Title: What are the gapsfuture plans for filling these gapswhat areas need looking at IMPLANTSPROSTHETICS
1What are the gaps/future plans for filling these
gaps/what areas need looking atIMPLANTS/PROSTHETI
CS
Evidence for up-to-date clinical dental practice
a review of 10 years of the Cochrane Oral
Health Group30th-31st May 2006, Manchester
- MARCO ESPOSITO
- Senior Lecturer in Oral and Maxillofacial
Surgery, School of Dentistry, and Editor of the
Cochrane Oral Health Group, The University of
Manchester, UK Assoc Prof in Biomaterials,
Göteborg University, Sweden
2AN OVERVIEW
- From 11 Cochrane reviews on osseointegrated
dental implants and 1 review on prosthetics - Updated to March 2006
- http//www.cochrane.orghttp//www.cochrane-oral.m
an.ac.uk
3- We shall discuss specifically the gaps of the
topics covered in the Cochrane reviews, since we
know what has been done in these fields. - It can difficult to discuss the gaps not knowing
what has been done (importance of the systematic
reviews). - However, additional gaps can be addressed by the
participants.
41 BONE AUGMENTATION PROCEDURES
- A) to test whether and when bone augmentation
procedures are necessary. - B) to test which is the most effective bone
augmentation technique for specific clinical
indications. - Trials were divided into 3 broad categories
according to different clinical indications - major vertical and/or horizontal bone
augmentation - implants placed in extraction sockets
- treatment of fenestration around implants.
51 BONE AUGMENTATION PROCEDURES
- Last literature search October 2005
- 13 RCTs with 330 participants (17 RCTs excluded)
- Bone augmentation of athrophic edentulous
mandibles (1 trial) - Stellingsma 2003 short implant vs sandwich bone
graft - Sinus lifting (3 trials)
- Wannfors 2000 1-stage block vs 2-stage
particulated bone - Hallman 2002 1-stage particulated bone vs
80Bio-Oss/20bone vs 100 Bio-Oss - Szabó 2005 2-stage particulated bone vs 100
tricalciumphosphates (Cerasorb)
6DESCRIPTION OF STUDIES
- Vertical augmentation (2 trials)
- Chiapasco 2004 bone titanium barrier vs
distraction osteogenesis - Merli submitted particulated bone resorbable
barrier plates vs titanium barrier - Immediate implants in fresh extraction sockects
(4 trials) - Cornelini 2004 resorbable barrier Bio-Oss
- Chen1 2005 non-resorbable vs resobable
particulated bone - Chen2 2005 particulated bone vs control
- Chen manuscript Bio-Oss vs Bio-Oss resorbable
barrier - Fenestrations and dehiscence around implants (3
trials) - Dahlin 1991 non-resorbable barrier vs control
- Carpio 2000 GBR bone/Bio-Oss resobable vs
non-resorbable - Jung 2003 resorbable barrier Bio-Oss rhBMP-2
(placebo)
7Titanium reinforced barriers for vertical
GBRpreoperative postoperative
8CONCLUSIONS
- In atrophic edentulous mandibles there are more
implant failures, complications, pain, cost and
longer treatment time using sandwich bone
grafts than short implants. - Sinus lifting with 100 bone substitutes (Bio-Oss
and Cerasorb) might work with sinus floor lt 5 mm. - It is possible to augment bone vertically,
however complications are frequent and it is
unclear which is the most effective technique.
9CONCLUSIONS
- It unclear whether augmentation procedures are
needed in postextractive sockets and which is the
most effective augmentation procedure. In sites
treated with Bio-Oss barriers, the gingival
margins may be positioned 1.2 mm higher than in
sites treated with barriers alone. - GBR allows bone augmentation at fenestrated
implant, but it is unclear whether it is needed,
and which is the most effective technique. - Complications with GBR procedures are common.
There might be an association between bone
retrieved with bone filters also using a
dedicated suction device and infective
complications.
10Where are the gaps
- When bone augmentation procedures are actually
needed? - Which procedures are associated with the least
discomfort and complications for the patients,
without jeopardizing (ideally improving) success
rates? - Sinus lift use of 100 bone substitutes.
- Vertical augmentation bone blocks, particulated
bone/bone substitutes and GBR, osteodistraction,
active molecules, split-crest techniques (only
for horizontal augmentation). - Postextractive implants grafting or not, what
to graft (bone or slow resorbable bone
substitutes), membranes? - Duration of follow-up.
11What trials are needed
122 Various implant characteristics/systems
- Is a surface modification, an implant shape, a
material or an implant system more effective than
the others? - Last literature search February 2005.
- 12 RCTs with 512 participants and 12 different
implant systems (19 RCTs excluded). 4 RCTs with a
5-year follow-up. - Minor statistically significant differences in
marginal bone loss and in the occurrence of
perimplantitis (20 risk reduction to have
perimplantitis at 3 years around implants with a
machined surface). No statistically significant
difference in failure rates. - We do not know whether any implant system is
superior to the others. It does not mean that
they are all the same!
13Where are the gaps
- Is the material, the macrodesign, the surface
characteristics or a combination of those
characteristics relevant for the success? - HA-coated implants?
- No statistically significant difference but not a
single study was powered to detect any! - Duration of follow-up
- Constant changes of surface characteristics
(mostly for marketing reasons!) - Is it better to have an early failure today or a
perimplantitis tomorrow? IN MEDIO STAT VIRTUS
Virtue stands in the middle?!
14What trials are needed
153 Immediate, early or conventional loading
- Is there any difference if implants are
immediately or early loaded? - Last literature search February 2004.
- 5 RCTs with 124 participants (2 RCTs excluded).
- For good quality mandibles we do not know
whether a difference does exist. It does not mean
that the techniques provide the same results!
16Where are the gaps
- Other clinical indications (fully edentulous
maxillas, partial edentulism)? - More failures can be acceptable?
- Factors affecting success of immediate loading.
- Immediate loading is more interesting for the
patients than early loading.
17What trials are needed
184 Maintenance
- Which is the most effective maintenance technique
or regimen? - Last literature search June 2004.
- 5 RCTs with 127 participants (9 RCTs were
excluded) electric (1 RCT) and sonic (1 RCT) vs
manual toothbrush phosphoric acid gel vs
debridement (1 RCT) subgingival vs chlorhexidine
mouthrinses (1 RCT) adjunctive Listerine
mouthrinse vs placebo (1 RCT). Follow-up 6
weeks-5 months. - Adjunctive Listerine mouthrinse reduces dental
plaque and marginal bleeding.
19Where are the gaps
- The longest follow-up was of 5 months!
20What trials are needed
215 Surgical techniques
- Is there any surgical technique associated to
higher success rates? - Last literature search September 2002.
- 4 RCTs (5 RCTs excluded). 2 RCTs compared 2
versus 4 implants with mandibular overdentures
(170 participants) 2 RCTs compared a crestal
surgical incision with a vestibular incision (20
participants). - We do not know whether a surgical technique is
superior, however, 2 mandibular implants are
sufficient to hold an overdenture. It does not
mean that all techniques are the same!
22Where are the gaps
- 1-stage versus 2-stage techniques.
- How many implants for overdentures.
- Incision techniques.
- Techniques to reconstruct the papillas.
- Techniques to increase the keratinized tissues.
- Flapless implant placement.
- Computer guided surgery.
23What trials are needed
246 Immediate, immediate-delayed and delayed
implants in extraction sockets
- How long time we need to wait to insert an
implant in postextractive sockets? - Last literature search March 2006.
- 1 RCT with 46 participants immediate delayed (ca
10 days) vs delayed (ca 3 months) implants.
Follow-up (loading) 1 year and half. - Patients treated with immediate-delayed implants
were more satisfied, and the peri-implant tissues
position was judged to be more appropriate in
relation to the neighbouring teeth by and
independent and masked assessor.
25Where are the gaps
- When placing the implants?
- Immediate is better than immediately-delayed for
the patients. - How to place the implants (subcrestally, slightly
lingually)? - Are bone augmentation procedures needed?
- What type of bone augmentation procedures are
needed? - How closing the flaps (1- or 2-stage procedure)?
26What trials are needed
277 Treatment of perimplantitis
- Which is the most effective treatment for
perimplantitis? - Last literature search March 2006.
- 5 RCTs with 106 participants (2 RCTs excluded)
- local antibiotics vs debridement (2 RCT)
- mechanical (Vector) vs manual debridement (1
RCT) - laser vs debridement and Chlorhexidine
irrigation/gel (1 RCT) - systemic antibiotics 2 different local
antibiotics resective surgery modification of
the surface topography. - Follow-up 3 months 2 years
287 PERIMPLANTITIS
297 Treatment of perimplantitis
- No difference between more complex procedures and
conventional debridement in light forms of
perimplantitis. - The adjunctive use of local antibiotics
(doxycycline) to debridement showed an
improvement of about 0.6 mm for PAL and PPD,
after 4 months in patients affected by severe
forms of perimplantitis (bone loss gt 50).
30Where are the gaps
- Length of the follow-up (1-5 years minimum).
- To start with the simpler procedures.
- To include enough patients to detect a
difference. - Clearly define whether early or more advanced
forms of perimplantitis are treated.
31What trials are needed
328 Preprosthetic surgery vs implants
- Which intervention is more effective
preprosthetic surgery and denture vs an implant
supported prosthesis? - Last literature search October 2005.
- 1 RCT with 60 participants.
- Patients treated with preprosthetic surgery and
dentures are less satisfied than patients who
received a mandibular overdenture on implants.
33Where are the gaps
34What trials are needed
359 Use of prophylactic antibiotics
- Does the use of prophylactic antibiotics decrease
postoperative complications and early failures? - Last literature search March 2006.
- 0 RCT.
36Where are the gaps
37What trials are needed
3810 Zygomatic implants
- Zygomatic implants with and without bone grafting
versus conventional implants in augmented bone. - Last literature search March 2006.
- 0 RCT.
39Where are the gaps
- Zygomatic implants can be associated with
frequent short and long-term complications (wrong
positioning, chronic sinusitis) and are very
difficult to be placed. - It is extremely difficult to remove them.
- Computer guided surgery?
- Long follow-up (1-5 years minimum)
40What trials are needed
4111 Hyperbaric oxygen therapy
- Does hyperbaric oxygen (HBO) therapy decrease
implant failures and complications in irradiated
patients? - Last literature search March 2006.
- 0 RCT.
42Where are the gaps
4312 Denture chewing surface designs
- Which denture chewing surface design should be
used? - Last literature search April 2004.
- 1 cross-over RCT with 30 participants (1 RCT
excluded) lingualised (maxillary anatomic and
mandibular non-anatomic) vs zero-degree teeth. - Patients preferred dentures with lingualised
teeth.
44Where are the gapsANY OTHER SUGGESTED TOPIC
45THANK YOU
- Comments to
- espositomarco_at_hotmail.com