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Bioinstrumentation Curriculum Workshop Whitaker Foundation Biomedical Engineering Educational Summit December 9, 2000


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Title: Bioinstrumentation Curriculum Workshop Whitaker Foundation Biomedical Engineering Educational Summit December 9, 2000

Bioinstrumentation Curriculum Workshop
Whitaker Foundation Biomedical Engineering
Educational SummitDecember 9, 2000
  • Rebecca Richards-Kortum, PhD
  • The University of Texas at Austin
  • John G. Webster, PhD
  • The University of Wisconsin

Goals Bioinstrumentation Curriculum
  • Discuss and Generate Consensus Report
  • Current Status and Best Practices
  • Critical Incoming Knowledge Base Needed
  • Role of Experiential Learning
  • Intellectual Trends for the Future
  • Recommendations for Future Curriculum

Whitaker Foundation Philosophy
  • A thorough understanding of life sciences, with
    life sciences a critical component of the
  • 2. Mastery of advanced engineering
  • 3. Familiarity with problems of making and
    interpreting quantitative measurements in living
  • 4. The ability to use modeling techniques as a
    tool for integrating knowledge.
  • 5. The ability to formulate and solve problems
    with medical relevance, including the design of
    devices, systems, and processes to improve human

Current Status Courses at Top 12 Institutions
Current Status
Institution Required Courses Year Taken Pre-Requisites
UCSD Principles of Bio-inst. Design Biomedical Electronics Junior   Senior Linear Circuits, Exptl. Techs. Biosystems and Control, Princ. of Bioinst. Design
Duke University Biomedical Electronics and Measurements I Biomedical Electronics and Measurements II Soph.   Junior Introduction to Electric Circuits Biomedical Electronics and Measurements I
Current Status
Institution Required Courses Year Taken Pre-Requisites
Case Western Reserve Principles of Biomedical Instrum.   BME Instrumentation Lab Biomedical Engineering Lab I Junior     Junior Junior Physiol./Biophys. I/II, Circuits, Signals/Sys. I Principles of Biomedical Instrum. Physiol./Biophys. I/II, Circuits, Signals/Sys. I
Univ. of Penn. Bioengineering Laboratory I Bioengineering Laboratory IV Soph. Junior 1 year of calculus, physics Bioengineering Lab III
Current Status
Institution Required Courses Year Taken Pre-Requisites
Johns Hopkins None
UCBerkeley None
Rice None
Northwestern None
Current Status Review of Syllabi
Institution Course
UCSD BE186B Principles of Bio-inst. Design
UCSD BE122B Biomedical Electronics
Duke BME163L Biomed. Elec./Measurements I
Duke BME164L Biomed. Elec./Measurements II
CWRU EBME310 Principles of Biomedical Inst.
CWRU EBME313 Biomedical Eng. Lab I
CWRU EBME360 BME Instrumentation Lab
Penn BE209 Bioengineering Laboratory I
Penn BE 310 Bioengineering Laboratory IV
CWRU EBME310 Biomedical Instrum.
  • Topics
  • Biopotential Electrodes
  • Electrochemical Transducers of Biochemical
  • Temperature Transducers
  • Measuring Flow
  • Mechanical Transducers
  • Optical Sensing
  • Imaging in Single Cells
  • Single Cell Electrophysiological Measurements
  • Piezoelectric Transducers and Instruments
  • Analytical Instruments for Biomaterials Research

CWRU EBME360 Biomedical Instrum. Lab
  • Topics
  • Body Surface Electrochemistry
  • Multi-electrode ECG
  • EMG Transduction
  • LED pulse Plethysmograph Circuit
  • Patch Lamp Technique
  • Ultrasound Image Formation

  • Topics
  • Errors and Error Analysis
  • Ethics
  • Computer Presentation
  • Lab (63 of grade) choose three from
  • 3D landmark coordinates from bi-orthogonal film
  • Ultrasound measurements of flow
  • Measuring neurotransmitters with microelectrode
  • Quantitative Properties of the Neuromuscular
  • Evaluation of bone/implant interface using
  • Patch clamp recording from retinal cells
  • Measurement of blood flow using PET
  • Compare mammographic image registration algos
  • Measuring the compliance of heart valves

UCSD BE122B Biomedical Electronics
  • Topics
  • Analog to Digital Conversion
  • Digital Ckt Building Blocks
  • Convolution
  • Sampling Theorem
  • Fourier Transforms
  • Image Processing
  • Ultrasound
  • Computed Tomography
  • Electrokinetic Phenomena
  • Lab No
  • Project 25

UCSD BE 186B Principles of Bioinst. Design
  • Topics
  • Biopotentials
  • Electronics Review
  • Amplifiers
  • Electrical Safety
  • Biopotential Electrodes
  • Chemical Sensors
  • Light Based Instrumentation
  • Video Systems
  • Flow Measurements
  • Ultrasound
  • Lab No
  • Project No

Duke 163L BME Elec. and Meas. I
  • Topics

Duke BME164L BME Elec. and Meas. II
  • Topics
  • Transducers and Sensors
  • Op Amps, Filter, Differential and Instrument
  • Digital Devices and Circuits
  • Recording and Display Devices
  • Fourier Transforms, Series and Sampling
  • Lab (20 of grade)
  • Project (50 of grade)
  • Sensor, signal processing unit, A/D converter,

Penn BE209 Bioengineering Lab I
  • Topics
  • Biomedical Electronics
  • Mechanical Testing of Biological Specimens
  • Lab (50 of grade)
  • Electronic thermometer
  • Building the electronic scale
  • Building the electronic exercise evaluation
  • Building the electronic signal generator
  • Uniaxial Load testing of biological specimens
  • Tensile properties of chicken skin
  • Three point bending of chicken bones
  • Impact strength of chicken bone
  • Uses Discovery Learning

Penn BE310 Bioengineering Lab IV
  • Topics
  • Fluid Mechanics
  • Signal Analysis
  • Lab
  • Fluid Mechanical Simulation of Coughing
  • Measurement of Pressure and Flow in Straight Tube
  • Steady Flow through a Sacular Aneurysm Model
  • Conservation of Energy - Thermodilution
  • Signal Analysis The Electrocardiogram
  • Signal analysis Vibration Analysis
  • Project
  • Several weeks duration

Wisconsin BME310 Bioinstrumentation
  • Topics
  • Measurement systems
  • Signal Processing
  • Molecules in Clinical Chemistry
  • Mol. Measurements in Biomaterials and Tissue Eng.
  • Hematology
  • Cell. Measurements in Biomaterials and Tissue
  • Nervous System, Heart and Circulation, Lungs,
    Kidney, Bone and Skin
  • Labs (20 of grade)
  • 1. Blood Pressure, 2. Circuits, 3. Pressure
    Sensor, 4. Pulse Oximeter, 5. ECG, 6. Ultrasonic
    Flowmeter, 7. Spirometery, 8. Temperature, 9.
    Spectrophotometer, 10. Electrophoresis, 11.
    Dynamic Light Scattering, 12. Microscopes

UT EE374k Biomedical Instrumentation
  • Topics
  • Transducers
  • Light sources, Photodetectors
  • Signal conditioning and amplification
  • Biopotentials
  • EMG, ECG
  • Electrodes
  • Microeelctrodes
  • Blood Pressure
  • Flow
  • Ultrasound
  • Pacemakers, Defribrillators
  • Electrical Safety

Comparison of Courses
Comparison of Courses
Current Status Exercise Number One
  • Introductions
  • Describe Bioinstrumentation Curriculum at Your

Best Practices
  • Issues to Consider
  • Course Subject Matter
  • General Course Outcomes
  • Specific Course Learning Objectives
  • Course Outline
  • Prerequisites
  • Course Level
  • Textbooks
  • Laboratories

Best Practices Industrial Survey
  • Please list the 5 most important technical topics
    that a BME who graduates with a BS in the next
    5-10 years will need to know.
  • 1. PSI, 2. Sulzer Carbomedics, 3. Sulzer
    Biologics, 4. Sulzer Orthopedics, 5. Sulzer
    Carbomedics, 6. GE, 7. Zeiss

Company Top 5 Skills
1 DSP Analog ckts, electronics Chemistry (thru Organic) Programming/ Software design Basic biology/human physiology
2 Blood-mat. inter. Bio-compat. Experiment Design Eng. Prop. of Materials Tissue Engineering
3 Delivery of agents Molecular biology Tissue Const.
4 One eng. field well
5 Protein ads. cell interac. Prin. of tissue eng. Molecular biology Intro. to Med. Indus. Report writing, technical pres.
6 Imaging Technologies Molecular Function Informatics Statistical Analysis Pharmacology
7 Good found. in physics Matls. Sci. and combo chem Inter-, intra-cell. Proc. Gene, protein func. Molecular Biology
Course Subject Matter Overall Goal
  • Prepare students to design and utilize biomedical
    instrumentation for measurements on humans and
  • Sensors
  • Diagnostic Devices
  • Therapeutic Devices
  • New Fields Molecular engineering, cell and
    tissue engineering, biotechnology

General Course Outcomes
  • Recall bioinstrumentation vocabulary
  • Analyze measurement specifications
  • Choose the best method of making a measurement of
    performing therapy
  • Perform open-ended design of a measurement or
    therapeutic device
  • Analyze data resulting from a measurement of
    therapeutic device
  • Search internet, medical, engineering and patent
  • Communicate effectively
  • Pass nationally-normed subject content exams

Specific Course Learning Objectives
  • Behaviorally observable objectives that
    illustrate concepts, relationships and skills to
    be gained
  • Examples
  • Draw circuit / amplifier design for a pO2
  • Draw block diagrams for A-mode, B-mode and T-M
    ultrasonic image scanners
  • Design grounding system for an ICU
  • Explain how DNA is automatically sequenced and
    and how fluorescence assists signal processing

Course Outline Exercise 2
  • Rank the ten most important topics to cover

Specific Course Learning Objectives

  • Should include
  • One year of calculus and physics
  • One semester of chemistry
  • Differential equations
  • Cell and molecular biology
  • Electric circuits
  • Electronics
  • Background in programming, statistics, signal

Course Level
  • Junior year

Author/Editor Title Comments
Webster, J. G. (ed.) Medical instrumentation application and design, 3rd. ed systems, sensors, circuits, hospital instrumentation, therapeutic devices, safety, but omits the new fields.
Togawa, T., T. Tamura, P. A. Oberg Biomedical transducers and instruments short descriptions of very many biomedical transducers, but omits the new fields
Northrop, R.B. Introduction to instrument. and measurements physical sensors, electrical measurements, digital interfaces and signal conditioning, but lacks biomedical instrumentation
Welkowitz, W., S, Deutsch, M. Akay Biomedical instruments theory and design, 2nd. ed. physical sensors, analog and digital circuits, 12 biomedical instrumentation designs, medical imaging.
Author/Editor Title Comments
Aston, R. Principles of biomedical instrumentation and measurement descriptive, lacks equations, and omits the new fields
Geddes, L. A. and L. E. Baker Principles of applied biomedical instrumentation, 3rd many sensors for biomedicine, therapeutic devices, but omits the new fields
Normann, R. A. Principles of bioinstrumentation circuits, sensors for biomedicine, computers, signal processing, safety, but omit the new fields
Bronzino, J. D. Biomedical engineering and instrumentation many sensors for biomedicine, therapeutic devices, but omits the new fields
Author/Editor Title Comments
Cromwell, L., F. J. Weibell, E. A. Pfeiffer Biomedical instrumentation and measurements, 2nd ed descriptive lacks equations, and omits the new fields
Cobbold, R. S. C. Transducers for biomedical measurements systems, many sensors for biomedicine, but omits the new fields
Webster, J. G. (ed.), Bioinstrumentation introduces 4th semester student to measurements. Covers necessary electronics, then measurements in the new fields of molecular engineering, cellular engineering, tissue engineering, biotechnology plus hospital instrumentation. No therapy.
Role of Experiential Learning
  • Knowledge taught in a single context is less
    likely to support flexible transfer of knowledge.
  • Laboratory modules
  • Develop intuition and deepen understanding of
  • Apply concepts learned in class to new situations
  • Experience basic phenomena
  • Develop critical, quantitative thinking
  • Develop experimental and data analysis skills
  • Learn to use scientific apparatus
  • Learn to estimate statistical errors, recognize
    systematic errors
  • Develop reporting skills

Science Teaching Reconsidered A Handbook
National Research Council
  • Exercise 3 Rank the top 5 most important
    laboratory experiences


Role of Technology in Learning
  • Bring real world problems into classrooms
  • Provide scaffolding to augment what learners can
    do and reason about on their path to
  • Increase opportunities for learners to receive
    feedback to reflect on their learning process
    to receive guidance toward progressive revisions
    that improve learning
  • Build local, global communities of teachers and
  • Expand opportunities for teacher learning

Bransford et al How People Learn
Web Based Instructional Materials
  • http//
  • http//
  • http//

  • NSF ERC Bioengineering Educational Tech.
  • Modular, multimedia learning tools
  • Collaboration of bioengineering educators and
    learning scientists
  • 10 Million over 5 years
Recommendations for Future Curriculum
  • Past emphasized measurements in traditional
    areas such as biomedical instrumentation and
  • Future Expand these areas to include
    measurements in biosensors, molecular, cell and
    tissue engineering and biotechnology

The UT Electronic Taste Chip
salts, sugars, acids, alkaloids, small molecules,
proteins, antibodies, DNA, redox species, solvents
John T. McDevitt / UT Chem. Biochem. Dept.
The Bead Array Chip
Mass Production of Customized Chips
106 Beads per Gram
John T. McDevitt / UT Chem. Biochem. Dept.
Science Demonstration 1
Ca(2) Flow Dynamics Visualized (OCP Beads)
John T. McDevitt / UT Chem. Biochem. Dept.
Science Demonstration 4
Beads conjugated to monoclonal antibody to HIV p24
Blank control beads
John T. McDevitt / UT Chem. Biochem. Dept.
Areas for the Future Exercise 5
  • What new areas of bioinstrumentation will be
    important to emphasize in the next 5 10 years?

Questions for Discussion
  • Should all BME students take a bioinstrumentation

Questions for Discussion
  • What role can technology-enhanced learning play
    in bioinstrumentation courses and laboratories?