Pathology of Breast Cancer

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Pathology of Breast Cancer

• Dr. Venkatesh M. Shashidhar
• Senior Lecturer in Pathology
• Fiji School of Medicine

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No doubt knowledge is valuable..,But above
it are power, goodness most important Character
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Normal Breast
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Normal Breast lobule (ipx)
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Introduction

• Female breasts are modified sweat glands.
• Lobes and lobules in adipose tissue stroma.
• Lactiferous ducts merge just beneath the nipple
  to form a lactiferous sinus.
• Majority of cancers arise in the ducts.
• Breast cancer is very rare before age 25
• 1 in 8 women in US develop breast cancer
• Less incidence in Asia

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Histological Types
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Breast Carcinoma
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Breast Carcinoma - Schirrous
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Infiltrating Duct Carcinoma
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Infiltrating Duct Carcinoma
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Schirrous Carcinoma
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Medullary CarcinomaSoft, inflammatory cells
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Colloid Carcinoma
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Intraductal in-situ Carcinoma
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Lobular Carcinoma
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Intraduct Carcinoma
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Lymphatic spread in Breast Ca
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Intraduct Carcinoma
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Pagets Disease (Epidermal invasion)
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Risk Factors

• Maternal relative with breast cancer.
• BRCA1 and BRCA2 genes
• Longer reproductive span.
• Obesity.
• Nulliparity.
• Later age at first pregnancy.
• Atypical epithelial hyperplasia.
• Previous breast cancer/Endometrial Ca.

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Estrogen receptor (ER) in nuclei will have a
better prognosis (Tamoxifen)
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C-erb Positivity IPXHigh grade, Aneuploidy
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Immunoperoxidase Positivity
Neg 1 2 3
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Tumor - DNA Analysis
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Thank You
Dr. Venkatesh M. Shashidhar Senior Lecturer in
Pathology Fiji School of Medicine