Career Opportunities at sanofi pasteur

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Career Opportunities at sanofi pasteur

• March 19, 2007.

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sanofi aventis Vision
Because health matters.
A group inspired by a powerful vision Find new
compounds to prevent, combat and eradicate
diseases around the world. Provide therapeutic
and preventive solutions geared to populations in
both industrialized and developing
countries. Support with equal dedication
innovative medicines and vaccines, mature
products, OTC medicines and generics. sanofi
pasteur is the vaccines business of
sanofi-aventis Group.
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Competition
Sales Results

• We are the Leader in a Concentrated Market

Big Five have 83 of market 100 competitors
comprise remaining 17
Merck Vaccines 14
Sanofi pasteur 26
GSK Bio 24
Others 17
Wyeth 14
Novartis 5

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Main products
Vaccines against 20 diseases
Bacterial diseases Pertussis Diphtheria Haemop
hilus influenzae type b infections
Meningococcal meningitis Pneumococcal
infections Tetanus Tuberculosis Typhoid
fever Cholera
Viral diseases Yellow fever Mumps Poliomyeli
tis Measles Rubella Influenza Hepatitis
A Hepatitis B Rabies Japanese encephalitis
Chickenpox
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sanofi pasteur in brief
2006 net sales 2,533 millions (22.7 growth
rate over 2005) Staff more than 8,500
employees More than a billion doses of vaccines
sold to protect more than 500 million people in
the world A wide range of vaccines against 20
diseases A presence in 150 countries 15 of our
sales reinvested in RD
FTEs at December 2005
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Research Development
Staff aproximately 1 500 people
Toronto
Marcy-lEtoile
Swiftwater
15 of sanofi pasteur net sales reinvested in
RD
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HR Staffing Results for 2006
Professionalism and Excellence
Professionalism and Excellence

• Total number of positions in 2006 under
  recruitment 368
• 299 total were filled 81
• 273 of these positions were filled within tiers 2
  3 (levels 9 to 16)
• 36 internal candidates

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sanofi pasteur Research Development

• sanofi pasteur is focused on developing new and
  improved vaccines for every stage of life. The
  companys scientists are working in several
  areas
• Developing new vaccines for infectious diseases
  for which no vaccines exist.
• Continuous efforts to improve the effectiveness
  and tolerability of existing vaccines.
• New vaccine combinations that will protect
  against several diseases simultaneously, thus
  reducing the number of injections,
• New technologies and routes of administration

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Where Process Development Fits into the Picture
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The Process Development Pathway

• Cell Viral Culture
• Cell Banks
• Viral seeds
• Develop bioreactor process
• Clinical manufacturing

• Formulation Stability
• Stability Assessment
• GMP Formulation Filling
• Assays

• Purification
• Develop Purification Process
• Prepare Material for Testing/Assay Development
• Clinical Manufacturing

• Bacterial Fermentation
• Seeds
• Develop fermentation process
• Clinical Manufacturing

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Bacterial Fermentation Personnel and Expertise
Expertise

• Personnel
• Scientific Staff - 6
• Technical Staff - 9
• Support Staff - 2

Microbiology Molecular biology Biochemistry C
ell biology Biochemical engineering Scale-up cGMP
manufacturing cGMP facility management Facility
and equipment validation
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Application of Technologies to Enhance Project
Support
Fermentation and primary recovery process
development
Clinical lot manufacture
Seed production
Scale-up
DNA microarray
Statistical design
Batch Expert process control and automation
pH STAT Online biomass sensor Membrane
technologies
Acquire and maintain leading edge technical
competencies. Support projects by improving
efficiency and quality.
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Cell Viral Culture Platform

• Mandate
• Application of animal cell culture technology to
  support the development and manufacture of
  vaccine candidates and licensed products

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Cell Viral Culture Personnel and Expertise
Expertise

• Personnel
• Scientific Staff - 5
• Technical Staff - 9
• Student - 1

Microbiology Molecular biology Cell biology
Biochemical engineering Tissue
culture Virology Scale-up cGMP manufacturing Facil
ity and equipment validation
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Downstream Processing of Biopharmaceuticals
Cell culture medium
Host cell protein
CIP
rDNA
Downstream Purification
Purified Bulk
Nucleic acids
Viruses
Pyrogen
Extractable leacheables
Cells
Viruses
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Purification- Skills and Expertise

• 15 staff members 7 scientists (5 Ph.D) and 8
  technologists
• Temp staff 1 associate Scientist 1
  technologist
• Others 2 co-op students
• Background and Training
• Biology, Biochemistry, Molecular Biology, Natural
  Science, Immunology, Biotechnology
• Expertise
• Purification process development/ optimization
  scale-up and GMP production
• Protein chemistry biophysical/ biochemical
  characterization Test development structural
  biology immunology, molecular biology animal
  model development fermentation formulation
  tissue culture

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Formulation Stability Personnel and Expertise
Expertise

• Personnel
• Scientific Staff - 6
• Technical Staff - 9
• Support Staff - 2

Biochemistry Cell biology Pharmacology/pharmacy
Analytical chemistry Organic chemistry cGMP
manufacturing Facility and equipment validation
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Formulation Stability- Key Deliverables

• Screen and select
• Buffers
• Lyo/liquid presentation
• Excipients, Preservatives
• Stabilizers
• Adjuvants
• Process definition for final product formulation
• Key process variables/ranges established
• Critical parameter identification for Ph III
  studies
• Optimal final presentation
• Stability studies- Developmental, Design
• Shelf life preliminary assessment

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Research Canada

• 4 Research platforms
• Microbiology
• Immunology
• Biochemistry
• Bioinformatics
• Other departments
• Analytical Sciences and Assay Development (ASAD)
• Clinical Development
• Regulatory Affairs
• Quality Assurance
• Intellectual Property

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Skills and Experience

• Basic life sciences
• Biology
• Microbiology
• Virology
• Molecular biology
• Lab experience
• Microbiology/tissue culture
• Molecular biology
• Biochemistry
• Organization and record keeping
• Analytical
• Problem-solving

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Skills

• Enthusiasm
• Initiative
• Teamwork
• Detail orientated
• Communication
• Computer skills

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How to Apply

• On-line http//www.sanofipasteur.ca
• Career opportunities
• Careers in Canada
• Electronic resume
• Simple and short
• - 2 pages in length
• - minimize fancy formats, icons etc.
• - name and contact information clear and
  prominent
• - work history, education, work related skills
• omit personal information such as age, marital
  status, nationality, interests
• list accomplishments in addition to duties and
  responsibilities

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BioTalent Canada

• http//www.biotalent.ca
• Non-profit organization
• Help companies and educational institutions to
  develop the highly trained staff necessary for
  commercial success of biotechnology in Canada
• Services
• PetriDish
• on-line employment bank
• http//www.petridish.ca
• Career Focus programme
• Patent Protection in Biotechnology
• Making Sense of Biotechnology
• Good Laboratory Practices (GLP)
• Good Clinical Practices (GCP)
• Sanofi Aventis Biotech Challenge

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Questions

• How did I plan my career path?
• How does one get promoted in a biotechnology
  company?