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CSREES Animal Protection Portfolio: The Last 5 Years

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Title: CSREES Animal Protection Portfolio: The Last 5 Years


1
CSREES Animal Protection Portfolio The Last 5
Years Recent Program Review Gary Sherman,
National Program Leader (Veterinary
Science) Peter Johnson, National Program Leader
(Animal Health)
2
CSREES Animal Health Veterinary Medicine
National Program Leaders
CSREES Animal Health Veterinary Medicine
National Program Leaders
3
Whats to come…
  • What is CSREES role in Animal Health ?
  • What does the portfolio look like ?
  • What has it accomplished ?

4
CSREES Animal Systems Vision
  • A vibrant, globally competitive,
    technologically advanced, and consumer driven
    American animal agriculture industry that is
    based on and supported by high quality,
    innovative, and relevant research, extension and
    educational programs provided by USDA through
    partnerships with universities and the private
    sector, as well as the in-house research programs
    of the Department.

5
CSREES 5 Unique Roles
  • Support college/university/diagnostic laboratory
    infrastructure provide land-grant institutions
    veterinary colleges/departments of veterinary
    science small-scale animal protection research
    funds (Formula Funds cooperative agreements)
  • Solicit basic applied research, education, and
    extension proposals from all U.S. institution
    types, including Federal laboratories and private
    industry and support the best science and
    training through competitive peer review and
    larger awards (Competitive Funds)

6
CSREES 5 Unique Roles
  • Stimulate interstate cooperation for targeted
    animal diseases and well-being through multistate
    committees multimillion dollar Coordinated
    Agricultural Project (CAP) competitive awards
    (Formula Funds and Competitive Funds)
  • Focus funds on targeted diseases and national
    programs of state and regional importance
    (Special Grants and Critical Issues Funds)
  • Serve as the federal link to the veterinary
    extension and education infrastructure to
    disseminate timely and pertinent animal health
    information (Formula Funds)

7
Whats to come…
  • What is CSREES role in Animal Health ?
  • What does the portfolio look like ?
  • What has it accomplished ?

8
Animal Protection Research Funding (CSREES) M
9
Investment (1999-2003)
  • 75 invested in infectious non-infectious
    diseases
  • Emerging, re-emerging, high impact diseases such
    as TB, Brucellosis, FMD, Bovine Respiratory
    Disease Complex, Mastitis, BVD, Johnes, E. coli,
    BT, Influenza, END, Mareks Disease, Avian
    leukosis, PEMS, PRRS, PMWS, Salmonella,
    Mycoplasma, WNV, Rhodococcus equi, Laminitis,
    TSEs , etc.

10
Investment (1999-2003)
  • 10 on internal external parasites Such as
    Cryptosporidium, Toxoplasma, Nematodes-
    Haemonchus, Ticks, Biting Flies, Lice…
  • 5 on naturally occurring toxins (e.g.,
    mycotoxins), poisonous plants, toxic chemicals
  • 10 Animal Well-being/ behavior

11
Animal Health Scope
Diverse Commodities
  • Poultry
  • Beef Dairy Cattle
  • Swine
  • Sheep
  • Goats
  • Farmed aquatic species,
  • Horses
  • Wildlife (impacting livestock)

12
Animal Health Scope
  • Science Balance
  • Bacteriology, virology, immunology, parasitology,
    epidemiology, economics, toxicology, behavior,
    ethics, education, physiology, pathology,
    mycology, pharmacology, nutrition, biochemistry,
    statistics, engineering…
  • Basic (molecular cellular biology/genomics)
    applied (field studies/ educational outreach
    programs)
  • Individual multi-disciplinary approaches
  • Single multi-institutional/states

13
CSREES Partners
  • All institutions of higher education with animal
    programs
  • Commodity industry groups
  • Other Federal, State, and Local agencies
  • Professional organizations
  • Consumer organizations

14
Strong Partnership with ARS
  • Frequent email / Calls / Meetings (MD/DC)
  • Participation in each others workshops
  • ARS Vet Immunology Workshop (2003) ? Critical
    lack of veterinary reagents ? ARS/CSREES/AAVI ?
    CSREES uses competitive programs to request Vet
    Immunological Reagent consortia proposal ?
    ARS/APHIS/CSREES/AAVI ? Now a recommendation to
    support a proposal.
  • Joint ARS/CSREES workshops
  • 2001 - ARS CSREES reported back how working
    together for animal Ag
  • This workshop! (2005)

15
Alignment with ARS priorities
  • Pathogen Detection and Diagnostics
  • Animal Immunology
  • Microbial Genomics
  • Mechanism of Disease
  • Genetic Resistance to Disease
  • Epidemiology of Disease
  • Strategies to Control Infectious and
    Non-Infectious Disease 

16
Alignment with APHIS priorities
CSREES projects in APHIS 2005 research
priorities
  • Tuberculosis
  • Brucellosis
  • Bluetongue
  • TSEs (CWD, Scrapie, BSE)
  • Johne's Disease
  • Spring Viremia of Carp
  • Infectious Salmon Anemia
  • Equine Piroplasmosis
  • Newcastle Disease Virus
  • Classical Swine Fever
  • PRRS
  • PMWS
  • Swine Influenza
  • Salmonellosis
  • Avian Influenza
  • Avian Pneumovirus
  • Antimicrobials
  • Pseudorabies
  • FMD
  • Ticks

17
Alignment with APHIS priorities
  • APHIS Animal Identification Plan
  • CSREES part of National Animal Identification
    Development Team (State-Federal-Industry)
  • Participate in developing RFAs for Cooperative
    Service Agreements (11.6M FY 2004 APHIS )
  • Executive Summary and national brochure
    development

18
Other CSREES Federal Alliances
  • Agriculture Multi-Agency Coordinating (AgMAC)
    Committee for END
  • Inter-Departmental Committee to Develop National
    CWD Management Plan
  • Federal Inter-Agency Working Group on Prion
    Science
  • White House Committee on Science, National
    Science and Technology Council
  • 11 participating federal agencies

19
National Animal Plant Diagnostic Laboratory
Networks
20
NAHLN
  • Mission
  • Provides accessible, timely, accurate, and
    consistent animal disease laboratory services
    nationwide
  • Provides laboratory data to meet epidemiological
    and disease reporting needs
  • Maintains the capacity and capability to provide
    laboratory services in support of early diagnosis
    and response to foreign animal disease outbreaks
    or other adverse animal health events (including
    bioterrorism events).
  • Focuses on diseases of livestock (including
    exotic, zoonotic, and emerging diseases), but
    includes diseases of all animals

21
NAHLN Operational Objectives
  • Standardized, rapid diagnostic techniques
  • Secure communication, alert, reporting system
  • Trained personnel, modern equipment
  • Quality standards, proficiency testing
  • Adequate facility biosafety/biosecurity levels
  • Surge capacity
  • Scenario testing

22
Founding Laboratories 2002-2003
DECEMBER 2004
MARCH 2005
SEPTEMBER 2005
23
(No Transcript)
24
Targeted Coordination
  • 12 Multi-state research projects
  • Control of emerging re-emerging poultry
    respiratory diseases in the US
  • Evolving pathogens, targeted sequences,
    strategies for control of bovine respiratory
    diseases
  • Enteric diseases of swine cattle prevention,
    control food safety
  • Porcine reproductive respiratory syndrome
    (PRRS) Mechanisms of disease methods for the
    detection, protection, elimination of PRRS
    virus

25
Targeted Coordination
  • 12 Multi-state research projects
  • 5. Genetic basis for resistance immunity to
    avian diseases
  • Mastitis resistance to enhance dairy food safety
  • Genetic functional genomic approaches to
    improve production quality of pork
  • Management systems to improve the economic
    environmental sustainability of dairy
    enterprises

26
Targeted Coordination
  • 12 Multi-state research projects
  • Integrated methods of parasite control for
    improved livestock production
  • Water Quality issues in poultry production
    processing
  • Mycotoxins in cereal grains
  • Animal health advisory committee

27
Whats to come…
  • What is CSREES role in Animal Health ?
  • What does the portfolio look like ?
  • What has it accomplished ?

28
Impacts on Multiple Levels
  • Research funding fills key knowledge gaps
    (pathogen biology, host-pathogen interactions,
    immunology, non-infectious disease etiology and
    control, epidemiology and ecology)
  • Products
  • peer reviewed publications
  • patents, licenses
  • vaccines, diagnostics, treatments
  • policy development
  • open the way for the piloting of new management
    strategies.

29
Impacts on Multiple Levels
  • Education programs support the training of the
    next generation's animal health workforce.
  • Products
  • New curricula materials
  • (including instruction delivery systems that
    address diverse student learning
    abilities)
  • Training
  • (undergraduates, graduates postdoctoral
    fellows through Fellowships Scholarships)
  • Experiential learning opportunities for
    veterinary students
  • (gain exposure to laboratory settings high
  • need areas such as food animal practice)

30
Impacts on Multiple Levels
  • Extension programs rapid wide-spread
    dissemination of research results other high
    impact information to implement new management
    strategies or respond to crisis
  • Products
  • Referred publications, lay articles
  • Websites
  • training courses
  • presentations at conferences and meetings
  • identification of research gaps
  • emergency outreach response

31
Impacts
  • National Animal Health Laboratory Network
  • Training diagnostic personnel to improve service
    capabilities
  • Expanding standardized rapid/sensitive testing
    capabilities
  • Improving the nations Bio-Safety Level (BSL)-3
    capability
  • Assuring quality standards and proficiency
    testing
  • Improving communications to share data
  • 12 pilot laboratories and 32 other laboratories
    funded by APHIS, provide surveillance testing in
    37 states for
  • Bovine Spongiform Encephalopathy
  • Exotic Newcastle Disease
  • Highly Pathogenic Avian Influenza
  • Chronic Wasting Disease

32
Impact
  • NEW product to detect EARLY lameness in cattle,
    incl. limb (Lameness Detection Technology patent
    UMD UDE) undergoing field testing on commercial
    dairy farms in WI and PA by Bou-Matic, LLC

33
Impact
  • NEW vaccine developed for Staphylococcal mastitis
    using detoxified toxin
  • (UID, WSU, Seoul NU)
  • US patent LG Life Sci. Ltd. Licensed (2004)
  • Antigen expressed in edible vaccines (patent
    pending)
  • NIH collaborators using technology for conjugate
  • vaccines for human meningitis

34
CSU PIADC Foot Mouth Disease in North
American Wildlife Susceptibility, transmission,
carrier/shedder potential mitigation strategies
35
Impact
  • NEW diagnostic for swine influenza A viruses
    (UWI)
  • Use of real-time reverse transcriptase
    polymerase chain reaction assay and cell culture
    methods for detection of swine influenza A
    viruses (AJVR Vol. 66, No. 1, 2005, 119-124)

36
Impact
NEW management recommendation (NCSU)
  • Equine intestinal repair research showed
    inhibition of prostaglandin production (by drugs
    such as flunixin meglumine) impairs repair
  • Veterinarians advised use non-steroidal
    anti-Inflammatory drugs cautiously in horses with
    intestinal injury until safer alternative
  • Practical Horseman, Equus, The Horse

37
Impact
REVISED OIE Sanitary Code for Bluetongue (1998/99)
  • BT research at UC-Davis
  • Helped justify 3rd International Bluetongue
    Symposium (2003)
  • Symposium conclusions basis for proposed
    revisions to current OIE Sanitary Code

38
Impact
EXCITING MDV mutant with potential as new
generation vaccine (UDE)
  • Using genomics to study Mareks Disease
  • MDV latency associated transcripts (LATs)
    identified
  • Herpes virus of turkeys LATS identified and
    compared to LATs of MDV
  • MDV mutant with defective LAT promoter isolated
    and found to be NONoncogenic

39
Impact
Microbial Genome Sequencing 18
pathogens ( 6.7M)
  • Actinobacillus pleuropneumoniae (University of
    Oklahoma Health Sciences Center)
  • Anaplasma marginale (Washington State University
    ARS)
  • Bordetella avium (Drew University/ Sanger Center,
    UK)
  • Dichelobacter nodosus (University of Arizona)
  • Edwardsiella ictaluri (Mississippi State
    University)
  • Hemophilus somnus (Virginia Polytechnic Institute
    and State University)
  • Lawsonia intracellularis (University of
    Minnesota)
  • Mannheimia haemolytica (Baylor College of
    Medicine)
  • Moraxella bovis (Baylor College of Medicine)
  • Mycobacterium avium subspecies paratuberculosis
    (University of Minnesota ARS)
  • Neospora caninum- Expressed Sequence Tags (ESTs)
    only (University of Washington)
  • Pasteurella multocida- non-toxigenic swine
    isolate (University of Oklahoma Health Sciences
    Center)
  • Pasteurella multocida- turkey strain (University
    of Minnesota Minnesota Turkey Growers
    Association)
  • Renibacterium salmoninarum (Northwest Fisheries
    Science Center, NOAA)
  • Salmonella dublin Salmonella choleraesuis
    Salmonella pullorum (University of Illinois)
  • Staphylococcus aureus- dairy mastitis strain
    (University of Minnesota NIH)

40
Impact
  • SIGNIFICANT Training of graduate postdoctoral
    students (including new industry recruits)
  • Competitive programs supported 236 students
    in animal health (1999-2003)
  • Experiential learning programs for veterinary
    students in research labs, food animal medicine
    (Cornell, KSU/SDSU, UMN…)

41
Impact
  • NEW Curriculum
  • Internet based Problem List Generator for
    diagnostic problem solving skills for pathology
    students (www.fdi.vt.edu/plg) (VPISU…ISU,UWI,UC-Da
    vis…)
  • Exotic Emerging Diseases of Animals An
    Internet Course for Veterinary Students
    (ISUUC-DavisUGA)

42
Impact
  • Bioterrorism Awareness Education Zoonotic Disease
    Training for Veterinarians (ISU) (2002 2003)
  • Training for all extension veterinarians and all
    50 state associations
  • EDEN (Ext. Disaster Ed. Network) established in
    1995 (www.eden.lsu.edu)
  • Access to all 3150 US counties, connected to
    veterinary extension

43
Impacts
  • Bovine Respiratory Disease Multi-State Research
    Committee
  • Presented entire 2 ½ day symposium to Academy of
    Veterinary Consultants
  • Applied Bovine Reproductive Strategies
    Multi-State Extension Committee
  • 2 sessions 260 producers technology impact on
    more than 3.5M US beef cattle
  • Part of 2005 NCBA Cattlemens College
  • Also incorporated biosecurity animal ID

44
NEW DIRECTIONS
Why your input at this workshop is very important…
45
Tighter Focus of Agency Resources
  • Focusing competitive funds into fewer animal
    health priority areas
  • Input requested from gt60 organizations (profession
    al associations, scientific colleges, trade
    commodity, federal, state partners)
    Re-evaluated annually
  • Some areas/diseases EXCLUDED

46
NRI Animal Protection Program
  • 3 diseases/commodity (swine poultry
    aquaculture equine)
  • 4 diseases for ruminants
  • FADs
  • Livestock-wildlife interface
  • Immunology (non-disease specific)

47
Animal Biosecurity Program
  • 4M annual budget from CSREES-NRI
  • Coordinated Agricultural Project (CAP) for
    specific problem or issue
  • Multi-institutional / Multi-disciplinary
  • Research, education, extension
  • International

48
Coordinated Agricultural Projects
  • Community Products
  • Roadmaps including gap analysis
  • Standardized protocols
  • (e.g., diagnostics, vaccine trials, genetic
    resistance studies)
  • Sample Repositories databases
  • Genomics/proteomics tools services (e.g.,
    mutants arrays clone sets immunological
    typing bioinformatics)
  • Extension communication programs (e.g.,
    training tools, demonstrations, conferences, CE,
    publications, websites)

49
Coordinated Agricultural Projects
  • Leverage, Coordinate Partner project resources
    with other initiatives in Academia, Industry,
    Federal State Agencies, Other Countries
  • Fill critical knowledge gaps (pathogen biology
    host/pathogen interactions epidemiology
    effective communication strategies), including
    exploration of some high-risk approaches
  • Pilot new disease control strategies tools
    (vaccines diagnostics detection systems
    preventatives producer outreach programs)

50
3 Animal Biosecurity Coordinated Agricultural
Projects
  • Johnes Disease 4.4M/ 2004-2006 (www.jdip.org)
  • PRRS Virus 4.4M/ 2004-2006 (now
    www.porkboard.org/prrs) (soon www.prrs.org)
  • Avian Influenza 5M/ 2005-2007
  • (www.agnr.umd.edu/aicap)

51
Avian Influenza
  • 18 funded states
  • Academia, industry, federal state partners
  • 8 non-funded institutional collaborators

52
AI Objectives
  • Molecular basis for emergence of influenza A in
    chickens turkeys (adaptation from wild
    aquatics co-infections)
  • a) Virus evolution/ surveillance
  • Live Bird Markets (CA,MN,NY)
  • 4 major flyways - migratory non-migratory birds
  • b) Education/ biosecurity programs
  • Diagnostics vaccines

53
AI Coordination
  • DHS National Center for Animal Zoonotic
    Disease Defense
  • Executive Committee UMD OH St. Univ.
    USDA-ARS UC-Davis Auburn Univ.
  • HHS-CDC
  • External Stakeholder Advisory Board
    USDA-APHIS US Poultry Egg Export Council
    United Egg Producers National Turkey
    Federation National Chicken Council
    American Association Avian Pathologists
    Pilgrims Pride Corp. UPenn UMN UT St. U.
  • Scientific Advisory Board USDA-ARS
    NIH-NIAID Perdue Farms Erasmus University-
    Netherlands US Poultry Egg Association

54
THANK YOU!
Everything is OK at the end. If its not OK, its
not the end. -Anonymous
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