youthful daily physiological
production dose level eg human insulin for
diabetes with true BID HRT . Hormone
Therapy HT Using them in high ie
pharmacological dose eg cortisone for allergy,
or substituting eg horse estrogen Premarin, or
phyto/plant hormones or synthetics eg Estinyl,
progestin.
4
STEROIDS cholesterol sterol
cycloperhydropentenophenanthrine- C17
derivatives -include cortisol, aldosterone
vitamins D digoxin
  • and SEX- Hormones - DHEA and
  • Progesterone- reproduction, docility
    immunosuppressant...
  • Testosterone- libido- mating sperm anabolic
    muscle, bone, heart, circulation, warrior,
    mechanical/maths, Insulin sensitivity
    immunomodulatory
  • Estrogen reproduction breasts, fat caring
    intuitive, artistic bone insulin sensitivity
    circulation, immuno-stimulatory.

5
HISTORY of Human Sex Hormone Replacement HuSH
600 BCE China human
androgen estrogen HRT ! 1930s
synthesis of estradiol, testosterone,
progesterone. since lt1944 on sale and used in
RSA as injections, tablets, suppositories,
implants and creams. 1942 Wyeths premarin
first marketed
. 1950-1953 Chicago Trial of
Stilbestrol in Pregnancy - holocaust.1953
Masters/Johnson - 1st randomised controlled trial
13mo RCT of HuSH - TT E2 injection -
dramatic improvement.Since 1960 Tvedegard
Moller (Denmark) Reiter (London) dramatic
improvement in advanced heart/circulatory disease
with TRT1971 1st Premarin RCT - Wulf
Utian(MBChB Wits) at Groote Schuur Hospital.By
1975 -Premarin adverse reports- increases
thrombosis, breast cancer. 1980 Henderson ea
San Francisco breast cancer rises steadily
after 10yrs with accumulating premarin dose.
6
THE COMMON CHRONIC MAJOR DISEASES OF AGING in
all of which sex hormones play a major role as
both cause effectSKELETAL
osteoarthritis, fractures,
rheumatoidVASCULAR heart-attack/failure
gangrene, stroke, kidney failureBRAIN
- anxiety-depression, memory, dementia
Parkinsons METABOLIC overweight - diabetes
lipidemia, hypertension, IMMUNE increased
infections cancer breast, prostate,
colonWASTING frailty, falls,
incontinence, prolapse, heart failureSENSORY
blindness, deafness,
falls, GONADOPAUSE loss of libido,
responsiveness impotence COSMETIC
skin/ Ts/Bs sagging/ dryness, hair loss,
obesity
7
CORRECTIBLE RISK FACTORS FOR AGING
DISEASES1-4 Smoking Sloth Gluttony
stress for most people only disaster
stops these habits eg heart attack or death.
BID non-oral HuSH are major help if deficient/
imbalanced.5. Metabolic syndrome insulin
resistance - diabetes / lipidemia-
replace TT/E2 deficiency with BID non-oral
HuSH, Supplement fish oil, galega, cinnamon
6- 8 Deficiency/depletion of
Vitamin-Mineral-Biologicals
supplements 10 minerals 13 vitamins
Biologicals CoQ10, carnitine, carnosine,
arginine, ribose, 5HTP, GABA, melotonin,
cysteine, MSM, glucosamine, chondroitin,
phosphatidylserine, lutein, and herbs eg
sawpalm huperzine A together the above
reduce new diabetes, all major disease thus
mortality by well over 1/3 9. genes
seldom matter
.
8
WHY HRT IS CRUCIALNOT ONE NEW SYNTHETIC ie
PATENT DESIGNER DRUGof the past 50 years for
chronic use most of which have major
hazards - antidiabetics,
antihypertensives, antidepressants,
anti-inflammatories,antiarrhythmics,
antianginal, antiheartfailure,
anti-impotence , anti-osteoporosis,
anti-parkinsons, anti thrombotics
anti-dementia , painkillers,
statins, progestins,
SERMs , nor any
phyto-(plant) estrogens  - NONE reduce
obesity AND ALL major common degenerative
diseasesAND ALL mortality compared to the
natural supplements..HRT IS STILL THE BEST
PREVENTION FOR MOST.
9
THE MAJOR ORAL HRT STUDIES IN WOMEN
  • OBSERVATIONAL STUDIES
  • 1977 Byrd Burch(Tennissee) in 1000 women post
    hysterectomy, Premarin for decades
  • lowered all mortality breast cancer mortality
    fractures, atho more breast cancer presented.
  • The Prospective Nurses Study (1996) the Cache
    County study (2002) less dementia, heart
    disease, osteoporosis,
  • colon cancer, arthritis, diabetes
  • when oral HT PremPro - was taken from
    menopause.
  • 1990s
  • study from Univ Ulm Germany premenopausal
    women with ischemic heart disease have much lower
    estrogen levels than the healthy women.
  • HRT even after breast cancer reduces all
    mortality
  • including cancer deaths.
  • .
  • .

10
The Million Womens Study a meaningless farce
user bias. RANDOMISED CONTROLLED TRIALS of
PremProHERS Heart Estrogen Study 1998
ESPRIT UK 2002 women mean 60 - 67yrs,
post heart attack HRT made no difference.
WHI Womens Health initiative 2002 2004In
16000 overweight women mean age 63yrs, for mean
5-7yearsIf HT started well after 60yrs less
fractures, diabetes, colon cancer, but No
difference in deaths ie cancer, heartattack,
more thromboses gallstones strokes memory loss
but this was NOT appropriate HRT started soon
after menopause.
11
APPROPRIATE HORMONE THERAPY
  • RCTS 1953 - 1st randomised controlled
    trial for 13mo Masters/Johnson- HuSH - TT E2
    injection at mean age 73yrs - dramatic sustained
    improvement within 6 weeks.
  • RCT WHI Womens Health initiative 2002
    2004 In 1000
    overweight women mean age 55yrs, for mean
    5-7years
  • Ie Women under 60yrs at start -
  • 1/3 reduction in all deaths major disease
  • and reduction in carotid artery thickening.
  • RCT The Finland Oulu 2006 Oral Estadiol
    progestin post menopause
  • for 9 years in 419 women NO serious event s
    (deaths, cancer cardiovascular)
  • in those on the low dose of estradiol plus
    progestin levonorgestrel.

12
HRT hysteria and myths HRT is a thalidomide
disaster - after the WHI 2002 paper and the MWS
Million Womans Study   caused suffering if
not deaths for millions of women ( doctors) who
were suddenly denied or frightened off
appropriate hormone replacement.  It is
certainly inappropriate if not unethical to
start traditional oral HT eg 0.625
Premarin or 1mg estradiol with the matching
progestin dose in women - especially the
elderly - who are now in general very
overweight.         we stopped using such
ineffective therapy 15 years ago.       Such
gross oral hormone overdose both fattens, and
suppresses vitality-giving androgen.
13
OBSERVATIONAL STUDIES of testosterone in women
40year experience with implants or injection of
depot E2 TT from menopause (St Louis Atlanta
Augusta Montreal London Denmark Australia
Cape Town) such patients have reduction in all
major diseases.2004 Prof Morrie Gelfand,
Quebec (Past President of the International
menopause Society) said It might be wise to
consider adding androgen to the estrogen or
estrogen-progestin regimens in the appropriate
patients.
14
PRIMATE STUDIES OF HRTThe Window of
OpportunityProf Thomas Clarkson at Wake
University USA has led a team of scientists in
landmark controlled trials in primate -
cynmologus monkeys- this decadeshowing that
with doses of HT equivalent to those in women for
the human equivalent of 15 years,starting HT at
menopause (castration) is beneficialbut
starting HT after the equivalent of age 60 yrs
when vascular disease is already established
is too late if anything HT may aggravate heart
and stroke.
15
PHASES OF GONADOPAUSE (Menopause- ovaries/
Andropause - testes) RELATIVE SEX HORMONE
IMBALANCE / ABSOLUTE DEPLETION
(androgen, estrogen) that occurs in
MOST OLDER MEN AND WOMEN 1. immediate hot
flashes/sweats moodiness - seldom permanent
due to adaptation..
(and menstrual irregularity/cessation)  2
.intermediate to long term increasing fatigue
and girth decline in skin /eyes/ hair, sexual
and genito-urinary function  the
above problems by populist misconception are
commonly presented to surgeons
gynecologists and urologists whereas they are
specialist endocrine, internal medicine problems
.  3  long term deficiencies causes
increasing major chronic degenerative diseases -
which through neglect of appropriate early
replacement, present in half of people
as sudden death by arrhythmia/ heart-attack/
stroke or present to internists, often
as fractures , dementia , cancers, dementia
ie grossly late.
16
Premature gonadal failure and hormone imbalance,
infertility and cancer, (in men women) Are
increasing the past 40 years due toearlier
obesity and its consequences

the (pollution) Feminization of Nature
(Deborah Cadbury Nils Skakkebaeck) food
adulteration by sugars, growth hormones
preservatives
 increasing stress
sterilization
longevity maternal even grandmothers
hormone exposure
 increasing survival from
prematurity and cancer
 legalized dangerous drugs
like alcohol, tobacco, aspartame, statins, sugar
.(Early) hysterectomy and sterilization
(which can mostly be avoided) -  -
aggravate heart disease through early loss of
uterine and gonadal hormones, And if done
early, increase death-rates up to 7 fold.
17
In female rats, monkeys and humans, trials show
that oral or systemic estrogen alone increases
breast cellular activity and thus breast cancer
risk.Adding progestins increases this risk
altho the combination reduces all-cause and
breast cancer mortality..But adding balancing
BID testosterone reverses all risks of
estrogen.(Schleyer-Saunders Greenblatt
Gelfand Gambrell Dimitropolous Zhou Bondi
Whitehead Studd Buster Vliet Shippen
Hansen Burger Davis Davies ea Cape Town.
).xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxSimil
arly in androgen deficient men, physiological ie
non-oral BID testosterone replacement for decades
reduces all major degenerative diseases and
all-cause mortality including from diabetes,
heart disease, cancer (the rate of new prostate
cancer is halved, and easily dealt with if it
occurs in about 0.5 per year).
18
In Conclusionwe as specialist internist
endocrinologists (unlike most surgeons) -
follow basics - that all micronutrient
deficiencies should be replaced, and should be
as physiological - close to nature- as
possible.Because of oral-hepatic digestion (as
with insulin, sex hormones) and strong
evidence of first-pass risks in the liver and
elsewhere, , we advise patients to avoid oral
estrogen, testosterone progestinsif patients
choose to take the oral route should use the
most natural (ie BID human) forms in the
lowest micronised doses not horse urine or
soy, black cohosh.BUT (Twice) daily BID creams
allow the best flexibility (compared to depot
injections or implants at weekly to three-monthly
intervals) - but in all cases blood levels
should ideally be measured before and at
intervals on replacement (as with eg insulin or
thyroid) to check that levels are adequate but
not excessive.This monitoring cannot routinely
be done with phyto- or xeno- hormones like
premarin, Estinyl, progestins, synthetic
androgens or soy etc. .
19
THE BUSINESS-ACADEMIA MONOPOLY
INDUSTRY/POLITICAL. ACADEMIC INDIFFERENCE TO
NON- PATENT PREVENTATIVES THERAPIES  For
the Disease Industry FOR BUSINESS- - Patent
Drug/Technology Companies and those they
support heavily (druggists, medical journals,
medical researchers /universities,
private researchers, hospitals, politicians,
regulators)  ONLY DSEASE PAYS. NATURAL
CHEAP PREVENTION DOES NOT PAY.  This applies
possibly even to some doctors and Medical
Schemes (which are mostly share-owned by
corporations with cross-interests in the disease
industry) and Government-   if curative disease
incidence and costs are high,-   jobs are
created and massive tenders, and taxes, are at
stake.. ..-   and Medical Scheme Premiums can
justifiably rise  
20
Regulators (whose salaries are paid by the
costly patent drugs they register and
regulate) in all capitalist countries eg
the Commonwealth, EU, USA , are under pressure
to control, schedule for prescription-only
natural non-patentable and highly effective safe
  supplements like vitamins, minerals,
herbs, biologicals including BID hormone
creams.  Need we ask why, when the modern
high-tech but non-curative designer- Disease-
and Fast-Food- Agricculture- Industry (and
medical Insurance/ medical schemes that go with
it) Is a trillion-dollar business?  But
cheap preventatives (often old, mostly
non-prescription microfood supplements and
organic fresh foods) can greatly delay if not
virtually eliminate the chronic major
degenerative diseases of aging, and thus the
majority of admissions to private hospital
centers and hospitals?
About PowerShow.com