RESOURCE DESCRIPTION FRAMEWORK FOR DERMATOPATHOLOGY' http:www'netautopsy'orgdermrdfh'htm http:www'ne

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RESOURCE DESCRIPTION FRAMEWORK FOR
DERMATOPATHOLOGY.http//www.netautopsy.org/dermrd
fh.htmhttp//www.netautopsy.org/dermrdfh.ppt
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G. William Moore, MD, PhD.1,2,3 Grace F. Kao,
MD.1,4 Lawrence A. Brown, MD.1,2

• 1. Pathology and Laboratory Medicine Service,
  Veterans Affairs Maryland Health Care System,
  Baltimore, MD 1.
• 2. Department of Pathology, University of
  Maryland Medical System, Baltimore, MD.
• 3. Department of Pathology, The Johns Hopkins
  Medical Institutions, Baltimore, MD.
• 4. Department of Dermatology, George Washington
  University School of Medicine, Washington, DC.

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Resource Description Framework (RDF)

• General syntax for writing ordered triples.
• Computer-parsable.
• Binding a described datum to a specified subject.
  
• Internet web-crawler programs draw inferences
  from ordered triples.

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Ordered Triples on RDF.

• Sample Ordered Triple ltbill_moore,cancer,yesgt.
• Detailed sample ordered Triple
  ltbill_moore,squamous_cell_carcinoma_arising_in_hyp
  ertrophic_actinic_keratosis_right_dorsal_wrist,yes
  gt.
• Ordered Triple ltsubject,metadatum,datumgt.

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RDF CLASSES/PROPERTIES.

• RDF CLASS Strict monoparental hierarchy of
  classes.
• Classes are mathematically consistent.
• RDF PROPERTY Multiple parents possible.
• Weaker mathematical properties.
• Should be avoided if possible.

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RDF HIERARCHY FOR SKIN.

• anypatient
• -tissue
• tissue
• -skin
• skin
• -skin_reaction
• skin_reaction
• interface_dermatitis
• lichenoid_dermatitis
• dense_bandlike_superficial_de
  rmal_infiltrate

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Lichenoid Dermatitis Common.

• Dense, band-like upper dermal inflammation.
• Lichen_planus.
• Lichenoid_benign_keratosis.
• Lichen_simplex_chronicus.
• Lichenoid_actinic_keratosisrare_but_important.
• Mycosis_fungoidesrare_but_important.
• Lupus_erythematosusrare_but_important.

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Lichenoid dermatitis Lichen Planus

• Dense upper dermal band-like infiltrate.
• Saw-tooth rete ridges.
• Civatte bodies.

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Lichenoid dermatitis Lichenoid arthropod
bite.

• Crops of lesions.
• Ulcers come and go.
• Necrosis.
• Scale crust.
• Perivascular chronic inflammation with increased
  eosinophils.
• No basal layer atypia

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Lichenoid dermatitis Lichen
simplex chronicus

• Psoriasiform acanthosis.
• Hypergranulosis.
• Parakeratosis.
• No basal layer atypia.

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Lichenoid dermatitis Lichenoid
actinic keratosis.

• Uncommon but important.
• Usually sparse upper dermal infiltrate.
• Basal layer atypia.
• Precursor of invasive squamous cell carcinoma.

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Lichenoid dermatitis Mycosis fungoides

• Rare but important
• Usually sparse upper dermal infiltrate.
• Small and medium T-cells involving epidermis.
• Pautriers microabscess.
• Cutaneous lymphoma.

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Namespace

• Strict hierarchy of all concepts in the ontology.
  
• Each name appears exactly once.
• Each name has exactly one parent.
• Ultimate name has no parent.
• Negations not allowed.
• Namespace formalism is consistent.

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Relationspace/Fuzzyspace.

• Relationspace List of all relationships among
  concepts.
• Includes concepts with negations and multiple
  parents.
• Fuzzyspace Levels of certainty within the same
  concept.
• Based upon fuzzy set theory.
• May be necessary to take actions based upon
  incomplete information.

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Theorems of Relationspace.

• Theorem 1. Consistency of Namespace.
• Theorem 2. Identity.
• Theorem 3. Or-expansion.
• Theorem 4. Telescoping.
• Theorem 5. Contextualization.
• Theorem 6. Intercalation.
• Theorem 7. Retirement.

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Results

• Mathematical consistency.
• 200 theorems of classical and modal logic.
• Intercalation Theorem (inserting new concepts).
• Retirement Theorem (removing obsolete concepts).

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Conclusions

• Organize knowledge of dermatopathology.
• Format of the semantic worldwide web.
• Incorporates clinical and pathologic findings.
• Possible target language for computer translation
  of medical narratives.