Towards%20an%20Integrated%20Research%20Policy%20in%20the%20Area%20of%20Drug%20Discovery%20in%20the%20Arab%20Countries - PowerPoint PPT Presentation

About This Presentation
Title:

Towards%20an%20Integrated%20Research%20Policy%20in%20the%20Area%20of%20Drug%20Discovery%20in%20the%20Arab%20Countries

Description:

Including mechanisms to better utilization of their terrestrial and ... PARASITOLOGY LAB. THERAPEUTIC NATURAL PRODUCTS - ACTIVE COMPOUNDS - ACTIVE EXTRACTS ... – PowerPoint PPT presentation

Number of Views:119
Avg rating:3.0/5.0
Slides: 34
Provided by: biba8
Learn more at: http://www.bibalex.org
Category:

less

Transcript and Presenter's Notes

Title: Towards%20an%20Integrated%20Research%20Policy%20in%20the%20Area%20of%20Drug%20Discovery%20in%20the%20Arab%20Countries


1
Towards an Integrated Research Policy in the Area
of Drug Discovery in the Arab Countries
Including mechanisms to better utilization of
their terrestrial and marine wealth. Bassem
El-Menshawi NEPAD Sci Technol Regional
Coordinator for Northern Africa, National
Research Centre, Cairo, Egypt
2
DRUG DISCOVERY TYPES OF RESEARCH
LABORATORIES NEEDED This depends on the
therapeutic class required
3
DRUGS TO BE DISCOVERED FOR EXAMPLE IF
PRIORITY GIVEN TO -ANTITUMORS,
-ANTICARCINOGENIC, -IMMUNOMODULATORY,
-ANTIVIRAL AGENTS A CELL CULTURE LAB
IS NEEDED
4
  • THE STATE OF THE ART OF DRUG DISCOVERY
  • THE USE OF IN VITRO BIOASSAYS
  • THE USE OF CELL LINES
  • (e.g. HUMAN TUMOR CELL LINES)

ADVANTAGES AND DISADVANTAGES
In-Vitro Bioassays-Rapid, less
selective, but diagnostic, less expensive,
-suitable for minute amounts of materials,
-suitable for screening large number of
samples in Drug Discovery programs.
In-Vivo Bioassays More selective,
expensive, mostly Time Consuming,Animal model,
require large amounts of material,hardly could
guide the fractionation of extracts or mixture of
compounds.
5
  • TYPES OF RESOURCES TO BE UTILIZED
  • Natural Resources Line
  • - Plants
  • - Microbes (bacteria,
    fungi)
  • - Marine Organisms
  • Synthetic Line
  • - Novel Chemical Entities
  • - Generics

6
THE BASIC CHEMICAL LABS LAB FOR NATURAL
PRODUCTS (Isolation of Natural Compounds)

LAB FOR SYNTHESIS (Rational Pharmacological,
Computer Aided Drug Design)
7
IN ADDITION TO -
ANTI-VIRAL TESTING LAB - PHARMACOLOGICAL
PROFILE TOXICOLOGY LAB

8
FOR BIOTECHNOLOGICAL PRODUCTS A
BIOTECH / MOLECULAR BIOLOGY FOR
DISCOVERY OF ANTIBIOTICS A MICROBIOLOGY /
FERMENTATION LAB FOR ANTI-SCHISTOSOMIASIS
PARASITOLOGY LAB
9
THERAPEUTIC NATURAL PRODUCTS -
ACTIVE COMPOUNDS - ACTIVE EXTRACTS
- COMBINED ACTIVE EXTRACTS

10
METHODS OF DRUG DISCOVERY FROM NATURAL
PRODUCTSHow the Active Principle be identified
? -Phytochemical Approach
-Bio-Activity Approach -High Throughput
Screening -Computer Aided HPLC/MS
11
EXISTING PROJECT MODEL AT THE NATIONAL RESEARCH
CENTRE, EGYPT A SEARCH FOR
SCHISTOSOOMICIDAL, ANTITUMOR, ANTICARCINOGENIC,
IMMUNOMODULATORY, AND ANTIVIRAL AGENTS IN
EGYPTIAN PLANTS
12
  • This is a drug discovery program conducted at
    NRC
  • based on Egyptian plants,
  • utilizes universally accepted protocols
  • for bioactivity-guided fractionation
  • of plant extracts,
  • and in-Vitro Bioassays.

13
  • Under this project Egyptian plants
  • are Bio-assayed for specific
  • medicinal activities
  • Schistosomicidal
  • Antitumor
  • Cancer chemopreventive
  • anticarcinogenic
  • Immunomodulating
  • Antiviral

14
BIOACTIVITY APPROACH-Extracts are screened for
a specific medicinal activity (an in-vitro
bioassay).-Only BioActive extracts are
fractionated.-Active fractions are further
fractionated to isolate the active
compound(s) in pure form. -Characterization
of its structure.
15
  • Only Bio-Active Extracts
  • are subjected to
  • Bioassay-Guided Fractionation, in 2
  • steps
  • Initial Partitioning
  • Comprehensive Fractionation
  • for the isolation of their active
  • principles.

16
  • EX-VIVO BIOASSAY
  • In-Vivo / In-Vitro
  • Used for assaying the activity of compounds
    isolated in limited amounts,
  • untill additional materials could be obtained
    sufficient for in-vivo bioassy.
  • It detects the effect of in-vivo absorption and
    metabolism on compounds that are active
    in-vitro.

17
  • Active compounds isolated are then bioassayed
    in animal models
  • to confirm the bioactivity
  • and determine their therapeutic value and
    toxicity profiles.

18
The overall accomplishments After 3 years of the
projects life are as follows
19
(No Transcript)
20
(No Transcript)
21
(No Transcript)
22
(No Transcript)
23
(No Transcript)
24
(No Transcript)
25
(No Transcript)
26
(No Transcript)
27
Conclusions-Screening Large Number of
Natural Species-Using In Vitro Bioassays-For
5-10 Medicinal Activities
28
  • Conclusions-Integrates Arab Natural
    wealth-Optimizes Arab IPR-Enhance the
    Invention in a Strategic Area

29
Conclusions- 1-3 Central Joint Research Lab
(under one strategy, one mechanism, one protocol,
and one leader).- Nodes in each country- Joint
Surveying of Biodiversity-Joint Ownership of
Products- Networking
30
Conclusions- Arab Meeting for Strategic
Planning of Drug Discovery- Role of Bibliotheca
Alexandrina
31
ALL THE PRAISES AND THANKS BE TO ALLAH
32
(No Transcript)
33
  • THIS PROJECT IS FUNDED BY THE ACADEMY OF
    SCIENTIFIC RESEARCH AND TECHNOLOGY, CAIRO, EGYPT,
    UNDER THE PROGRAM OF BIOTECHNOLOGY 1998.
Write a Comment
User Comments (0)
About PowerShow.com